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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bfq083Soluble acetylcholine receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bfq083Soluble acetylcholine receptor/1.000
2wzySQXSoluble acetylcholine receptor/0.561
2xytTC9Soluble acetylcholine receptor/0.493
4bfsZVSPantothenate kinase2.7.1.330.473
4bfxZVXPantothenate kinase2.7.1.330.470
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.468
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.463
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.462
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.461
1rpwDIDHTH-type transcriptional regulator QacR/0.460
4rvfTYDD-mycarose 3-C-methyltransferase/0.459
4e2yJHZMethyltransferase/0.458
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.457
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.455
4dbs0HVAldo-keto reductase family 1 member C3/0.454
2r8pT6FTransketolase 1/0.453
2geuCOKPantothenate kinase2.7.1.330.452
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.451
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.449
2gv8NDPThiol-specific monooxygenase1.14.130.448
2ha6SCKAcetylcholinesterase3.1.1.70.448
2lfoGCHFatty acid-binding protein, liver/0.447
3mauEXTPutative sphingosine-1-phosphate lyase/0.446
3v0p4GWHisto-blood group ABO system transferase/0.446
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.446
1eveE20Acetylcholinesterase3.1.1.70.445
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.443
2po3T4K4-dehydrase/0.442
4frkDWDBeta-secretase 13.4.23.460.442
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1q84TZ4Acetylcholinesterase3.1.1.70.440
2gevCOKPantothenate kinase2.7.1.330.440
3v0o4GWHisto-blood group ABO system transferase/0.440
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.440