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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4alhA9PBromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4alhA9PBromodomain-containing protein 2/1.000
2ydwWSHBromodomain-containing protein 2/0.663
4uyf73BBromodomain-containing protein 2/0.645
2yekEAMBromodomain-containing protein 2/0.613
4c67L5SBromodomain-containing protein 4/0.577
4a9mP9MBromodomain-containing protein 2/0.568
4o701QKBromodomain-containing protein 4/0.560
4a9hTVPBromodomain-containing protein 2/0.558
4aknS5BBromodomain-containing protein 2/0.557
4a9e3PFBromodomain-containing protein 2/0.555
4o761M3Bromodomain-containing protein 4/0.555
4a9iP9IBromodomain-containing protein 2/0.553
4a9oA9OBromodomain-containing protein 2/0.552
4flpJQ1Bromodomain testis-specific protein/0.537
4hxs1A3Bromodomain-containing protein 4/0.537
4j0s1H3Bromodomain-containing protein 4/0.523
4uyg73BBromodomain-containing protein 2/0.518
2yelWSHBromodomain-containing protein 4/0.516
4o71CPBBromodomain-containing protein 4/0.516
4a9nA9NBromodomain-containing protein 2/0.511
4bjx73BBromodomain-containing protein 4/0.509
4bw1S5BBromodomain-containing protein 4/0.509
4lrg1XBBromodomain-containing protein 4/0.508
4a9lP9LBromodomain-containing protein 4/0.497
4lr61XABromodomain-containing protein 4/0.496
4bw39BMBromodomain-containing protein 4/0.495
4men25KBromodomain-containing protein 4/0.493
4mr61K0Bromodomain-containing protein 2/0.493
4py6R78Bromodomain protein, putative/0.493
3aqaBYHBromodomain-containing protein 2/0.492
4c66H4CBromodomain-containing protein 4/0.490
4mr41K0Bromodomain-containing protein 4/0.485
4j0r1H2Bromodomain-containing protein 4/0.482
4j1p1K0Bromodomain-containing protein 2/0.480
4o78SAVBromodomain-containing protein 4/0.480
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.479
4bw2UTHBromodomain-containing protein 4/0.479
4nqmY1ZBromodomain-containing protein 4/0.479
4ogiR78Bromodomain-containing protein 4/0.477
4j3i1K0Bromodomain-containing protein 4/0.476
3zyu1GHBromodomain-containing protein 4/0.473
5bt52LOBromodomain-containing protein 2/0.472
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.471
4hxn1A7Bromodomain-containing protein 4/0.470
4lyw21QBromodomain-containing protein 4/0.470
4mep24YBromodomain-containing protein 4/0.468
1ia3TQ5Dihydrofolate reductase1.5.1.30.467
4e960NSBromodomain-containing protein 4/0.467
4qzsJQ1Bromodomain-containing protein 4/0.467
1rx8FOLDihydrofolate reductase1.5.1.30.466
1thnADPAnti-sigma F factor/0.465
2w9hTOPDihydrofolate reductase1.5.1.30.465
1uy7PU4Heat shock protein HSP 90-alpha/0.464
4meq25OBromodomain-containing protein 4/0.464
5bt42LOBromodomain-containing protein 4/0.464
4hbw14ZBromodomain-containing protein 4/0.463
4ryvZEAProtein LlR18A/0.462
2znq401Peroxisome proliferator-activated receptor delta/0.461
2cig1DGDihydrofolate reductase1.5.1.30.460
4hby13FBromodomain-containing protein 4/0.460
5hs1VORLanosterol 14-alpha demethylase/0.459
3tk3CPZCytochrome P450 2B41.14.14.10.458
4meo25VBromodomain-containing protein 4/0.458
3mdmFJZCholesterol 24-hydroxylase/0.457
3mdvCL6Cholesterol 24-hydroxylase/0.457
1uzwCDHIsopenicillin N synthase1.21.3.10.456
1r2jFADFkbI/0.455
3zkyWT4Isopenicillin N synthase1.21.3.10.455
1fmlRTLRetinol dehydratase/0.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
3vspEK8Peroxisome proliferator-activated receptor gamma/0.454
