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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.11.000
3gw9VNILanosterol 14-alpha-demethylase/0.474
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4g3jVNTLanosterol 14-alpha-demethylase/0.465
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.463
2om9AJAPeroxisome proliferator-activated receptor gamma/0.461
3t2kFADSulfide-quinone reductase/0.461
3t14FADSulfide-quinone reductase/0.460
3h0aD30Peroxisome proliferator-activated receptor gamma/0.458
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.452
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.449
3sz0FADSulfide-quinone reductase/0.449
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3i99FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.447
4xgiNADGlutamate dehydrogenase/0.447
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.446
3oc4FADOxidoreductase, pyridine nucleotide-disulfide family/0.446
3s3r0IWCathepsin B-like peptidase (C01 family)/0.446
2i4xKGQProtease/0.445
4b7xNAPProbable oxidoreductase/0.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4njsG08Protease/0.445
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.444
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.444
3t2yFADSulfide-quinone reductase/0.444
1yb5NAPQuinone oxidoreductase1.6.5.50.443
1iyzNDPProbable quinone oxidoreductase/0.442
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.442
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
2ignFADPyranose 2-oxidase/0.441
2y0mACOHistone acetyltransferase KAT8/0.441
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
3t2zFADSulfide-quinone reductase/0.440