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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.621
2hyySTITyrosine-protein kinase ABL12.7.10.20.542
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.533
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.530
4o2z046Mitogen-activated protein kinase/0.525
1iepSTITyrosine-protein kinase ABL12.7.10.20.513
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.512
2og81N8Tyrosine-protein kinase Lck2.7.10.20.507
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.502
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.495
3efl706Vascular endothelial growth factor receptor 22.7.10.10.492
4kaoKAOFocal adhesion kinase 12.7.10.20.490
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.486
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.480
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.479
3eta351Insulin receptor2.7.10.10.478
4aa0AA0Mitogen-activated protein kinase 14/0.478
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.477
3ctj320Hepatocyte growth factor receptor2.7.10.10.473
3hng8STVascular endothelial growth factor receptor 12.7.10.10.469
3ce31FNHepatocyte growth factor receptor2.7.10.10.464
3hv5R24Mitogen-activated protein kinase 14/0.461
4eyjN61Mitogen-activated protein kinase 132.7.11.240.458
3kq7KQ7Mitogen-activated protein kinase 14/0.456
4qrc0LIFibroblast growth factor receptor 42.7.10.10.454
4eevL1XHepatocyte growth factor receptor2.7.10.10.453
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.450
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.441