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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a4qUX9Pol protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4a4qUX9Pol protein/1.000
3zpuM8BGag-Pol polyprotein3.4.23.160.709
3zpsEQMGag-Pol polyprotein3.4.23.160.696
2pk5075Protease/0.648
1ec3MS3Gag-Pol polyprotein3.4.23.160.646
3zptM8YGag-Pol polyprotein3.4.23.160.643
4a6bQG8Gag-Pol polyprotein3.4.23.160.638
2bqvA1AProtease/0.621
4hdfG52Gag-Pol polyprotein3.4.23.160.621
2bpv1INGag-Pol polyprotein3.4.23.160.620
1vikBAYGag-Pol polyprotein/0.619
1ebwBEIGag-Pol polyprotein3.4.23.160.617
2cen4AHProtease/0.610
1iiq0ZRGag-Pol polyprotein3.4.23.160.609
2cem2AHPol protein/0.607
1d4sTPVGag-Pol polyprotein3.4.23.160.601
4kb9G79Protease/0.601
2a4fAAUV-1 protease/0.598
1ec2BEJGag-Pol polyprotein3.4.23.160.597
2xyfG40Gag-Pol polyprotein/0.594
2bpw1INGag-Pol polyprotein3.4.23.160.589
2upjU02Gag-Pol polyprotein3.4.23.160.589
1ebyBEBGag-Pol polyprotein3.4.23.160.588
2aquDR7Gag-Pol polyprotein3.4.23.160.585
1ec1BEEGag-Pol polyprotein3.4.23.160.583
2uxzHI1Gag-Pol polyprotein3.4.23.160.583
3ndtROCGag-Pol polyprotein3.4.23.160.582
1hvkA79Gag-Pol polyprotein/0.579
3ggaGGWGag-Pol polyprotein/0.576
1rl8RITGag-Pol polyprotein3.4.23.160.575
1d4yTPVGag-Pol polyprotein3.4.23.160.574
1w5xBE5Gag-Pol polyprotein3.4.23.160.574
2xyeCXGGag-Pol polyprotein/0.574
4njvRITProtease/0.574
2pk6O33V-1 protease/0.573
1d4jMSCGag-Pol polyprotein3.4.23.160.571
2ieo017Protease/0.571
1tcxIM1Gag-Pol polyprotein3.4.23.160.570
2fxeDR7Gag-Pol polyprotein3.4.23.160.570
2ien017Gag-Pol polyprotein3.4.23.160.570
2p3b3TLV-1 PROTEASE protein/0.570
2p3b3TLV-1 protease/0.570
2uy0HV1Gag-Pol polyprotein3.4.23.160.570
3kdcJZPGag-Pol polyprotein3.4.23.160.569
1difA85Gag-Pol polyprotein/0.567
3ggxGGXGag-Pol polyprotein/0.567
1hvlA76Gag-Pol polyprotein/0.566
3tl9ROCGag-Pol polyprotein3.4.23.160.566
2wl05AHGag-Pol polyprotein/0.565
3i2l2NCProtease/0.565
3k4vROCGag-Pol polyprotein3.4.23.160.565
3s85LK0Gag-Pol polyprotein/0.565
3ndxRITGag-Pol polyprotein3.4.23.160.564
3a2oKNJGag-Pol polyprotein3.4.23.160.562
4rvj478Protease/0.559
2qd6065Gag-Pol polyprotein3.4.23.160.558
3oxxDR7Gag-Pol polyprotein3.4.23.160.558
1ebzBECGag-Pol polyprotein3.4.23.160.557
2aoe0Q4Gag-Pol polyprotein3.4.23.160.557
3ok9G52Gag-Pol polyprotein3.4.23.160.557
2f81017Gag-Pol polyprotein3.4.23.160.556
4qgiROCGag-Pol polyprotein3.4.23.160.556
1xl5190Gag-Pol polyprotein3.4.23.160.555
3em4DR7Gag-Pol polyprotein3.4.23.160.555
