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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.251.000
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.592
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.590
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.535
4o0wADNAurora kinase A2.7.11.10.513
5dr9SKEAurora kinase A2.7.11.10.510
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.504
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.504
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.503
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.502
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.497
5dr6SKEAurora kinase A2.7.11.10.496
1pmn984Mitogen-activated protein kinase 102.7.11.240.495
4jqeANPCasein kinase II subunit alpha2.7.11.10.495
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.494
2pvnP63Casein kinase II subunit alpha2.7.11.10.493
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.493
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.493
4jia1K3Tyrosine-protein kinase JAK2/0.492
1xjdSTUProtein kinase C theta type2.7.11.130.491
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.491
2pvhP19Casein kinase II subunit alpha2.7.11.10.491
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.491
1aq1STUCyclin-dependent kinase 22.7.11.220.490
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.490
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.488
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.488
3gxlQIGTGF-beta receptor type-12.7.11.300.488
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.487
4aqc88ATyrosine-protein kinase JAK2/0.485
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.481
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.481
3zewSTUEphrin type-B receptor 42.7.10.10.481
4anmWULCasein kinase II subunit alpha2.7.11.10.481
1wvxBD4Death-associated protein kinase 12.7.11.10.480
3a62STURibosomal protein S6 kinase beta-12.7.11.10.480
3sheI85MAP kinase-activated protein kinase 32.7.11.10.480
4e4m0NHTyrosine-protein kinase JAK2/0.480
4gub0Y4Casein kinase II subunit alpha2.7.11.10.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.479
4hvh19RTyrosine-protein kinase JAK32.7.10.20.477
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.476
4hvg19QTyrosine-protein kinase JAK32.7.10.20.476
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.476
4y93746Tyrosine-protein kinase/0.476
2w1fL0FAurora kinase A2.7.11.10.475
5dpvSKEAurora kinase A2.7.11.10.474
5drdATPAurora kinase A2.7.11.10.474
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
2ckeIQUDeath-associated protein kinase 2/0.473
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.473
5dt3ATPAurora kinase A2.7.11.10.473
5e8ySTUTGF-beta receptor type-22.7.11.300.473
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.472
3gubGUBDeath-associated protein kinase 12.7.11.10.472
4jajXU1Aurora kinase A2.7.11.10.472
4nk92K5Fibroblast growth factor receptor 1/0.472
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.472
1eh4IC1Casein kinase I homolog 12.7.11.10.471
2dwbANPAurora kinase A2.7.11.10.471
2x1nX1NCyclin-dependent kinase 22.7.11.220.471
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.471
3nynSGVG protein-coupled receptor kinase 62.7.11.160.471
4o0sADNAurora kinase A2.7.11.10.471
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.470
3be9P04Casein kinase II subunit alpha2.7.11.10.470
4jbpYPHAurora kinase A2.7.11.10.470
4wsqKSAAP2-associated protein kinase 12.7.11.10.469
1oiyN41Cyclin-dependent kinase 22.7.11.220.468
2p33J07Mitogen-activated protein kinase 102.7.11.240.468
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.468
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.467
4hvi19STyrosine-protein kinase JAK32.7.10.20.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.465
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.465
1yvj4STTyrosine-protein kinase JAK32.7.10.20.464
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.464
3le62BZCyclin-dependent kinase 22.7.11.220.464
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.463
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.463
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3eljGS7Mitogen-activated protein kinase 82.7.11.240.462
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.462
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.462
5av2KMPDeath-associated protein kinase 12.7.11.10.462
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.461
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.461
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.460
2b53D23Cyclin-dependent kinase 22.7.11.220.459
3kvxFMYMitogen-activated protein kinase 102.7.11.240.459
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1h1s4SPCyclin-dependent kinase 22.7.11.220.458
1y91CT9Cyclin-dependent kinase 22.7.11.220.458
2h96893Mitogen-activated protein kinase 82.7.11.240.458
2w05FRTCyclin-dependent kinase 22.7.11.220.458
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.457
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.457
4deeADPAurora kinase A2.7.11.10.457
4hnf16WCasein kinase I isoform delta2.7.11.10.457
4qmpDKISerine/threonine-protein kinase 242.7.11.10.457
5dnrATPAurora kinase A2.7.11.10.457
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.456
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.455
