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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aguD15Cyclin-dependent kinase-like 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aguD15Cyclin-dependent kinase-like 1/1.000
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.524
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.520
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.520
3i60E86Mitogen-activated protein kinase 12.7.11.240.517
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.511
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.509
5cvfATPCasein kinase II subunit alpha2.7.11.10.508
1pjkANPCasein kinase II subunit alpha2.7.11.10.504
2vu3LZECyclin-dependent kinase 22.7.11.220.501
4bcmT7ZCyclin-dependent kinase 22.7.11.220.496
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.496
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
4j99ACPFibroblast growth factor receptor 2/0.493
4btjATPTau-tubulin kinase 12.7.11.10.492
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.491
4l9i8PRRhodopsin kinase/0.490
4qnyANPMitogen activated protein kinase, putative/0.489
3lltANPProtein serine/threonine kinase-1/0.488
4fv6E57Mitogen-activated protein kinase 12.7.11.240.485
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.483
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.483
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.481
3c4xATPRhodopsin kinase/0.480
2ojj82AMitogen-activated protein kinase 12.7.11.240.478
3at4CCKCasein kinase II subunit alpha2.7.11.10.477
3t8oATPRhodopsin kinase/0.477
2yaaATPDeath-associated protein kinase 2/0.474
4j95ACPFibroblast growth factor receptor 2/0.474
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.473
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.473
2fvdLIACyclin-dependent kinase 22.7.11.220.472
3q9xEMOCasein kinase II subunit alpha2.7.11.10.470
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.470
4ez50RSCyclin-dependent kinase 62.7.11.220.469
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.469
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.467
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.467
3my5RFZCyclin-dependent kinase 22.7.11.220.467
4anmWULCasein kinase II subunit alpha2.7.11.10.467
3u4uLNHCasein kinase II subunit alpha2.7.11.10.466
1jklANPDeath-associated protein kinase 12.7.11.10.465
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.464
4ji91M3Tyrosine-protein kinase JAK2/0.464
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.464
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.463
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.463
3lpbNVBTyrosine-protein kinase JAK2/0.462
2j0m4STFocal adhesion kinase 12.7.10.20.461
5dosATPAurora kinase A2.7.11.10.461
4o0wADNAurora kinase A2.7.11.10.460
2j0lANPFocal adhesion kinase 12.7.10.20.459
3be9P04Casein kinase II subunit alpha2.7.11.10.459
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.458
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
5av2KMPDeath-associated protein kinase 12.7.11.10.458
2w05FRTCyclin-dependent kinase 22.7.11.220.457
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.457
4eooATPCyclin-dependent kinase 22.7.11.220.457
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.456
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.456
4qmlANPSerine/threonine-protein kinase 242.7.11.10.455
5av3KMPDeath-associated protein kinase 12.7.11.10.455
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.454
2zjwREFCasein kinase II subunit alpha2.7.11.10.454
4btjADPTau-tubulin kinase 12.7.11.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
3begANPSRSF protein kinase 12.7.11.10.453
4grb0XGCasein kinase II subunit alpha2.7.11.10.453
4h3qANPMitogen-activated protein kinase 12.7.11.240.453
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
1fvv107Cyclin-dependent kinase 22.7.11.220.452
4c3pACPAurora kinase A2.7.11.10.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4hvi19STyrosine-protein kinase JAK32.7.10.20.451
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4e6d0NUTyrosine-protein kinase JAK2/0.450
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.449
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.449
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.449
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.448
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.448
4jia1K3Tyrosine-protein kinase JAK2/0.448
3zh8C58Protein kinase C iota type2.7.11.130.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.446
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
5dnrATPAurora kinase A2.7.11.10.445
2vtqLZACyclin-dependent kinase 22.7.11.220.444
2x6dX6DAurora kinase A2.7.11.10.444
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.444
4qo9627Serine/threonine-protein kinase 242.7.11.10.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2cjmATPCyclin-dependent kinase 22.7.11.220.443
2henADPEphrin type-B receptor 22.7.10.10.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.443
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4hgs15GCasein kinase I isoform gamma-32.7.11.10.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.442
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1qmzATPCyclin-dependent kinase 22.7.11.220.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
4deeADPAurora kinase A2.7.11.10.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4hge15VTyrosine-protein kinase JAK2/0.441
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.440
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.440