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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.607
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.600
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.570
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
1qmzATPCyclin-dependent kinase 22.7.11.220.511
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.501
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
4qnyANPMitogen activated protein kinase, putative/0.487
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.473
5bylGCPBifunctional AAC/APH2.3.10.473
4ysjADPCalmodulin-like domain protein kinase/0.470
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2cjmATPCyclin-dependent kinase 22.7.11.220.464
5eg3ACPFibroblast growth factor receptor 2/0.462
1ig1ANPDeath-associated protein kinase 12.7.11.10.459
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.459
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
5iqiGNPBifunctional AAC/APH2.3.10.452
5iqhGNPBifunctional AAC/APH2.3.10.449
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4deeADPAurora kinase A2.7.11.10.445
4i3zADPCyclin-dependent kinase 22.7.11.220.445
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3tqhNDPQuinone oxidoreductase/0.442
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442