sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4anb | YQY | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4anb | YQY | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 1.000 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.664 | |
| 4an2 | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.613 | |
| 4lmn | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.594 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.589 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.589 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.584 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.584 | |
| 3v01 | 3V0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.582 | |
| 2p55 | MRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.568 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.566 | |
| 1s9j | BBM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.565 | |
| 3vvh | 4BM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.565 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.562 | |
| 3dy7 | 1CX | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.559 | |
| 3orn | 3OR | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.555 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.528 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.475 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.469 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.467 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.466 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.465 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.465 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.464 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.462 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.462 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.456 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.455 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.453 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.452 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.450 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.450 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.447 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4aa0 | AA0 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.444 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.444 | |
| 2h12 | CMX | Citrate synthase | / | 0.443 | |
| 2idw | 017 | Protease | / | 0.443 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.443 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.442 | |
| 3zuy | TCH | Transporter | / | 0.442 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.442 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3lin | E13 | Protease | / | 0.441 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4dce | 0JF | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.440 | |
| 2jd1 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 3efl | 706 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.440 |