4elb34RDihydrofolate reductase/0.454
4f3i0S6Bromodomain-containing protein 4/0.454
5ii2LU2Protein polybromo-1/0.454
1ia4TQ6Dihydrofolate reductase1.5.1.30.453
1x8lOXRRetinol dehydratase/0.453
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.453
3ddw055Glycogen phosphorylase, liver form2.4.1.10.453
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4o74R78Bromodomain-containing protein 4/0.453
1cjkFOKAdenylate cyclase type 2/0.452
1cjkFOKAdenylate cyclase type 5/0.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.452
4hxr1A4Bromodomain-containing protein 4/0.452
1yw2PGJMitogen-activated protein kinase 14/0.451
4nr52LLCREB-binding protein/0.451
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1jpaANPEphrin type-B receptor 22.7.10.10.450
4h9614QDihydrofolate reductase1.5.1.30.450
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4gpj0Q1Bromodomain-containing protein 4/0.449
1culFOKAdenylate cyclase type 2/0.448
1culFOKAdenylate cyclase type 5/0.448
4nyv15ECREB-binding protein/0.448
2hcdBIVVitamin D3 receptor A/0.447
4ele31IDihydrofolate reductase/0.447
4nmbFADBifunctional protein PutA/0.447
1kzjCB3Thymidylate synthase/0.446
1vrwNAIEnoyl-ACP reductase/0.446
1xddAAYIntegrin alpha-L/0.446
2ovhAS0Progesterone receptor/0.446
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
3oafOAGDihydrofolate reductase1.5.1.30.446
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4q73FADBifunctional protein PutA/0.446
1dr3HBIDihydrofolate reductase1.5.1.30.445
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.445
3drcMTXDihydrofolate reductase1.5.1.30.445
3pm9FADPutative oxidoreductase/0.445
3zuxTCHTransporter/0.445
4gk2L66Ephrin type-A receptor 32.7.10.10.445
4hxo1A6Bromodomain-containing protein 4/0.445
1ppjANYCytochrome b/0.444
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.444
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
3c1y2BADNA integrity scanning protein DisA/0.444
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4cfl8DQBromodomain-containing protein 4/0.444
4enhFVXCholesterol 24-hydroxylase/0.444
1dhiMTXDihydrofolate reductase1.5.1.30.443
1uyhPU0Heat shock protein HSP 90-alpha/0.443
3a4pDFQHepatocyte growth factor receptor2.7.10.10.443
3fwgCAMCamphor 5-monooxygenase1.14.15.10.443
3och2MXDihydrofolate reductase1.5.1.30.443
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.443
4mr51K0Bromodomain-containing protein 2/0.443
3gggNADPrephenate dehydrogenase/0.442
3p3zP3ZPutative cytochrome P450/0.442
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.442
3zuyTCHTransporter/0.442
1qiqACCIsopenicillin N synthase1.21.3.10.441
1uy8PU5Heat shock protein HSP 90-alpha/0.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
3a1l2CCCytochrome P450/0.441
3ctj320Hepatocyte growth factor receptor2.7.10.10.441
3dj4UD1Bifunctional protein GlmU/0.441
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3vthAPCCarbamoyltransferase/0.441
4ambDUDPutative glycosyl transferase/0.441
4ez8DHFThymidylate synthase2.1.1.450.441
4nh82LCHeat shock protein HSP 90-alpha/0.441
4pkl1GHUncharacterized protein/0.441
2bu9HFVIsopenicillin N synthase1.21.3.10.440
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.440
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4alg1GHBromodomain-containing protein 2/0.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4ipw1G7Mycocyclosin synthase1.14.21.90.440
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.440