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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3wleNAD(R)-specific carbonyl reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3wleNAD(R)-specific carbonyl reductase/1.000
4c4oNADSADH/0.626
3jv7NADSecondary alcohol dehydrogenase/0.533
2xaaNADSecondary alcohol dehydrogenase/0.518
1h2bNAJNAD-dependent alcohol dehydrogenase/0.463
5kj6NAJAlcohol dehydrogenase E chain1.1.1.10.452
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.445
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.444
3cosNADAlcohol dehydrogenase 41.1.1.10.442
4rquNADAlcohol dehydrogenase class-P/0.440