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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4af3VX6Aurora kinase B2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4af3VX6Aurora kinase B2.7.11.11.000
4b8mVX6Aurora kinase B-A2.7.11.10.509
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.503
3e5aVX6Aurora kinase A2.7.11.10.490
3tdaPN0Cytochrome P450 2D6/0.486
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.478
4twpAXITyrosine-protein kinase ABL12.7.10.20.475
3qm4PN0Cytochrome P450 2D6/0.471
2j4z626Aurora kinase A2.7.11.10.465
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.461
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.461
4bb3KKAIsopenicillin N synthase1.21.3.10.458
4jbtASDCytochrome P450 monooxygenase/0.455
4j6cSTRCytochrome P450 monooxygenase/0.454
2c6eHPMAurora kinase A2.7.11.10.452
4qe6JN3Bile acid receptor/0.451
3oom507Activin receptor type-12.7.11.300.450
4j6bPLOCytochrome P450 monooxygenase/0.448
3l0lHC3Nuclear receptor ROR-gamma/0.447
4gmy0X5Tyrosine-protein kinase JAK2/0.445
3w2cN15Aurora kinase A2.7.11.10.443
1bygSTUTyrosine-protein kinase CSK/0.442
4kf1HT5Aryldialkylphosphatase3.1.8.10.441
2jb4A14Isopenicillin N synthase1.21.3.10.440