3sa755AProtease/0.555
3mxeK54Gag-Pol polyprotein3.4.23.160.554
1t7i017Gag-Pol polyprotein3.4.23.160.553
2nmyROCProtease/0.553
2fdd385Pol protein/0.552
2bpz3INGag-Pol polyprotein3.4.23.160.551
1w5yBE6Gag-Pol polyprotein3.4.23.160.550
4dfg0JVGag-Pol polyprotein3.4.23.160.550
1hvjA78Gag-Pol polyprotein/0.549
3kfn3TLGag-Pol polyprotein/0.549
3lzs017Gag-Pol polyprotein3.4.23.160.549
4djoMK5Pol polyprotein/0.549
3ekqROCGag-Pol polyprotein3.4.23.160.548
7upjINUGag-Pol polyprotein3.4.23.160.548
1wbmBLLPol protein/0.547
2fxdDR7Pol polyprotein/0.547
3ndwRITGag-Pol polyprotein3.4.23.160.547
4njuTPVProtease/0.547
2a1eIPFGag-Pol polyprotein3.4.23.160.546
2bpy3INGag-Pol polyprotein3.4.23.160.546
1hosPHPGag-Pol polyprotein/0.545
1ivp1ZKGag-Pol polyprotein/0.545
1sdvMK1Gag-Pol polyprotein3.4.23.160.545
2nnkROCProtease/0.545
2qnnQN1Gag-Pol polyprotein3.4.23.160.545
2pqzG0GGag-Pol polyprotein3.4.23.160.544
3ekp478Gag-Pol polyprotein3.4.23.160.544
1k2b0Q4Gag-Pol polyprotein3.4.23.160.541
3ekt017Gag-Pol polyprotein3.4.23.160.541
3oxcROCProtease/0.541
1vijBAYGag-Pol polyprotein/0.540
3kf03TLGag-Pol polyprotein/0.540
2qd8065Gag-Pol polyprotein3.4.23.160.539
3em3478Gag-Pol polyprotein3.4.23.160.539
3nxe2NCProtease/0.539
4ye3G04Gag-Pol polyprotein3.4.23.160.539
1ec0BEDGag-Pol polyprotein3.4.23.160.538
1k1u0Q4Gag-Pol polyprotein3.4.23.160.538
1wbk568Pol protein/0.538
1yt9OISGag-Pol polyprotein/0.538
3dk1G05Gag-Pol polyprotein3.4.23.160.538
3hzc2NCProtease/0.538
2idw017Protease/0.537
3d1yROCGag-Pol polyprotein3.4.23.160.537
3nyg2NCGag-Pol polyprotein3.4.23.160.537
2z54AB1Gag-Pol polyprotein3.4.23.160.536
3kddJZQGag-Pol polyprotein3.4.23.160.536
3pwm017Gag-Pol polyprotein3.4.23.160.535
1c6zROCProtease/0.534
1hviA77Protease/0.534
3sa323XProtease/0.534
1ff02NCGag-Pol polyprotein3.4.23.160.533
1fgc2NCGag-Pol polyprotein3.4.23.160.533
1zsr0ZTGag-Pol polyprotein3.4.23.160.533
2wkz5AHGag-Pol polyprotein/0.533
3linE13Protease/0.533
4gb20LQGag-Pol polyprotein2.7.7.490.533
3sabF78Protease/0.532
3vfa031Gag-Pol polyprotein3.4.23.160.532
3nduROCGag-Pol polyprotein3.4.23.160.531
3uhl2NCGag-Pol polyprotein3.4.23.160.531
1hvsA77Gag-Pol polyprotein/0.530
3bva2NCGag-Pol polyprotein3.4.23.160.530
3kfs3TLGag-Pol polyprotein/0.530
3sa4F72Protease/0.530
3ttp017Gag-Pol polyprotein3.4.23.160.530
1d4kPI8Gag-Pol polyprotein3.4.23.160.529
1daz0Q4Gag-Pol polyprotein3.4.23.160.529
1fg62NCGag-Pol polyprotein3.4.23.160.529
1hiv1ZKGag-Pol polyprotein/0.529
2b7zMK1Gag-Pol polyprotein/0.529
