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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aseAV9Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aseAV9Vascular endothelial growth factor receptor 22.7.10.11.000
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.653
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.652
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.611
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.611
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.597
3hng8STVascular endothelial growth factor receptor 12.7.10.10.591
3efl706Vascular endothelial growth factor receptor 22.7.10.10.585
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.584
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.582
2xir00JVascular endothelial growth factor receptor 22.7.10.10.577
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.574
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.571
2hyySTITyrosine-protein kinase ABL12.7.10.20.565
4eyjN61Mitogen-activated protein kinase 132.7.11.240.561
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.561
4o2z046Mitogen-activated protein kinase/0.561
1iepSTITyrosine-protein kinase ABL12.7.10.20.547
3ce31FNHepatocyte growth factor receptor2.7.10.10.544
3eta351Insulin receptor2.7.10.10.541
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.540
3ctj320Hepatocyte growth factor receptor2.7.10.10.539
2og81N8Tyrosine-protein kinase Lck2.7.10.20.532
3hv5R24Mitogen-activated protein kinase 14/0.524
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.517
4aa0AA0Mitogen-activated protein kinase 14/0.513
4qrc0LIFibroblast growth factor receptor 42.7.10.10.511
4kaoKAOFocal adhesion kinase 12.7.10.20.503
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.496
4eevL1XHepatocyte growth factor receptor2.7.10.10.494
3tubFPUTyrosine-protein kinase SYK2.7.10.20.489
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.485
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.483
3kq7KQ7Mitogen-activated protein kinase 14/0.476
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.470
3lfbZ87Mitogen-activated protein kinase 14/0.462
2y00Y01Beta-1 adrenergic receptor/0.460
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3ds6A17Mitogen-activated protein kinase 14/0.454
3gcsBAXMitogen-activated protein kinase 14/0.454
3iw8HIZMitogen-activated protein kinase 14/0.454
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.452
2y01Y01Beta-1 adrenergic receptor/0.449
3ol5SAWCamphor 5-monooxygenase1.14.15.10.447
3p6mDSOCamphor 5-monooxygenase1.14.15.10.447
3wmxNADNAD dependent epimerase/dehydratase/0.447
3dl9V2HVitamin D 25-hydroxylase/0.446
4l9q9TPSerum albumin/0.441
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440