3w2sW2REpidermal growth factor receptor2.7.10.10.455
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
5dt0SKEAurora kinase A2.7.11.10.455
1e9hINRCyclin-dependent kinase 22.7.11.220.454
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
2i40BLZCyclin-dependent kinase 22.7.11.220.454
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.454
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.454
4bcoT6QCyclin-dependent kinase 22.7.11.220.454
4c62XWWTyrosine-protein kinase JAK2/0.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
4jboWPHAurora kinase A2.7.11.10.454
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.454
1g5sI17Cyclin-dependent kinase 22.7.11.220.453
1ppm0P1Penicillopepsin-13.4.23.200.453
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
3l8p0CEAngiopoietin-1 receptor2.7.10.10.453
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1dawANPCasein kinase II subunit alpha2.7.11.10.452
1fvv107Cyclin-dependent kinase 22.7.11.220.452
3ezrEZRCyclin-dependent kinase 22.7.11.220.452
3zh8C58Protein kinase C iota type2.7.11.130.452
4hge15VTyrosine-protein kinase JAK2/0.452
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
1om1IQACasein kinase II subunit alpha2.7.11.10.451
3hllI45Mitogen-activated protein kinase 14/0.451
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.451
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.451
4ux9ANPMitogen-activated protein kinase 82.7.11.240.451
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.450
3lpbNVBTyrosine-protein kinase JAK2/0.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
1bygSTUTyrosine-protein kinase CSK/0.449
2c6tDT5Cyclin-dependent kinase 22.7.11.220.449
2xngA0HAurora kinase A2.7.11.10.449
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4bbfO19Tyrosine-protein kinase JAK2/0.449
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4f081RSTyrosine-protein kinase JAK2/0.449
5dosATPAurora kinase A2.7.11.10.449
1gih1PUCyclin-dependent kinase 22.7.11.220.448
1ke6LS2Cyclin-dependent kinase 22.7.11.220.448
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.448
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3i60E86Mitogen-activated protein kinase 12.7.11.240.448
5dt4ATPAurora kinase A2.7.11.10.448
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.447
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.447
3ttjJBIMitogen-activated protein kinase 102.7.11.240.447
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.447
4deaNHIAurora kinase A2.7.11.10.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.447
4gmy0X5Tyrosine-protein kinase JAK2/0.447
4ix6ADPUncharacterized protein/0.447
4j95ACPFibroblast growth factor receptor 2/0.447
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.446
3rmf20ZCyclin-dependent kinase 22.7.11.220.446
3ttiKBIMitogen-activated protein kinase 102.7.11.240.446
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4bbe3O4Tyrosine-protein kinase JAK2/0.446
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
1pxlCK4Cyclin-dependent kinase 22.7.11.220.445
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.445
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.445
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
2xclANPPhosphoribosylamine--glycine ligase/0.444
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.444
4e6d0NUTyrosine-protein kinase JAK2/0.444
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.444
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.444
5e8xSTUTGF-beta receptor type-12.7.11.300.444
1oecAA2Fibroblast growth factor receptor 2/0.443
2pvmP29Casein kinase II subunit alpha2.7.11.10.443
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.443
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.443
3emg685Tyrosine-protein kinase SYK2.7.10.20.443
3r9dX6BCyclin-dependent kinase 22.7.11.220.443
4j99ACPFibroblast growth factor receptor 2/0.443
4yuqKS1Calmodulin-like domain protein kinase/0.443
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.442
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.442
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3gu7ADPDeath-associated protein kinase 12.7.11.10.442
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.442
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
5dn3ATPAurora kinase A2.7.11.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1pxpCK8Cyclin-dependent kinase 22.7.11.220.441
1py5PY1TGF-beta receptor type-12.7.11.300.441
2excJNKMitogen-activated protein kinase 102.7.11.240.441
2pmoHMDProtein kinase 7/0.441
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3ezvEZVCyclin-dependent kinase 22.7.11.220.441
3hmm855TGF-beta receptor type-12.7.11.300.441
3nxe2NCProtease/0.441
4btjADPTau-tubulin kinase 12.7.11.10.441
4jr7GNPCasein kinase II subunit alpha2.7.11.10.441
1m2rMNYCasein kinase II subunit alpha2.7.11.10.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
2xneASHAurora kinase A2.7.11.10.440
3gu83GUDeath-associated protein kinase 12.7.11.10.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3orkAGSSerine/threonine protein kinase/0.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
4bgh3I6Cyclin-dependent kinase 22.7.11.220.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4f650S9Fibroblast growth factor receptor 1/0.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440