Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4afeGGYSerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4afeGGYSerine/threonine-protein kinase Nek22.7.11.11.000
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.802
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.673
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.590
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.562
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.558
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.540
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.506
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.505
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.490
2owb626Serine/threonine-protein kinase PLK12.7.11.210.478
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.477
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.477
2yac937Serine/threonine-protein kinase PLK12.7.11.210.476
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.470
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.469
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.468
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.466
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.464
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.457
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.456
3ihgVAKAklavinone 12-hydroxylase RdmE/0.455
4bfuZVUPantothenate kinase2.7.1.330.454
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.453
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.449
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.446
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.446
4g1nNZTPyruvate kinase PKM2.7.1.400.446
2bfpH4BPteridine reductase 11.5.1.330.445
3zsgT75Mitogen-activated protein kinase 14/0.443
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.442
3fznD7KBenzoylformate decarboxylase4.1.1.70.442
3hucG97Mitogen-activated protein kinase 14/0.442
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.441
2in6839Wee1-like protein kinase2.7.10.20.440
4eevL1XHepatocyte growth factor receptor2.7.10.10.440