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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a7yNHFAldos-2-ulose dehydratase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a7yNHFAldos-2-ulose dehydratase/1.000
4a7zAY9Aldos-2-ulose dehydratase/0.708
1ry0PG2Aldo-keto reductase family 1 member C3/0.480
4bfsZVSPantothenate kinase2.7.1.330.467
3dr7GPDGDP-perosamine synthase/0.461
4bftZVTPantothenate kinase2.7.1.330.459
4bfxZVXPantothenate kinase2.7.1.330.455
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.455
2geuCOKPantothenate kinase2.7.1.330.451
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.450
4dbw511Aldo-keto reductase family 1 member C3/0.450
1gpnHUBAcetylcholinesterase3.1.1.70.445
4n9qFMNFMN-dependent NADH-azoreductase 1/0.445
4mv1ADPBiotin carboxylase6.3.4.140.443
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.443
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.440
4h7c10HAldo-keto reductase family 1 member C3/0.440