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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4b8zNAPGDP-L-fucose synthase1.1.1.271

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4b8zNAPGDP-L-fucose synthase1.1.1.2711.000
4b8wNAPGDP-L-fucose synthase1.1.1.2710.602
4e5yNDPGDP-L-fucose synthase1.1.1.2710.536
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.502
4j7xNAPSepiapterin reductase1.1.1.1530.493
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.489
4j7uNAPSepiapterin reductase1.1.1.1530.487
3a4vNADNDP-sugar epimerase/0.475
1rkxNADCDP-D-glucose-4,6-dehydratase/0.463
1snyNAPLD36273p/0.463
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.461
4hwkNAPSepiapterin reductase1.1.1.1530.461
1wntNAPL-xylulose reductase1.1.1.100.459
1pr9NAPL-xylulose reductase1.1.1.100.458
3a1nNADNDP-sugar epimerase/0.456
3gy0NAPNAD(P)-dependent oxidoreductase/0.456
1oaaNAPSepiapterin reductase1.1.1.1530.454
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
2p5uNADUDP-glucose 4-epimerase/0.450
1xg5NAPDehydrogenase/reductase SDR family member 11/0.449
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.447
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.444
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2yutNAPPutative short-chain oxidoreductase/0.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
3sjuNDPKeto reductase/0.441
3toxNAPPutative oxidoreductase/0.441
3w8eNAD3-hydroxybutyrate dehydrogenase/0.440
4bmvNAPShort-chain dehydrogenase/0.440
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440