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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a65FADThioredoxin reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a65FADThioredoxin reductase/1.000
4up3FADThioredoxin reductase/0.642
4cbqFADThioredoxin reductase/0.635
4ccrFADThioredoxin reductase/0.595
4a5lFADThioredoxin reductase/0.563
3itjFADThioredoxin reductase 11.8.1.90.531
3f8dFADNADH oxidase/thioredoxin reductase/0.500
1tdfFADThioredoxin reductase1.8.1.90.499
1cl0FADThioredoxin reductase1.8.1.90.493
1tdeFADThioredoxin reductase1.8.1.90.488
3ishFADThioredoxin reductase1.8.1.90.487
4ccqFADThioredoxin reductase/0.480
4jnqFDAThioredoxin reductase/0.480
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.475
3kpkFADSulfide-quinone reductase/0.472
3sz0FADSulfide-quinone reductase/0.469
1galFADGlucose oxidase1.1.3.40.468
1ryiFADGlycine oxidase1.4.3.190.468
4o5qFADAlkyl hydroperoxide reductase subunit F1.8.10.467
2du8FADD-amino-acid oxidase1.4.3.30.466
2q0kFADThioredoxin reductase1.8.1.90.465
4ykfFADAlkyl hydroperoxide reductase subunit F1.8.10.464
5j60FADThioredoxin reductase/0.463
3bg7FADPyranose 2-oxidase/0.457
4qi4FADCellobiose dehydrogenase/0.457
3t2kFADSulfide-quinone reductase/0.456
2ignFADPyranose 2-oxidase/0.453
4jq9FADDihydrolipoyl dehydrogenase/0.453
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.452
3ctyFADProbable thioredoxin reductase/0.451
1f8rFADL-amino-acid oxidase1.4.3.20.449
2e48FADD-amino-acid oxidase1.4.3.30.449
1trbFADThioredoxin reductase1.8.1.90.447
1xdiFADNAD(P)H dehydrogenase (quinone)/0.447
3kkjFADRenalase/0.446
3t14FADSulfide-quinone reductase/0.446
1cc2FADCholesterol oxidase1.1.3.60.444
2babFADPutative aminooxidase/0.443
2q0lFADThioredoxin reductase1.8.1.90.442
3syiFADSulfide-quinone reductase/0.442
3b70NAPEnoyl reductase LovC10.441
4gcmFADThioredoxin reductase1.8.1.90.441
4qi5FADCellobiose dehydrogenase/0.441
2c7gFADNADPH-ferredoxin reductase FprA1.18.1.20.440