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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aacAAVMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aacAAVMitogen-activated protein kinase 14/1.000
4aa4QC0Mitogen-activated protein kinase 14/0.776
4aa5NQBMitogen-activated protein kinase 14/0.658
2balPQAMitogen-activated protein kinase 14/0.636
4kiq1RAMitogen-activated protein kinase 14/0.622
3fklFKLMitogen-activated protein kinase 14/0.602
3nww3NWMitogen-activated protein kinase 14/0.597
3iphG11Mitogen-activated protein kinase 14/0.588
3hl7I47Mitogen-activated protein kinase 14/0.582
3fln3FNMitogen-activated protein kinase 14/0.580
4kip1R9Mitogen-activated protein kinase 14/0.562
4lopSB4Mitogen-activated protein kinase 14/0.557
3mvl38PMitogen-activated protein kinase 14/0.554
3dt1P40Mitogen-activated protein kinase 14/0.544
2rg6287Mitogen-activated protein kinase 14/0.539
3fskRO6Mitogen-activated protein kinase 14/0.538
3ocgOCGMitogen-activated protein kinase 14/0.535
3mpt1GKMitogen-activated protein kinase 14/0.534
3hvcGG5Mitogen-activated protein kinase 14/0.533
3s4qNK0Mitogen-activated protein kinase 14/0.532
4kin1M8Mitogen-activated protein kinase 14/0.532
2rg5279Mitogen-activated protein kinase 14/0.528
3flwFLWMitogen-activated protein kinase 14/0.526
3uvqFS8Mitogen-activated protein kinase 14/0.526
4looSB4Mitogen-activated protein kinase 14/0.524
4loqSB4Mitogen-activated protein kinase 14/0.517
3fi4FI4Mitogen-activated protein kinase 14/0.514
3flyFLYMitogen-activated protein kinase 14/0.513
1zyjBI5Mitogen-activated protein kinase 14/0.509
3roc29AMitogen-activated protein kinase 14/0.509
3hllI45Mitogen-activated protein kinase 14/0.507
3flzFLZMitogen-activated protein kinase 14/0.506
3mpaSB2Mitogen-activated protein kinase 14/0.505
3uyt0CKCasein kinase I isoform delta2.7.11.10.499
3fmh533Mitogen-activated protein kinase 14/0.498
3u8w09JMitogen-activated protein kinase 14/0.496
3fmkFMKMitogen-activated protein kinase 14/0.491
1zz2B11Mitogen-activated protein kinase 14/0.489
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.485
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.483
3gfeP37Mitogen-activated protein kinase 14/0.481
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.478
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.478
2qd9LGFMitogen-activated protein kinase 14/0.477
4fod0UVALK tyrosine kinase receptor2.7.10.10.477
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.475
1ywrLI9Mitogen-activated protein kinase 14/0.474
4ic7ANPMitogen-activated protein kinase 72.7.11.240.474
4nk92K5Fibroblast growth factor receptor 1/0.472
3gc9B45Mitogen-activated protein kinase 112.7.11.240.471
3l8xN4DMitogen-activated protein kinase 14/0.471
4ewqMWLMitogen-activated protein kinase 14/0.470
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.469
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.468
3mvm39PMitogen-activated protein kinase 14/0.467
3gu83GUDeath-associated protein kinase 12.7.11.10.466
4kb81QOCasein kinase I isoform delta2.7.11.10.465
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.464
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.463
3w33W19Epidermal growth factor receptor2.7.10.10.463
2ghlLIBMitogen-activated protein kinase 14/0.461
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.458
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.457
1unlRRCCyclin-dependent-like kinase 52.7.11.10.456
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.456
4b99R4LMitogen-activated protein kinase 72.7.11.240.456
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.454
3kf7L9GMitogen-activated protein kinase 14/0.454
4fob0USALK tyrosine kinase receptor2.7.10.10.454
4kbc1QJCasein kinase I isoform delta2.7.11.10.454
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
4i22IREEpidermal growth factor receptor2.7.10.10.453
4yuqKS1Calmodulin-like domain protein kinase/0.453
4f650S9Fibroblast growth factor receptor 1/0.452
1eh4IC1Casein kinase I homolog 12.7.11.10.451
3itzP66Mitogen-activated protein kinase 14/0.451
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.451
3zh8C58Protein kinase C iota type2.7.11.130.451
1ouk084Mitogen-activated protein kinase 14/0.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
3bv3P39Mitogen-activated protein kinase 14/0.450
3gubGUBDeath-associated protein kinase 12.7.11.10.450
1u4dDBQActivated CDC42 kinase 1/0.449
3gw9VNILanosterol 14-alpha-demethylase/0.449
3uvp048Mitogen-activated protein kinase 14/0.449
2itpAEEEpidermal growth factor receptor2.7.10.10.448
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
2zb0GK3Mitogen-activated protein kinase 14/0.447
3uibSB2Putative mitogen-activated protein kinase/0.447
3vs1VSATyrosine-protein kinase HCK2.7.10.20.447
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.447
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.446
2j0lANPFocal adhesion kinase 12.7.10.20.446
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
1jumBERHTH-type transcriptional regulator QacR/0.445
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.445
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.445
3hp552PMitogen-activated protein kinase 14/0.445
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.444
2zb1GK4Mitogen-activated protein kinase 14/0.444
4eh70OOMitogen-activated protein kinase 14/0.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
1gih1PUCyclin-dependent kinase 22.7.11.220.443
1w2xRCPAcetyl-CoA carboxylase/0.443
1yw2PGJMitogen-activated protein kinase 14/0.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4foc0UUALK tyrosine kinase receptor2.7.10.10.443
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.442
3ol5SAWCamphor 5-monooxygenase1.14.15.10.442
4hnf16WCasein kinase I isoform delta2.7.11.10.442
4kb81QNCasein kinase I isoform delta2.7.11.10.442
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.440
1xl5190Gag-Pol polyprotein3.4.23.160.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.440