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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aa5NQBMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aa5NQBMitogen-activated protein kinase 14/1.000
4aa4QC0Mitogen-activated protein kinase 14/0.685
4aacAAVMitogen-activated protein kinase 14/0.662
3nww3NWMitogen-activated protein kinase 14/0.649
4kiq1RAMitogen-activated protein kinase 14/0.615
3fklFKLMitogen-activated protein kinase 14/0.600
2qd9LGFMitogen-activated protein kinase 14/0.598
3iphG11Mitogen-activated protein kinase 14/0.595
3fln3FNMitogen-activated protein kinase 14/0.583
3mpt1GKMitogen-activated protein kinase 14/0.580
2balPQAMitogen-activated protein kinase 14/0.577
4lopSB4Mitogen-activated protein kinase 14/0.575
3hl7I47Mitogen-activated protein kinase 14/0.571
3fskRO6Mitogen-activated protein kinase 14/0.567
3dt1P40Mitogen-activated protein kinase 14/0.564
2rg5279Mitogen-activated protein kinase 14/0.556
4kin1M8Mitogen-activated protein kinase 14/0.552
4kip1R9Mitogen-activated protein kinase 14/0.547
1zz2B11Mitogen-activated protein kinase 14/0.544
3mvl38PMitogen-activated protein kinase 14/0.544
2rg6287Mitogen-activated protein kinase 14/0.543
3flwFLWMitogen-activated protein kinase 14/0.543
3flyFLYMitogen-activated protein kinase 14/0.537
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.534
3fmh533Mitogen-activated protein kinase 14/0.534
4looSB4Mitogen-activated protein kinase 14/0.534
3uvqFS8Mitogen-activated protein kinase 14/0.533
3fi4FI4Mitogen-activated protein kinase 14/0.532
3ocgOCGMitogen-activated protein kinase 14/0.530
3fmkFMKMitogen-activated protein kinase 14/0.525
3hvcGG5Mitogen-activated protein kinase 14/0.522
4loqSB4Mitogen-activated protein kinase 14/0.520
3l8xN4DMitogen-activated protein kinase 14/0.517
3flzFLZMitogen-activated protein kinase 14/0.514
3mpaSB2Mitogen-activated protein kinase 14/0.505
3w33W19Epidermal growth factor receptor2.7.10.10.505
3hllI45Mitogen-activated protein kinase 14/0.504
3s4qNK0Mitogen-activated protein kinase 14/0.504
1zyjBI5Mitogen-activated protein kinase 14/0.502
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.494
3mvm39PMitogen-activated protein kinase 14/0.494
3roc29AMitogen-activated protein kinase 14/0.494
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.492
3u8w09JMitogen-activated protein kinase 14/0.491
3uyt0CKCasein kinase I isoform delta2.7.11.10.487
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.486
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.484
2zb0GK3Mitogen-activated protein kinase 14/0.484
3uvp048Mitogen-activated protein kinase 14/0.481
3gc9B45Mitogen-activated protein kinase 112.7.11.240.480
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.479
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.478
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2ghlLIBMitogen-activated protein kinase 14/0.472
3hp552PMitogen-activated protein kinase 14/0.471
1m17AQ4Epidermal growth factor receptor2.7.10.10.470
1ouk084Mitogen-activated protein kinase 14/0.466
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.465
4nks2M2Fibroblast growth factor receptor 1/0.465
1yw2PGJMitogen-activated protein kinase 14/0.464
2itpAEEEpidermal growth factor receptor2.7.10.10.464
4b99R4LMitogen-activated protein kinase 72.7.11.240.464
1ywrLI9Mitogen-activated protein kinase 14/0.463
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.463
3kf7L9GMitogen-activated protein kinase 14/0.463
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.463
4kbc1QJCasein kinase I isoform delta2.7.11.10.463
4nk92K5Fibroblast growth factor receptor 1/0.463
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.460
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
4f650S9Fibroblast growth factor receptor 1/0.460
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.459
3bv3P39Mitogen-activated protein kinase 14/0.458
3gc7B45Mitogen-activated protein kinase 14/0.457
3gfeP37Mitogen-activated protein kinase 14/0.457
4eh60ONMitogen-activated protein kinase 14/0.457
4eh70OOMitogen-activated protein kinase 14/0.457
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2itnANPEpidermal growth factor receptor2.7.10.10.455
4hjoAQ4Epidermal growth factor receptor2.7.10.10.455
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.454
3fmn530Mitogen-activated protein kinase 14/0.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.453
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
4dymIYZActivin receptor type-12.7.11.300.451
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
4i22IREEpidermal growth factor receptor2.7.10.10.450
3gubGUBDeath-associated protein kinase 12.7.11.10.449
4nka2K7Fibroblast growth factor receptor 1/0.449
4jq7KJQEpidermal growth factor receptor2.7.10.10.448
4id71G0Activated CDC42 kinase 1/0.447
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2of2547Tyrosine-protein kinase Lck2.7.10.20.446
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.445
2qo9ANPEphrin type-A receptor 32.7.10.10.445
2y6o1N1Ephrin type-A receptor 42.7.10.10.445
3vryB43Tyrosine-protein kinase HCK2.7.10.20.445
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4kbk1QGCasein kinase I isoform delta2.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
3uibSB2Putative mitogen-activated protein kinase/0.444
3uzp0CKCasein kinase I isoform delta2.7.11.10.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
2gtnLIEMitogen-activated protein kinase 14/0.443
4qmzB49Serine/threonine-protein kinase 242.7.11.10.443
4tuvCPZCytochrome P450 1191.140.443
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.442
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.442
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.442
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
4fod0UVALK tyrosine kinase receptor2.7.10.10.442
3lfeZ84Mitogen-activated protein kinase 14/0.441
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.441
4c02TAKActivin receptor type-12.7.11.300.441
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
4yuqKS1Calmodulin-like domain protein kinase/0.440