2qi3MZ5Gag-Pol polyprotein/0.529
4djpM73Pol polyprotein/0.529
2qd7065Gag-Pol polyprotein3.4.23.160.528
3ekwDR7Gag-Pol polyprotein3.4.23.160.528
3jw2017Gag-Pol polyprotein3.4.23.160.528
4i8zG08Gag-Pol polyprotein3.4.23.160.527
3d1xROCGag-Pol polyprotein3.4.23.160.526
3kfr3TLGag-Pol polyprotein/0.526
3vfb031Gag-Pol polyprotein3.4.23.160.526
4djqM86Pol polyprotein/0.526
1d4hBEHGag-Pol polyprotein3.4.23.160.525
1ohr1UNV-1 PROTEASE protein/0.525
1sh9RITGag-Pol polyprotein3.4.23.160.525
1b6kPI5Gag-Pol polyprotein3.4.23.160.524
1hshMK1Gag-Pol polyprotein/0.524
2i4wKGQProtease/0.524
3nu9478Gag-Pol polyprotein3.4.23.160.524
1c70L75Protease/0.523
1ffi2NCGag-Pol polyprotein3.4.23.160.523
3sacAF8Protease/0.523
1b6pPI7Gag-Pol polyprotein3.4.23.160.522
1hxbROCGag-Pol polyprotein3.4.23.160.522
1npa3NHGag-Pol polyprotein3.4.23.160.522
1npwLGZGag-Pol polyprotein3.4.23.160.522
2f3kRO1Protease/0.522
3dcrKVSProtease/0.522
3sa5A69Protease/0.522
3sa9A68Protease/0.522
4djr0KJPol polyprotein/0.522
4hdbG52Gag-Pol polyprotein3.4.23.160.522
4hdpG52Gag-Pol polyprotein3.4.23.160.522
1sbgIM1Gag-Pol polyprotein/0.521
3nwq2NCGag-Pol polyprotein3.4.23.160.521
1hxwRITGag-Pol polyprotein/0.520
3s54017Protease/0.520
3vf5031Gag-Pol polyprotein3.4.23.160.520
1dw60Q4Gag-Pol polyprotein3.4.23.160.519
1jld0PPGag-Pol polyprotein/0.519
2f8g017Gag-Pol polyprotein3.4.23.160.519
3cyxROCGag-Pol polyprotein3.4.23.160.519
3pwrROCGag-Pol polyprotein3.4.23.160.519
3tog079Gag-Pol polyprotein2.7.7.490.519
2avm2NCGag-Pol polyprotein3.4.23.160.518
2qi7MZ9Gag-Pol polyprotein/0.518
2r5pMK1Gag-Pol polyprotein/0.518
2fde385Gag-Pol polyprotein3.4.23.160.517
2p3d3TLProtease/0.517
3bgbLJGGag-Pol polyprotein3.4.23.160.517
3dckKVIProtease/0.517
3ekyDR7Gag-Pol polyprotein3.4.23.160.517
3el51UNGag-Pol polyprotein/0.517
3em6017Gag-Pol polyprotein3.4.23.160.517
1m0b0ZQGag-Pol polyprotein3.4.23.160.516
3fx5KNIGag-Pol polyprotein3.4.23.160.516
3gi4K60Gag-Pol polyprotein/0.516
1hsgMK1Gag-Pol polyprotein/0.515
2rkfAB1Pol protein/0.515
3o9cK20Pol polyprotein/0.515
3st5G89Gag-Pol polyprotein3.4.23.160.515
4hegG52Gag-Pol polyprotein3.4.23.160.515
1fg80Q4Gag-Pol polyprotein3.4.23.160.514
2cej1AHPol protein/0.514
2qi6MZ8Gag-Pol polyprotein/0.514
3bvb017Gag-Pol polyprotein3.4.23.160.514
1bai0Q4Gag-Pro polyprotein/0.513
1d4iBEGGag-Pol polyprotein3.4.23.160.513
3nu4478Gag-Pol polyprotein3.4.23.160.513
4j55031Gag-Pol polyprotein3.4.23.160.513
1bdrIM1Gag-Pol polyprotein3.4.23.160.512
1w5vBE3Gag-Pol polyprotein3.4.23.160.512
