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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bc6XZNSerine/threonine-protein kinase 102.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bc6XZNSerine/threonine-protein kinase 102.7.11.11.000
2j7t274Serine/threonine-protein kinase 102.7.11.10.530
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.511
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.508
4nka2K7Fibroblast growth factor receptor 1/0.507
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.503
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.502
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.501
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.493
4f640S8Fibroblast growth factor receptor 1/0.492
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
3uvqFS8Mitogen-activated protein kinase 14/0.489
3zewSTUEphrin type-B receptor 42.7.10.10.489
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.484
4eym0RXMitogen-activated protein kinase 132.7.11.240.480
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.478
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.478
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.478
3w2sW2REpidermal growth factor receptor2.7.10.10.476
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.474
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.471
4nks2M2Fibroblast growth factor receptor 1/0.471
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.469
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
2zybKSLTyrosine-protein kinase Lck2.7.10.20.467
3w2o03PEpidermal growth factor receptor2.7.10.10.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.465
3js2VM1Fibroblast growth factor receptor 1/0.465
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.465
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.464
2itzIREEpidermal growth factor receptor2.7.10.10.463
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.463
3w2rW2REpidermal growth factor receptor2.7.10.10.463
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
2fgiPD1Fibroblast growth factor receptor 1/0.460
2c6eHPMAurora kinase A2.7.11.10.459
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.459
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
1finATPCyclin-dependent kinase 22.7.11.220.455
1m17AQ4Epidermal growth factor receptor2.7.10.10.453
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2hk51BMTyrosine-protein kinase HCK2.7.10.20.451
2of4979Tyrosine-protein kinase Lck2.7.10.20.450
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4xhgADPUncharacterized protein/0.450
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.449
1w84L12Mitogen-activated protein kinase 14/0.449
4jrvKJVEpidermal growth factor receptor2.7.10.10.449
1k6pXN3Gag-Pol polyprotein3.4.23.160.448
2of2547Tyrosine-protein kinase Lck2.7.10.20.448
4nk92K5Fibroblast growth factor receptor 1/0.448
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2q0bACPFibroblast growth factor receptor 2/0.447
4j99ACPFibroblast growth factor receptor 2/0.447
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.447
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.447
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
1ouy094Mitogen-activated protein kinase 14/0.446
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.446
1bygSTUTyrosine-protein kinase CSK/0.445
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.445
2i0ePDSProtein kinase C beta type2.7.11.130.445
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.445
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.445
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2itqITQEpidermal growth factor receptor2.7.10.10.444
2xyuQ9GEphrin type-A receptor 42.7.10.10.444
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.444
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3w33W19Epidermal growth factor receptor2.7.10.10.444
4jboWPHAurora kinase A2.7.11.10.444
2py3ACPFibroblast growth factor receptor 2/0.443
4j98ACPFibroblast growth factor receptor 2/0.443
5dr9SKEAurora kinase A2.7.11.10.443
2vwx7X4Ephrin type-B receptor 42.7.10.10.442
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.442
3ac2KSETyrosine-protein kinase Lck2.7.10.20.442
4gk4L90Ephrin type-A receptor 32.7.10.10.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
2fvdLIACyclin-dependent kinase 22.7.11.220.441
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440