Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a4o664Serine/threonine-protein kinase PLK12.7.11.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a4o664Serine/threonine-protein kinase PLK12.7.11.211.000
2yac937Serine/threonine-protein kinase PLK12.7.11.210.600
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.550
2owb626Serine/threonine-protein kinase PLK12.7.11.210.540
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.513
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.503
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.489
2in6839Wee1-like protein kinase2.7.10.20.482
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.482
2z2w770Wee1-like protein kinase2.7.10.20.480
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.479
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.476
3d5wADPSerine/threonine-protein kinase PLK/0.474
2io6330Wee1-like protein kinase2.7.10.20.472
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.471
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.465
3biz61EWee1-like protein kinase2.7.10.20.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4b2gV1NUncharacterized protein/0.442
1x8b824Wee1-like protein kinase2.7.10.20.441
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.441
4jbtASDCytochrome P450 monooxygenase/0.441
4f0fACPProbable serine/threonine-protein kinase roco42.7.11.10.440