2qi5MZ7Gag-Pol polyprotein/0.512
3el9DR7Gag-Pol polyprotein3.4.23.160.512
2bb9AKCGag-Pol polyprotein3.4.23.160.511
2hb3GRLProtease/0.511
2i4dQFIProtease/0.511
2nnpROCProtease/0.511
2qhcAB1Protease/0.511
3sa8K83Protease/0.511
3liqE14Protease/0.510
4a6cQG9Gag-Pol polyprotein3.4.23.160.510
2hs2017Protease/0.509
2qnpQN2Gag-Pol polyprotein3.4.23.160.509
3lzu017Gag-Pol polyprotein3.4.23.160.509
3oxw017Gag-Pol polyprotein3.4.23.160.509
9hvp0E9Gag-Pol polyprotein/0.509
1a940Q4Gag-Pol polyprotein3.4.23.160.508
1ajvNMBGag-Pol polyprotein3.4.23.160.508
1izhQ50Protease/0.508
1sdtMK1Gag-Pol polyprotein3.4.23.160.508
2avsMK1Gag-Pol polyprotein3.4.23.160.508
2b60RITPol polyprotein/0.508
3gi6D78Gag-Pol polyprotein/0.508
3nuo478Gag-Pol polyprotein3.4.23.160.508
3o9gF53Gag-Pol polyprotein/0.508
4dqc017Gag-Pol polyprotein/0.508
4j5j478Gag-Pol polyprotein3.4.23.160.508
1k6vXN2Gag-Pol polyprotein3.4.23.160.507
1n49RITGag-Pol polyprotein3.4.23.160.507
2qhzMZ2Gag-Pol polyprotein/0.507
3cyw017Gag-Pol polyprotein3.4.23.160.507
3nls016Gag-Pol polyprotein3.4.23.160.507
3o9fK2DGag-Pol polyprotein/0.507
3s56ROCProtease/0.507
2f80017Gag-Pol polyprotein3.4.23.160.506
3cktYDPGag-Pol polyprotein3.4.23.160.506
1fej2NCGag-Pol polyprotein3.4.23.160.505
2avvMK1Gag-Pol polyprotein3.4.23.160.505
2o4pTPVProtease/0.505
3jvwDMPGag-Pol polyprotein3.4.23.160.505
3o9bK2APol polyprotein/0.505
3s43478Protease/0.505
1a9mU0EGag-Pol polyprotein/0.504
1hiiC20Gag-Pol polyprotein/0.504
1sguMK1Gag-Pol polyprotein3.4.23.160.504
1z1hHBBGag-Pol polyprotein3.4.23.160.504
2q5kAB1Protease/0.504
2q641UNGag-Pol polyprotein3.4.23.160.504
1a8k0Q4Gag-Pol polyprotein3.4.23.160.503
1ida0POGag-Pol polyprotein3.4.23.470.503
2i4uDJRProtease/0.503
2i4xKGQProtease/0.503
2qci065Gag-Pol polyprotein3.4.23.160.503
3el4ROCGag-Pol polyprotein3.4.23.160.503
1mtrPI6Gag-Pol polyprotein3.4.23.160.502
1odw0E8Gag-Pol polyprotein3.4.23.160.502
2bpxMK1Gag-Pol polyprotein3.4.23.160.502
3aidARQGag-Pol polyprotein3.4.23.160.502
3gi5K62Gag-Pol polyprotein/0.502
3t3c017Gag-Pol polyprotein3.4.23.160.502
4dqe017Gag-Pol polyprotein/0.502
4njsG08Protease/0.502
1iziQ50Gag-Pol polyprotein3.4.23.160.501
1z1rHBHGag-Pol polyprotein3.4.23.160.501
2aidTHKGag-Pol polyprotein3.4.23.160.501
2i4vDJRV-1 protease/0.500
2qnqQN3Gag-Pol polyprotein3.4.23.160.500
2r5q1UNGag-Pol polyprotein/0.500
3ggu017Gag-Pol polyprotein3.4.23.160.500
3o9eA60Pol polyprotein/0.500
1b6mPI6Gag-Pol polyprotein3.4.23.160.499
3djkG55Gag-Pol polyprotein3.4.23.160.499
