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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bgh3I6Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bgh3I6Cyclin-dependent kinase 22.7.11.221.000
3sw418KCyclin-dependent kinase 22.7.11.220.600
1urwI1PCyclin-dependent kinase 22.7.11.220.592
1pxmCK5Cyclin-dependent kinase 22.7.11.220.588
3ral04ZCyclin-dependent kinase 22.7.11.220.587
4acm7YGCyclin-dependent kinase 22.7.11.220.586
2r3lSCWCyclin-dependent kinase 22.7.11.220.581
3r9dX6BCyclin-dependent kinase 22.7.11.220.579
3rak03ZCyclin-dependent kinase 22.7.11.220.579
2w1hL0FCyclin-dependent kinase 22.7.11.220.577
3rpv26ZCyclin-dependent kinase 22.7.11.220.576
1w0xOLOCyclin-dependent kinase 22.7.11.220.575
3s1h56ZCyclin-dependent kinase 22.7.11.220.575
3rk507ZCyclin-dependent kinase 22.7.11.220.572
4fkr45KCyclin-dependent kinase 22.7.11.220.572
1g5sI17Cyclin-dependent kinase 22.7.11.220.571
1oitHDTCyclin-dependent kinase 22.7.11.220.570
2c6iDT1Cyclin-dependent kinase 22.7.11.220.570
2xmyCDKCyclin-dependent kinase 22.7.11.220.570
3rmf20ZCyclin-dependent kinase 22.7.11.220.570
4fko20KCyclin-dependent kinase 22.7.11.220.570
4fkq42KCyclin-dependent kinase 22.7.11.220.570
4ek816KCyclin-dependent kinase 22.7.11.220.569
3s2pPMUCyclin-dependent kinase 22.7.11.220.568
3qtuX44Cyclin-dependent kinase 22.7.11.220.567
3qtxX43Cyclin-dependent kinase 22.7.11.220.567
3rni21ZCyclin-dependent kinase 22.7.11.220.566
2j9mPY8Cyclin-dependent kinase 22.7.11.220.565
3qxpX64Cyclin-dependent kinase 22.7.11.220.565
2btsU32Cyclin-dependent kinase 22.7.11.220.564
3rjc06ZCyclin-dependent kinase 22.7.11.220.564
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.562
3sw719KCyclin-dependent kinase 22.7.11.220.560
1gih1PUCyclin-dependent kinase 22.7.11.220.558
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.558
3sqq99ZCyclin-dependent kinase 22.7.11.220.558
1pxpCK8Cyclin-dependent kinase 22.7.11.220.555
3lfnA27Cyclin-dependent kinase 22.7.11.220.555
2uznC96Cyclin-dependent kinase 22.7.11.220.554
3unk0BYCyclin-dependent kinase 22.7.11.220.554
2vttLZDCyclin-dependent kinase 22.7.11.220.553
2uzoC62Cyclin-dependent kinase 22.7.11.220.552
3qtzX42Cyclin-dependent kinase 22.7.11.220.552
3qu0X40Cyclin-dependent kinase 22.7.11.220.551
4ek610KCyclin-dependent kinase 22.7.11.220.551
3qxoX65Cyclin-dependent kinase 22.7.11.220.550
4fkt48KCyclin-dependent kinase 22.7.11.220.550
3rpy27ZCyclin-dependent kinase 22.7.11.220.549
1ke7LS3Cyclin-dependent kinase 22.7.11.220.547
1gii1PUCyclin-dependent kinase 22.7.11.220.546
1ke5LS1Cyclin-dependent kinase 22.7.11.220.546
1oguST8Cyclin-dependent kinase 22.7.11.220.546
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.546
2w06FRVCyclin-dependent kinase 22.7.11.220.546
2w17I19Cyclin-dependent kinase 22.7.11.220.545
3r73X87Cyclin-dependent kinase 22.7.11.220.545
1p2a5BNCyclin-dependent kinase 22.7.11.220.544
2b53D23Cyclin-dependent kinase 22.7.11.220.544
2r3iSCFCyclin-dependent kinase 22.7.11.220.543
2r3p3SCCyclin-dependent kinase 22.7.11.220.543
2w05FRTCyclin-dependent kinase 22.7.11.220.543
