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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aa0AA0Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aa0AA0Mitogen-activated protein kinase 14/1.000
3kq7KQ7Mitogen-activated protein kinase 14/0.594
3hv5R24Mitogen-activated protein kinase 14/0.542
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.527
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.506
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.506
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.503
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.502
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.499
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.497
4o2z046Mitogen-activated protein kinase/0.487
3efl706Vascular endothelial growth factor receptor 22.7.10.10.476
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.474
1iepSTITyrosine-protein kinase ABL12.7.10.20.461
2hyySTITyrosine-protein kinase ABL12.7.10.20.461
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.459
3hng8STVascular endothelial growth factor receptor 12.7.10.10.453
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.446
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.441
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.440