3nwxKVSGag-Pol polyprotein3.4.23.160.499
3qn8NI7Gag-Pol polyprotein3.4.23.160.499
3sa6F71Protease/0.499
3saa77FProtease/0.499
3vf7031Gag-Pol polyprotein3.4.23.160.499
2q3kMUWGag-Pol polyprotein/0.498
2qak1UNGag-Pol polyprotein3.4.23.160.498
3livE16Protease/0.498
1c6x3INProtease/0.497
1g35AHFGag-Pol polyprotein3.4.23.160.497
1msmJE2Gag-Pol polyprotein3.4.23.160.497
1odyLP1Gag-Pol polyprotein3.4.23.160.497
2pyn1UNGag-Pol polyprotein3.4.23.160.497
3qp0NI8Gag-Pol polyprotein3.4.23.160.497
4njt017Protease/0.497
4q1y017Gag-Pol polyprotein3.4.23.160.497
1d4lPI9Gag-Pol polyprotein3.4.23.160.496
3o9dK19Pol polyprotein/0.496
1muiAB1Protease/0.495
1sduMK1Gag-Pol polyprotein3.4.23.160.495
3ekv478Gag-Pol polyprotein3.4.23.160.495
3litE15Protease/0.495
1fff0Q4Gag-Pol polyprotein3.4.23.160.494
1zsf0ZSGag-Pol polyprotein3.4.23.160.494
2hc0AB2Protease/0.494
2q54MU1Protease/0.494
3d1z017Gag-Pol polyprotein3.4.23.160.494
3el1DR7Gag-Pol polyprotein3.4.23.160.494
3i6oGR6Gag-Pol polyprotein3.4.23.160.494
3oxv478Gag-Pol polyprotein3.4.23.160.494
1hpoUNIGag-Pol polyprotein3.4.23.160.492
3oy4017Gag-Pol polyprotein3.4.23.160.492
3toh079Gag-Pol polyprotein2.7.7.490.492
1mesDMPGag-Pol polyprotein3.4.23.160.491
3o9iA61Gag-Pol polyprotein/0.491
4k4p3TLGag-Pol polyprotein/0.491
1t3r017Gag-Pol polyprotein3.4.23.160.490
1a8g2Z4Gag-Pol polyprotein3.4.23.160.489
1ajxAH1Gag-Pol polyprotein3.4.23.160.488
1idb0DOGag-Pol polyprotein/0.488
3ufnROCGag-Pol polyprotein/0.488
1bv7XV6Gag-Pol polyprotein3.4.23.160.487
1hpxKNIGag-Pol polyprotein/0.487
2p3c3TLProtease/0.487
3jvy017Gag-Pol polyprotein3.4.23.160.487
1g2kNM1Gag-Pol polyprotein3.4.23.160.486
2qi4MZ6Gag-Pol polyprotein/0.486
3bgcLJHGag-Pol polyprotein3.4.23.160.486
3qbfJHGGag-Pol polyprotein3.4.23.160.486
3r4b74TGag-Pol polyprotein/0.486
2fleAIProtease/0.485
4q1w017Gag-Pol polyprotein3.4.23.160.485
3mws017Pol protein/0.484
2qhyMZ1Gag-Pol polyprotein/0.483
4dqh017Gag-Pol polyprotein/0.482
1hihC20Gag-Pol polyprotein/0.481
1kzkJE2Gag-Pol polyprotein3.4.23.160.481
3qrmNK7Gag-Pol polyprotein3.4.23.160.481
1c6yMK1Protease/0.480
1proA88Gag-Pol polyprotein/0.480
2bbbHH1Gag-Pol polyprotein3.4.23.160.480
2p3a3TLPol protein/0.480
2z4o065Gag-Pol polyprotein3.4.23.160.480
3lixE17Protease/0.480
2qi0MZ3Gag-Pol polyprotein/0.479
3qaaG04Gag-Pol polyprotein3.4.23.160.479
3upjU03Gag-Pol polyprotein/0.479
3mxdK53Gag-Pol polyprotein3.4.23.160.478
1mrwK57Gag-Pol polyprotein3.4.23.160.477
2r38G4GGag-Pol polyprotein3.4.23.160.477
