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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4awiAQ2Mitogen-activated protein kinase 82.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4awiAQ2Mitogen-activated protein kinase 82.7.11.241.000
3kvxFMYMitogen-activated protein kinase 102.7.11.240.578
1pmn984Mitogen-activated protein kinase 102.7.11.240.537
4ux9ANPMitogen-activated protein kinase 82.7.11.240.523
1jnkANPMitogen-activated protein kinase 102.7.11.240.516
2xrwANPMitogen-activated protein kinase 82.7.11.240.513
3cgfJNFMitogen-activated protein kinase 102.7.11.240.508
3i60E86Mitogen-activated protein kinase 12.7.11.240.497
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.493
2p33J07Mitogen-activated protein kinase 102.7.11.240.489
2xs0ANPMitogen-activated protein kinase 82.7.11.240.484
3dfcANPDeath-associated protein kinase 12.7.11.10.483
4qnyANPMitogen activated protein kinase, putative/0.480
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.479
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.478
1dawANPCasein kinase II subunit alpha2.7.11.10.474
5ap7SVEDual specificity protein kinase TTK2.7.12.10.474
1dayGNPCasein kinase II subunit alpha2.7.11.10.473
4btjADPTau-tubulin kinase 12.7.11.10.472
4lfiGNPCasein kinase II subunit alpha2.7.11.10.470
4anmWULCasein kinase II subunit alpha2.7.11.10.469
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
4g1wG1WMitogen-activated protein kinase 82.7.11.240.469
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.468
4hyu1BKMitogen-activated protein kinase 82.7.11.240.467
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
3orpAGSSerine/threonine protein kinase/0.463
4j95ACPFibroblast growth factor receptor 2/0.463
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.462
3gu7ADPDeath-associated protein kinase 12.7.11.10.462
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.461
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.460
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.460
5dnrATPAurora kinase A2.7.11.10.460
1i44ACPInsulin receptor2.7.10.10.458
4jqeANPCasein kinase II subunit alpha2.7.11.10.457
4deeADPAurora kinase A2.7.11.10.456
4e730NRMitogen-activated protein kinase 82.7.11.240.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.455
3ormAGSSerine/threonine protein kinase/0.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.452
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.451
5cnoANPEpidermal growth factor receptor2.7.10.10.451
2excJNKMitogen-activated protein kinase 102.7.11.240.449
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.449
4jia1K3Tyrosine-protein kinase JAK2/0.448
2j0lANPFocal adhesion kinase 12.7.10.20.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.446
3ttjJBIMitogen-activated protein kinase 102.7.11.240.446
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.446
2yaaATPDeath-associated protein kinase 2/0.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
3oroAGSSerine/threonine protein kinase/0.442
4ic7ANPMitogen-activated protein kinase 72.7.11.240.442
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.441
2henADPEphrin type-B receptor 22.7.10.10.441
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440