3rkb12ZCyclin-dependent kinase 22.7.11.220.541
3ezvEZVCyclin-dependent kinase 22.7.11.220.540
3qqhX0ACyclin-dependent kinase 22.7.11.220.539
3r8lZ30Cyclin-dependent kinase 22.7.11.220.539
3s0o50ZCyclin-dependent kinase 22.7.11.220.539
2bheBRYCyclin-dependent kinase 22.7.11.220.538
3qqfX07Cyclin-dependent kinase 22.7.11.220.538
3rk708ZCyclin-dependent kinase 22.7.11.220.538
4fx360KCyclin-dependent kinase 22.7.11.220.538
1pxlCK4Cyclin-dependent kinase 22.7.11.220.536
1ke6LS2Cyclin-dependent kinase 22.7.11.220.534
1pxkCK3Cyclin-dependent kinase 22.7.11.220.533
2r64740Cyclin-dependent kinase 22.7.11.220.533
3ti1B49Cyclin-dependent kinase 22.7.11.220.533
1fvt106Cyclin-dependent kinase 22.7.11.220.532
3rk909ZCyclin-dependent kinase 22.7.11.220.532
3rm719ZCyclin-dependent kinase 22.7.11.220.532
1fvv107Cyclin-dependent kinase 22.7.11.220.531
2r3jSCJCyclin-dependent kinase 22.7.11.220.531
2vv9IM9Cyclin-dependent kinase 22.7.11.220.531
1v1k3FPCyclin-dependent kinase 22.7.11.220.530
3qzgX67Cyclin-dependent kinase 22.7.11.220.530
3wblPDYCyclin-dependent kinase 22.7.11.220.530
1h1s4SPCyclin-dependent kinase 22.7.11.220.529
3lfqA28Cyclin-dependent kinase 22.7.11.220.528
1ykr628Cyclin-dependent kinase 22.7.11.220.527
2c6mDT5Cyclin-dependent kinase 22.7.11.220.527
3qtrX36Cyclin-dependent kinase 22.7.11.220.527
1ke8LS4Cyclin-dependent kinase 22.7.11.220.526
1y91CT9Cyclin-dependent kinase 22.7.11.220.526
2r3kSCQCyclin-dependent kinase 22.7.11.220.525
4fkw62KCyclin-dependent kinase 22.7.11.220.525
1pxoCK7Cyclin-dependent kinase 22.7.11.220.524
3ddpRC8Cyclin-dependent kinase 22.7.11.220.524
3qqkX02Cyclin-dependent kinase 22.7.11.220.524
4fkv61KCyclin-dependent kinase 22.7.11.220.524
2iw84SPCyclin-dependent kinase 22.7.11.220.523
1oirHDYCyclin-dependent kinase 22.7.11.220.521
2r3r6SCCyclin-dependent kinase 22.7.11.220.521
3py0SU9Cyclin-dependent kinase 22.7.11.220.521
2btrU73Cyclin-dependent kinase 22.7.11.220.520
2vu3LZECyclin-dependent kinase 22.7.11.220.520
3iggEFQCyclin-dependent kinase 22.7.11.220.520
3r7yZ04Cyclin-dependent kinase 22.7.11.220.520
4fkpLS5Cyclin-dependent kinase 22.7.11.220.520
3qzfX66Cyclin-dependent kinase 22.7.11.220.519
3r9hZ67Cyclin-dependent kinase 22.7.11.220.519
1pkdUCNCyclin-dependent kinase 22.7.11.220.517
2a0cCK9Cyclin-dependent kinase 22.7.11.220.517
2fvdLIACyclin-dependent kinase 22.7.11.220.517
1vyzN5BCyclin-dependent kinase 22.7.11.220.516
4fks46KCyclin-dependent kinase 22.7.11.220.516
1gij2PUCyclin-dependent kinase 22.7.11.220.515
1h1r6CPCyclin-dependent kinase 22.7.11.220.515
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.514
3pj8404Cyclin-dependent kinase 22.7.11.220.513
3rpo24ZCyclin-dependent kinase 22.7.11.220.513
3unj0BXCyclin-dependent kinase 22.7.11.220.513
4eok4SPCyclin-dependent kinase 22.7.11.220.513
3uli1N3Cyclin-dependent kinase 22.7.11.220.511
1oi9N20Cyclin-dependent kinase 22.7.11.220.510
3ezrEZRCyclin-dependent kinase 22.7.11.220.510
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.510
1w8cN69Cyclin-dependent kinase 22.7.11.220.509
3qwjX6ACyclin-dependent kinase 22.7.11.220.509
