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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4b79NADProbable short-chain dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4b79NADProbable short-chain dehydrogenase/1.000
3w8eNAD3-hydroxybutyrate dehydrogenase/0.570
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.553
1g6kNADGlucose 1-dehydrogenase1.1.1.470.550
3w8dNAD3-hydroxybutyrate dehydrogenase/0.545
3ai2NDPNADPH-sorbose reductase/0.544
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.543
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.543
3w8fNAD3-hydroxybutyrate dehydrogenase/0.543
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.543
1xkqNDPUncharacterized protein/0.541
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.538
3vdqNAD3-hydroxybutyrate dehydrogenase/0.537
4qecNAPElxO/0.528
3ai3NDPNADPH-sorbose reductase/0.525
3toxNAPPutative oxidoreductase/0.522
4j7xNAPSepiapterin reductase1.1.1.1530.517
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.515
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.512
4nbwNADShort-chain dehydrogenase/reductase SDR/0.512
4j7uNAPSepiapterin reductase1.1.1.1530.509
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.507
5jlaNADPutative short-chain dehydrogenase/reductase/0.505
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.502
1gcoNADGlucose 1-dehydrogenase1.1.1.470.500
1xg5NAPDehydrogenase/reductase SDR family member 11/0.499
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.498
3lqfNADGalactitol dehydrogenase/0.497
4esoNAPPutative oxidoreductase/0.496
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.495
1geeNADGlucose 1-dehydrogenase1.1.1.470.494
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.494
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.491
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.489
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.489
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.488
1oaaNAPSepiapterin reductase1.1.1.1530.486
1w4zNAPPutative ketoacyl reductase1.3.10.486
2yutNAPPutative short-chain oxidoreductase/0.486
1n5dNDPCarbonyl reductase [NADPH] 1/0.485
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.485
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.484
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.484
4hwkNAPSepiapterin reductase1.1.1.1530.484
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.484
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.483
1zemNADXylitol dehydrogenase/0.483
3p19NDPPutative blue fluorescent protein/0.481
3l77NJPShort-chain alcohol dehydrogenase/0.480
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.479
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.479
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.478
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.477
1rwbNADGlucose 1-dehydrogenase1.1.1.470.476
4bmvNAPShort-chain dehydrogenase/0.476
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.475
4yagNAIC alpha-dehydrogenase/0.474
2wdzNADGalactitol dehydrogenase/0.473
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.472
1x7hNDPPutative ketoacyl reductase1.3.10.471
3gy0NAPNAD(P)-dependent oxidoreductase/0.471
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.470
2jahNDPClavaldehyde dehydrogenase/0.470
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.470
3wdsNADNADH-dependent quinuclidinone reductase/0.470
2dteNAIGlucose 1-dehydrogenase related protein/0.469
4gh5NADShort-chain dehydrogenase/reductase SDR/0.469
4yaiNAIC alpha-dehydrogenase/0.469
4e5yNDPGDP-L-fucose synthase1.1.1.2710.468
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.467
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
3ak4NADNADH-dependent quinuclidinone reductase/0.465
3f1kNAPUncharacterized oxidoreductase YciK10.464
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.463
1iy8NADLevodione reductase/0.462
1pr9NAPL-xylulose reductase1.1.1.100.461
3d3wNAPL-xylulose reductase1.1.1.100.461
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.461
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.461
1ipeNDPTropinone reductase 21.1.1.2360.460
3uceNDPDehydrogenase/0.460
4qedNAPElxO/0.460
5lc1NADL-threonine 3-dehydrogenase/0.460
1x7gNAPPutative ketoacyl reductase1.3.10.459
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.459
1ae1NAPTropinone reductase 1/0.458
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.457
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.457
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.456
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.456
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.455
3qrwNDPPutative ketoacyl reductase1.3.10.455
3sjuNDPKeto reductase/0.455
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
3bmoNAPPteridine reductase/0.453
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.453
3uxyNADShort-chain dehydrogenase/reductase SDR/0.452
2wsbNADGalactitol dehydrogenase/0.451
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.450
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.450
1wntNAPL-xylulose reductase1.1.1.100.449
2c20NADUDP-glucose 4-epimerase/0.449
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.449
3s55NADPutative short-chain dehydrogenase/reductase/0.449
4b8wNAPGDP-L-fucose synthase1.1.1.2710.449
5idwNAPShort-chain dehydrogenase/reductase SDR/0.449
1g1aNADdTDP-glucose 4,6-dehydratase/0.448
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.448
5jy1NADPutative short-chain dehydrogenase/reductase/0.448
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.447
2a92NAIL-lactate dehydrogenase/0.447
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.447
4dc1NDPPutative ketoacyl reductase1.3.10.447
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.446
2bd0NAPSepiapterin reductase/0.446
2p5uNADUDP-glucose 4-epimerase/0.446
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3r3sNADPutative oxidoreductase/0.445
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.445
4fn4NADShort chain dehydrogenase/0.445
3sx2NADUncharacterized protein/0.444
5dbgNADIridoid synthase1.3.1.990.443
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.442
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.440
3a4vNADNDP-sugar epimerase/0.440
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.440