2r43G3GGag-Pol polyprotein3.4.23.160.477
3nu5478Gag-Pol polyprotein3.4.23.160.477
1bwaXV6Gag-Pol polyprotein3.4.23.160.476
1ebk0Q4Gag-Pol polyprotein3.4.23.160.476
1ivq0PXGag-Pol polyprotein/0.476
1meuDMPGag-Pol polyprotein3.4.23.160.476
1qbrXV6Gag-Pol polyprotein3.4.23.160.476
1qbu846Gag-Pol polyprotein3.4.23.160.476
1t7kBH0Gag-Pol polyprotein3.4.23.160.476
2qi1MZ4Gag-Pol polyprotein/0.476
3qroNK9Gag-Pol polyprotein3.4.23.160.476
6upjNIUGag-Pol polyprotein/0.476
3o9aK14Pol polyprotein/0.475
1b6lPI4Gag-Pol polyprotein3.4.23.160.474
1bdqIM1Gag-Pol polyprotein3.4.23.160.474
1hvrXK2Gag-Pol polyprotein/0.474
3i7eDJRGag-Pol polyprotein/0.474
3so9017Pol protein/0.474
1hbvGANGag-Pol polyprotein/0.473
1sivPSIGag-Pol polyprotein/0.473
2psuMUUProtease/0.473
3ekx1UNGag-Pol polyprotein3.4.23.160.473
3qrsNK8Gag-Pol polyprotein3.4.23.160.473
4hla017Gag-Pol polyprotein3.4.23.160.473
2r3wG3GGag-Pol polyprotein3.4.23.160.472
3o9hK2EGag-Pol polyprotein/0.472
3ucb017Gag-Pol polyprotein/0.472
1msnJE2Gag-Pol polyprotein3.4.23.160.471
3d20017Gag-Pol polyprotein3.4.23.160.471
1qbsDMPGag-Pol polyprotein3.4.23.160.470
3bxrDRRGag-Pol polyprotein3.4.23.160.470
4dqb017Gag-Pol polyprotein/0.470
1npvL27Gag-Pol polyprotein3.4.23.160.469
3nu6478Gag-Pol polyprotein3.4.23.160.469
1t7j478Gag-Pol polyprotein3.4.23.160.468
4j54G52Gag-Pol polyprotein3.4.23.160.468
3nuj478Gag-Pol polyprotein3.4.23.160.467
3el01UNGag-Pol polyprotein3.4.23.160.466
3o99K13Pol polyprotein/0.466
1k6pXN3Gag-Pol polyprotein3.4.23.160.464
1qbt146Gag-Pol polyprotein3.4.23.160.464
2pym1UNGag-Pol polyprotein3.4.23.160.463
3ec0GRLGag-Pol polyprotein3.4.23.470.463
1bwb146Gag-Pol polyprotein3.4.23.160.462
1k6cMK1Gag-Pol polyprotein3.4.23.160.462
4dqf017Gag-Pol polyprotein/0.462
2q55MU0Protease/0.461
2r3tG4GGag-Pol polyprotein3.4.23.160.461
3wsjMK1Protease/0.460
1k2c0Q4Gag-Pol polyprotein3.4.23.160.459
2pwcG3GGag-Pol polyprotein3.4.23.160.459
1bv9XV6Gag-Pol polyprotein3.4.23.160.458
1hpv478Gag-Pol polyprotein/0.458
2hs1017Protease/0.458
3nu3478Gag-Pol polyprotein3.4.23.160.458
3ogqAB1Pol polyprotein/0.458
2psvMUVProtease/0.457
2q631UNGag-Pol polyprotein3.4.23.160.453
1metDMPGag-Pol polyprotein3.4.23.160.452
3lzv017Gag-Pol polyprotein3.4.23.160.452
4q1x017Gag-Pol polyprotein3.4.23.160.451
1k6tXN1Gag-Pol polyprotein3.4.23.160.450
2i0dMUTProtease/0.450
1mrxK57Gag-Pol polyprotein3.4.23.160.448
3qpjN4IGag-Pol polyprotein3.4.23.160.446
5upjUINGag-Pol polyprotein/0.442
3ecg065Gag-Pol polyprotein3.4.23.470.440