3r71X86Cyclin-dependent kinase 22.7.11.220.508
1ckpPVBCyclin-dependent kinase 22.7.11.220.507
4qmpDKISerine/threonine-protein kinase 242.7.11.10.506
2b52D42Cyclin-dependent kinase 22.7.11.220.505
3r7iX9ICyclin-dependent kinase 22.7.11.220.505
3r8pZ46Cyclin-dependent kinase 22.7.11.220.505
1pyePM1Cyclin-dependent kinase 22.7.11.220.504
3qzhX69Cyclin-dependent kinase 22.7.11.220.504
4ez30S0Cyclin-dependent kinase 22.7.11.220.504
1h0w207Cyclin-dependent kinase 22.7.11.220.503
3roy22ZCyclin-dependent kinase 22.7.11.220.503
2duv371Cyclin-dependent kinase 22.7.11.220.502
2i40BLZCyclin-dependent kinase 22.7.11.220.502
4erwSTUCyclin-dependent kinase 22.7.11.220.502
2bhhRYUCyclin-dependent kinase 22.7.11.220.501
2c5nCK8Cyclin-dependent kinase 22.7.11.220.501
3lfsA07Cyclin-dependent kinase 22.7.11.220.501
3ig7EFPCyclin-dependent kinase 22.7.11.220.500
3qqlX03Cyclin-dependent kinase 22.7.11.220.500
3r8vZ62Cyclin-dependent kinase 22.7.11.220.500
3raiX85Cyclin-dependent kinase 22.7.11.220.500
3rzb02ZCyclin-dependent kinase 22.7.11.220.500
4bcmT7ZCyclin-dependent kinase 22.7.11.220.500
4lyn1YGCyclin-dependent kinase 22.7.11.220.500
1e9hINRCyclin-dependent kinase 22.7.11.220.499
3qruX19Cyclin-dependent kinase 22.7.11.220.499
3qwkX62Cyclin-dependent kinase 22.7.11.220.499
2c6o4SPCyclin-dependent kinase 22.7.11.220.498
2c6tDT5Cyclin-dependent kinase 22.7.11.220.497
3dogNNNCyclin-dependent kinase 22.7.11.220.497
3r7uX96Cyclin-dependent kinase 22.7.11.220.497
1aq1STUCyclin-dependent kinase 22.7.11.220.496
3r6xX84Cyclin-dependent kinase 22.7.11.220.496
1di8DTQCyclin-dependent kinase 22.7.11.220.495
1unlRRCCyclin-dependent-like kinase 52.7.11.10.495
1ke9LS5Cyclin-dependent kinase 22.7.11.220.494
3rm618ZCyclin-dependent kinase 22.7.11.220.494
2b55D31Cyclin-dependent kinase 22.7.11.220.493
2xnbY8LCyclin-dependent kinase 22.7.11.220.493
3qtqX35Cyclin-dependent kinase 22.7.11.220.493
3ddqRRCCyclin-dependent kinase 22.7.11.220.492
3r9nZ68Cyclin-dependent kinase 22.7.11.220.492
2x1nX1NCyclin-dependent kinase 22.7.11.220.491
3r1sX73Cyclin-dependent kinase 22.7.11.220.491
1oiyN41Cyclin-dependent kinase 22.7.11.220.490
3r1yX76Cyclin-dependent kinase 22.7.11.220.490
3r8uZ31Cyclin-dependent kinase 22.7.11.220.490
4ivd15TTyrosine-protein kinase JAK1/0.490
4kd11QKCyclin-dependent kinase 22.7.11.220.490
2r3fSC8Cyclin-dependent kinase 22.7.11.220.489
1dm2HMDCyclin-dependent kinase 22.7.11.220.488
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.488
4fkg4CKCyclin-dependent kinase 22.7.11.220.488
2c6lDT4Cyclin-dependent kinase 22.7.11.220.487
2wxvWXVCyclin-dependent kinase 22.7.11.220.487
3qx2X63Cyclin-dependent kinase 22.7.11.220.487
4eor4SPCyclin-dependent kinase 22.7.11.220.486
3r1qX75Cyclin-dependent kinase 22.7.11.220.485
3r83Z14Cyclin-dependent kinase 22.7.11.220.485
3tnwF18Cyclin-dependent kinase 22.7.11.220.485
2r3o2SCCyclin-dependent kinase 22.7.11.220.484
3r9oZ71Cyclin-dependent kinase 22.7.11.220.484
4bcpT3CCyclin-dependent kinase 22.7.11.220.484
2uzbC75Cyclin-dependent kinase 22.7.11.220.483
