Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3wwm | ADP | [LysW]-aminoadipate kinase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3wwm | ADP | [LysW]-aminoadipate kinase | / | 1.000 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.522 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.499 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.496 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.495 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.490 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.490 | |
| 3u9e | COA | Lmo1369 protein | / | 0.489 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.488 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.488 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.488 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.487 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.487 | |
| 2pja | 33Z | Carboxypeptidase B | / | 0.487 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.486 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.486 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.484 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.484 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.483 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.482 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.482 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.481 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.480 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.479 | |
| 3wag | TYD | Glycosyltransferase | / | 0.479 | |
| 4lut | DCS | Alanine racemase | / | 0.479 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.478 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.478 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.478 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.478 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.477 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.477 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.475 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.474 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.474 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.474 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.474 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.473 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.472 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.472 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.471 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.471 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.470 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.470 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.470 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.470 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.469 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.469 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.469 | |
| 1icv | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.468 | |
| 1kqc | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.468 | |
| 3eks | CY9 | Actin-5C | / | 0.468 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.468 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.468 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.468 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.467 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.467 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.467 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.467 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.467 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.466 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.466 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.466 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.466 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.466 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.465 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.465 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.465 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.465 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.465 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.465 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.464 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.464 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.464 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.464 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.464 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.463 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.463 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.463 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.463 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.463 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.462 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.462 | |
| 3a3g | DLZ | Lumazine protein | / | 0.462 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.462 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.462 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.461 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.461 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.461 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.461 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.461 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.461 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.461 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.461 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.460 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.460 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.460 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.460 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.460 | |
| 1oon | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.459 | |
| 1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.459 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.459 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.459 | |
| 2q0k | NAP | Thioredoxin reductase | 1.8.1.9 | 0.459 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.459 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.459 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.459 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.459 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 5aga | ANP | DNA polymerase theta | / | 0.459 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.458 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.458 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.458 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.457 | |
| 1hzj | UD1 | UDP-glucose 4-epimerase | / | 0.457 | |
| 1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.457 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.457 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.457 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.457 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.457 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.457 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.457 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.456 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.456 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.456 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.456 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.456 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.456 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.456 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.456 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.456 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.455 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.455 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.455 | |
| 1p4a | PCP | Pur operon repressor | / | 0.455 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.455 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.455 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.455 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.455 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.455 | |
| 4yqf | GDP | Septin-9 | / | 0.455 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.454 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.454 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.454 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.454 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.454 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.454 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.454 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.454 | |
| 3l5b | BDO | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.454 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.454 | |
| 4ttc | FMN | Iodotyrosine deiodinase 1 | / | 0.454 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.453 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.453 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.453 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.453 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 2x3j | ATP | AcsD | / | 0.453 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 3lcj | COA | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.453 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.453 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.453 | |
| 3v2u | ATP | Protein GAL3 | / | 0.453 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4dja | FAD | (6-4) photolyase | / | 0.453 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.453 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.453 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.453 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.453 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.452 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.452 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.452 | |
| 2w02 | ATP | AcsD | / | 0.452 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.452 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.452 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.452 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.452 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.451 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.451 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3d3x | ARG_ILE_MET_GLU_NH2 | Type E botulinum toxin | / | 0.451 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.451 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.451 | |
| 4ke0 | 1R8 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.450 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.450 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.450 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 3a5y | KAA | Elongation factor P--(R)-beta-lysine ligase | / | 0.450 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.450 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.450 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.450 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.450 | |
| 4rph | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.450 | |
| 4u0z | APC | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.450 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.450 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.449 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.449 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.449 | |
| 2r59 | PH0 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.449 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.449 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.449 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.449 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.449 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4z54 | GDP | Neuronal-specific septin-3 | / | 0.449 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.449 | |
| 5cfp | C2E | Stimulator of interferon genes protein | / | 0.449 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.448 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.448 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.448 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.448 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.448 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4blr | UTP | NTPase P4 | / | 0.448 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.448 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4j7g | TRH | PCZA361.3 | / | 0.448 | |
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 1ds7 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.447 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.447 | |
| 2eld | SAH | Diphthine synthase | / | 0.447 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.447 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.447 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.447 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.447 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4h4u | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.447 | |
| 4hyv | PEP | Pyruvate kinase 1 | 2.7.1.40 | 0.447 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.447 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.447 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 5cfl | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.447 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.446 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.446 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.446 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.446 | |
| 1zp3 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.446 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.446 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.446 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.446 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 3dj4 | UD1 | Bifunctional protein GlmU | / | 0.446 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.446 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.446 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.446 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.446 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.446 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.446 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.446 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.446 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.445 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.445 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.445 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.445 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.445 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.445 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.445 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.445 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.445 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.445 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4j7h | TRH | PCZA361.3 | / | 0.445 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.445 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.445 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.445 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.444 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.444 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.444 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.444 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.444 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.444 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.444 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4b00 | I6X | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.444 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4ha9 | NDP | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase | 1.1.1.302 | 0.444 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4kc4 | WS3 | Histo-blood group ABO system transferase | / | 0.444 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.444 | |
| 4lrl | TTP | HD domain protein | / | 0.444 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.444 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.443 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.443 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.443 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.443 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.443 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.443 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.443 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.443 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.443 | |
| 3qdl | FMN | Oxygen-insensitive NADPH nitroreductase | / | 0.443 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.443 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.443 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.443 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4e2w | JHZ | Methyltransferase | / | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.443 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.442 | |
| 1i5z | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.442 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.442 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.442 | |
| 3iaa | TYD | CalG2 | / | 0.442 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.442 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.442 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.442 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.442 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.441 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.441 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.441 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.441 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 3ieu | GDP | GTPase Era | / | 0.441 | |
| 3nbv | ANP | Ketohexokinase | / | 0.441 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.441 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.441 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.441 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.441 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 4xr9 | NAD | CalS8 | / | 0.441 | |
| 5e7o | MGD | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.441 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.440 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 1gm9 | SOX | Penicillin G acylase | 3.5.1.11 | 0.440 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.440 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.440 | |
| 2hux | SAH | Diphthine synthase | / | 0.440 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.440 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.440 | |
| 3hdq | GDU | UDP-galactopyranose mutase | / | 0.440 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3m4p | 4AD | Asparaginyl-tRNA synthetase, putative | / | 0.440 | |
| 3rk1 | ATP | N-type ATP pyrophosphatase superfamily | / | 0.440 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.440 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.440 | |
| 3x21 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.440 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.440 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.440 |