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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a9e3PFBromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a9e3PFBromodomain-containing protein 2/1.000
4a9mP9MBromodomain-containing protein 2/0.747
4a9hTVPBromodomain-containing protein 2/0.613
2ydwWSHBromodomain-containing protein 2/0.549
4o761M3Bromodomain-containing protein 4/0.549
4a9iP9IBromodomain-containing protein 2/0.539
4alhA9PBromodomain-containing protein 2/0.533
4o71CPBBromodomain-containing protein 4/0.528
4o701QKBromodomain-containing protein 4/0.521
4uyf73BBromodomain-containing protein 2/0.518
3nx4NAPPutative oxidoreductase/0.480
4c67L5SBromodomain-containing protein 4/0.472
4a9nA9NBromodomain-containing protein 2/0.471
4aknS5BBromodomain-containing protein 2/0.470
1fmlRTLRetinol dehydratase/0.468
3iaeD7KBenzaldehyde lyase/0.467
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.462
4flpJQ1Bromodomain testis-specific protein/0.461
1dhjMTXDihydrofolate reductase1.5.1.30.460
3t2yFADSulfide-quinone reductase/0.459
3t14FADSulfide-quinone reductase/0.457
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.456
4g1z0VPVitamin D3 receptor A/0.455
4py6R78Bromodomain protein, putative/0.455
1pkfEPDEpothilone C/D epoxidase1.140.454
2g5cNADPrephenate dehydrogenase/0.454
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
3kpkFADSulfide-quinone reductase/0.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.451
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.451
4hxs1A3Bromodomain-containing protein 4/0.451
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.450
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.450
4jx1CAHCamphor 5-monooxygenase1.14.15.10.450
3aqaBYHBromodomain-containing protein 2/0.448
3s7a684Dihydrofolate reductase1.5.1.30.448
1y0s331Peroxisome proliferator-activated receptor delta/0.447
4gevCB3Thymidylate synthase/0.447
3drcMTXDihydrofolate reductase1.5.1.30.446
4k2xFADPolyketide oxygenase/hydroxylase/0.444
2qa2FADPolyketide oxygenase CabE/0.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
3gstGPRGlutathione S-transferase Mu 12.5.1.180.442
4iteTEYVitamin D3 receptor/0.442
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.442
1x8lOXRRetinol dehydratase/0.441
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.441
4g7gVFVLanosterol 14-alpha-demethylase/0.441
2pvlP55Casein kinase II subunit alpha2.7.11.10.440
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3sz0FADSulfide-quinone reductase/0.440
3vt5YI2Vitamin D3 receptor/0.440
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4mr61K0Bromodomain-containing protein 2/0.440
4r21STRCytochrome P450 family 17 polypeptide 2/0.440