sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.918 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.846 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.843 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.810 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.696 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.693 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.692 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.687 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.666 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.620 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.596 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.593 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.525 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.505 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.500 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.494 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.482 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.482 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.482 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.479 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.476 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.469 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.465 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.463 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.461 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.461 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.460 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 2y3r | TRK | TamL | / | 0.458 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.458 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.456 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.455 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.455 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2y4g | TIR | TamL | / | 0.451 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2y3s | TIR | TamL | / | 0.449 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.448 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.448 | |
| 3eej | 53R | Uncharacterized protein | / | 0.447 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.444 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.444 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.443 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.441 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.440 | |
| 3eem | 53V | Uncharacterized protein | / | 0.440 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.440 |