3rahO1ZCyclin-dependent kinase 22.7.11.220.483
3s00Z60Cyclin-dependent kinase 22.7.11.220.483
4bcnT9NCyclin-dependent kinase 22.7.11.220.483
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.483
2uzlC94Cyclin-dependent kinase 22.7.11.220.481
3r28XA0Cyclin-dependent kinase 22.7.11.220.481
3sheI85MAP kinase-activated protein kinase 32.7.11.10.481
1y8yCT7Cyclin-dependent kinase 22.7.11.220.480
2c6kDT2Cyclin-dependent kinase 22.7.11.220.480
3r7vZ02Cyclin-dependent kinase 22.7.11.220.480
3r8zZ63Cyclin-dependent kinase 22.7.11.220.480
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.479
2r3mSCXCyclin-dependent kinase 22.7.11.220.479
2r3q5SCCyclin-dependent kinase 22.7.11.220.479
2pvnP63Casein kinase II subunit alpha2.7.11.10.476
2r3gSC9Cyclin-dependent kinase 22.7.11.220.476
3ql8X01Cyclin-dependent kinase 22.7.11.220.476
4ivb1J5Tyrosine-protein kinase JAK1/0.476
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.476
1e1xNW1Cyclin-dependent kinase 22.7.11.220.475
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.475
4fki09KCyclin-dependent kinase 22.7.11.220.474
1vyw292Cyclin-dependent kinase 22.7.11.220.473
3le62BZCyclin-dependent kinase 22.7.11.220.473
4fkj11KCyclin-dependent kinase 22.7.11.220.473
4ivc1J6Tyrosine-protein kinase JAK1/0.473
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.472
1h1pCMGCyclin-dependent kinase 22.7.11.220.471
2uzdC85Cyclin-dependent kinase 22.7.11.220.471
3pxyJWSCyclin-dependent kinase 22.7.11.220.471
3fz1B98Cyclin-dependent kinase 22.7.11.220.470
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
2iw94SPCyclin-dependent kinase 22.7.11.220.469
3qtsX46Cyclin-dependent kinase 22.7.11.220.469
3qtwX3ACyclin-dependent kinase 22.7.11.220.469
4hge15VTyrosine-protein kinase JAK2/0.469
5dr6SKEAurora kinase A2.7.11.10.469
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.467
4i5cC5ITyrosine-protein kinase JAK1/0.467
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.467
5dr9SKEAurora kinase A2.7.11.10.467
1r78FMDCyclin-dependent kinase 22.7.11.220.466
2a4lRRCCyclin-dependent kinase 22.7.11.220.466
2vtsLZCCyclin-dependent kinase 22.7.11.220.466
3qrtX14Cyclin-dependent kinase 22.7.11.220.466
3qziX72Cyclin-dependent kinase 22.7.11.220.466
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.466
3my5RFZCyclin-dependent kinase 22.7.11.220.465
4aqc88ATyrosine-protein kinase JAK2/0.465
1eh4IC1Casein kinase I homolog 12.7.11.10.464
2b54D05Cyclin-dependent kinase 22.7.11.220.464
2vthLZ2Cyclin-dependent kinase 22.7.11.220.464
2wihP48Cyclin-dependent kinase 22.7.11.220.464
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.464
1xjdSTUProtein kinase C theta type2.7.11.130.463
2eufLQQCyclin-dependent kinase 62.7.11.220.463
2uzeC95Cyclin-dependent kinase 22.7.11.220.463
3nynSGVG protein-coupled receptor kinase 62.7.11.160.463
4dgnLU2Casein kinase II subunit alpha2.7.11.10.463
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.463
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.462
1oiuN76Cyclin-dependent kinase 22.7.11.220.461
2c5yMTWCyclin-dependent kinase 22.7.11.220.461
