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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3wowANPCasein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3wowANPCasein kinase II subunit alpha2.7.11.11.000
3q9xEMOCasein kinase II subunit alpha2.7.11.10.545
3at4CCKCasein kinase II subunit alpha2.7.11.10.543
3be9P04Casein kinase II subunit alpha2.7.11.10.542
5cvfATPCasein kinase II subunit alpha2.7.11.10.529
4grb0XGCasein kinase II subunit alpha2.7.11.10.528
1dawANPCasein kinase II subunit alpha2.7.11.10.521
4jr7GNPCasein kinase II subunit alpha2.7.11.10.520
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.518
5cshATPCasein kinase II subunit alpha2.7.11.10.518
5cvhADPCasein kinase II subunit alpha2.7.11.10.517
3nga3NGCasein kinase II subunit alpha2.7.11.10.514
1pjkANPCasein kinase II subunit alpha2.7.11.10.507
2pvlP55Casein kinase II subunit alpha2.7.11.10.505
2pvhP19Casein kinase II subunit alpha2.7.11.10.504
4lfiGNPCasein kinase II subunit alpha2.7.11.10.503
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.502
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.501
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.499
1dayGNPCasein kinase II subunit alpha2.7.11.10.498
3nszANPCasein kinase II subunit alpha2.7.11.10.498
4ez50RSCyclin-dependent kinase 62.7.11.220.494
2pvnP63Casein kinase II subunit alpha2.7.11.10.493
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.492
4ix5ANPUncharacterized protein/0.491
3u4uLNHCasein kinase II subunit alpha2.7.11.10.489
4gub0Y4Casein kinase II subunit alpha2.7.11.10.489
5cu6ATPCasein kinase II subunit alpha2.7.11.10.484
4qmlANPSerine/threonine-protein kinase 242.7.11.10.483
1lp4ANPCasein kinase II subunit alpha2.7.11.10.482
3at3ATKCasein kinase II subunit alpha2.7.11.10.482
4anmWULCasein kinase II subunit alpha2.7.11.10.482
4dgnLU2Casein kinase II subunit alpha2.7.11.10.481
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.480
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.476
4dgo0JWCasein kinase II subunit alpha2.7.11.10.476
4jia1K3Tyrosine-protein kinase JAK2/0.474
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.469
4ii5ADPCyclin-dependent kinase 22.7.11.220.469
4k33ACPFibroblast growth factor receptor 32.7.10.10.468
3owk18ECasein kinase II subunit alpha2.7.11.10.467
3zxtACPDeath-associated protein kinase 12.7.11.10.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.466
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
3axwTIDCasein kinase II subunit alpha2.7.11.10.466
4jqeANPCasein kinase II subunit alpha2.7.11.10.466
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.465
1om1IQACasein kinase II subunit alpha2.7.11.10.464
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.464
4aguD15Cyclin-dependent kinase-like 1/0.464
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.463
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.462
2henADPEphrin type-B receptor 22.7.10.10.461
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.460
2pywADPMethylthioribose kinase2.7.1.1000.459
3pe2E1BCasein kinase II subunit alpha2.7.11.10.459
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.459
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.458
1qmzATPCyclin-dependent kinase 22.7.11.220.457
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.456
4y0xADPSerine/threonine-protein kinase PknG2.7.11.10.456
2izrBRKCasein kinase I isoform gamma-32.7.11.10.455
3mb714ICasein kinase II subunit alpha2.7.11.10.455
5cnnANPEpidermal growth factor receptor2.7.10.10.455
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4bcmT7ZCyclin-dependent kinase 22.7.11.220.453
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.452
1zrzBI1Protein kinase C iota type2.7.11.130.451
4dgmAGICasein kinase II subunit alpha2.7.11.10.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
4bbe3O4Tyrosine-protein kinase JAK2/0.450
4j95ACPFibroblast growth factor receptor 2/0.450
1ir3ANPInsulin receptor2.7.10.10.449
2fvdLIACyclin-dependent kinase 22.7.11.220.449
3rak03ZCyclin-dependent kinase 22.7.11.220.449
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.449
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.449
4ix6ADPUncharacterized protein/0.448
2w05FRTCyclin-dependent kinase 22.7.11.220.447
2w17I19Cyclin-dependent kinase 22.7.11.220.447
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.446
3sw719KCyclin-dependent kinase 22.7.11.220.445
4riyADPEpidermal growth factor receptor2.7.10.10.445
1hquHBYGag-Pol polyprotein2.7.7.490.444
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
2zjwREFCasein kinase II subunit alpha2.7.11.10.444
3lpbNVBTyrosine-protein kinase JAK2/0.444
3vrwYS5Vitamin D3 receptor/0.444
4ki8ADP60 kDa chaperonin/0.444
5awmANPStress-activated protein kinase JNK2.7.11.240.444
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.443
2etm7PYFocal adhesion kinase 12.7.10.20.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.443
4xlvACPInsulin receptor2.7.10.10.443
5kgpACOPredicted acetyltransferase/0.443
2hcdBIVVitamin D3 receptor A/0.442
2py3ACPFibroblast growth factor receptor 2/0.442
3ormAGSSerine/threonine protein kinase/0.442
4c4iX20Dual specificity protein kinase TTK2.7.12.10.442
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.441
5kghACOPredicted acetyltransferase/0.441
1i44ACPInsulin receptor2.7.10.10.440
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440
3icsCOACoenzyme A disulfide reductase/0.440
3s1h56ZCyclin-dependent kinase 22.7.11.220.440
3uli1N3Cyclin-dependent kinase 22.7.11.220.440