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.460
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
5dt0SKEAurora kinase A2.7.11.10.460
2vtqLZACyclin-dependent kinase 22.7.11.220.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.459
2cchATPCyclin-dependent kinase 22.7.11.220.458
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.458
4eol1ROCyclin-dependent kinase 22.7.11.220.458
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.458
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.458
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.457
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
3qx4X4BCyclin-dependent kinase 22.7.11.220.455
4e6d0NUTyrosine-protein kinase JAK2/0.455
2pvhP19Casein kinase II subunit alpha2.7.11.10.454
2wpa889Cyclin-dependent kinase 22.7.11.220.454
3r7eX88Cyclin-dependent kinase 22.7.11.220.454
4bcoT6QCyclin-dependent kinase 22.7.11.220.454
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.454
2b7aIZATyrosine-protein kinase JAK2/0.453
3rpr25ZCyclin-dependent kinase 22.7.11.220.453
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4eon1ROCyclin-dependent kinase 22.7.11.220.453
4ez50RSCyclin-dependent kinase 62.7.11.220.453
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
3ggfGVDSerine/threonine-protein kinase 26/0.452
4cfnJYMCyclin-dependent kinase 22.7.11.220.452
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
4ei40Q2Tyrosine-protein kinase JAK1/0.450
1meuDMPGag-Pol polyprotein3.4.23.160.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
1xl2189Gag-Pol polyprotein3.4.23.160.449
2c69CT8Cyclin-dependent kinase 22.7.11.220.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.449
3gubGUBDeath-associated protein kinase 12.7.11.10.449
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.449
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
1oiqHDUCyclin-dependent kinase 22.7.11.220.447
1wvxBD4Death-associated protein kinase 12.7.11.10.447
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.446
3a62STURibosomal protein S6 kinase beta-12.7.11.10.446
3tiz3TICyclin-dependent kinase 22.7.11.220.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1om1IQACasein kinase II subunit alpha2.7.11.10.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
1finATPCyclin-dependent kinase 22.7.11.220.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4aua4AUCyclin-dependent kinase 62.7.11.220.443
4btjATPTau-tubulin kinase 12.7.11.10.443
1v0pPVBCell division control protein 2 homolog2.7.11.220.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.442
3zep1NXTyrosine-protein kinase JAK32.7.10.20.442
4c61LMMTyrosine-protein kinase JAK2/0.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.441
1xl5190Gag-Pol polyprotein3.4.23.160.441
2c4g514Cyclin-dependent kinase 22.7.11.220.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2wipP49Cyclin-dependent kinase 22.7.11.220.441
3eb0DRKUncharacterized protein/0.441
3lq5SLQCyclin-dependent kinase 92.7.11.220.441
4eop1ROCyclin-dependent kinase 22.7.11.220.441
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440