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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3wdsNADNADH-dependent quinuclidinone reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3wdsNADNADH-dependent quinuclidinone reductase/1.000
3ak4NADNADH-dependent quinuclidinone reductase/0.606
4gh5NADShort-chain dehydrogenase/reductase SDR/0.585
5jlaNADPutative short-chain dehydrogenase/reductase/0.541
4fn4NADShort chain dehydrogenase/0.535
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.531
2dteNAIGlucose 1-dehydrogenase related protein/0.530
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.521
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.521
4nbwNADShort-chain dehydrogenase/reductase SDR/0.514
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.513
2wsbNADGalactitol dehydrogenase/0.512
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.511
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.510
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.509
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.509
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.502
5lc1NADL-threonine 3-dehydrogenase/0.501
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.500
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.500
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.500
3w8eNAD3-hydroxybutyrate dehydrogenase/0.497
1iy8NADLevodione reductase/0.496
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.495
1zemNADXylitol dehydrogenase/0.494
4yaiNAIC alpha-dehydrogenase/0.494
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.493
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.493
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.491
3rj5NADAlcohol dehydrogenase1.1.1.10.491
3rj9NADAlcohol dehydrogenase1.1.1.10.491
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.490
3sjuNDPKeto reductase/0.490
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.489
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.488
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.488
4j7xNAPSepiapterin reductase1.1.1.1530.485
3p19NDPPutative blue fluorescent protein/0.484
4yagNAIC alpha-dehydrogenase/0.484
1b16NAQAlcohol dehydrogenase1.1.1.10.483
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.483
1ipeNDPTropinone reductase 21.1.1.2360.483
1b15NAEAlcohol dehydrogenase1.1.1.10.482
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.482
4j7uNAPSepiapterin reductase1.1.1.1530.482
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.481
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.481
3sx2NADUncharacterized protein/0.481
3s55NADPutative short-chain dehydrogenase/reductase/0.480
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.480
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.479
2yy7NADL-threonine dehydrogenase/0.479
3uxyNADShort-chain dehydrogenase/reductase SDR/0.478
1x7hNDPPutative ketoacyl reductase1.3.10.477
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.477
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.477
3qrwNDPPutative ketoacyl reductase1.3.10.477
5jydNADShort chain dehydrogenase/0.476
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.475
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.475
1oaaNAPSepiapterin reductase1.1.1.1530.474
3d3wNAPL-xylulose reductase1.1.1.100.474
3lqfNADGalactitol dehydrogenase/0.474
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.473
1pr9NAPL-xylulose reductase1.1.1.100.473
3a1nNADNDP-sugar epimerase/0.473
1ae1NAPTropinone reductase 1/0.472
2yutNAPPutative short-chain oxidoreductase/0.472
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.472
3a4vNADNDP-sugar epimerase/0.472
5jy1NADPutative short-chain dehydrogenase/reductase/0.472
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.471
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
4hwkNAPSepiapterin reductase1.1.1.1530.471
1mg5NAIAlcohol dehydrogenase1.1.1.10.470
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.470
1n5dNDPCarbonyl reductase [NADPH] 1/0.469
1rwbNADGlucose 1-dehydrogenase1.1.1.470.469
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.469
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.469
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.468
4dc1NDPPutative ketoacyl reductase1.3.10.467
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.467
2wdzNADGalactitol dehydrogenase/0.466
1snyNAPLD36273p/0.465
1wntNAPL-xylulose reductase1.1.1.100.465
5idwNAPShort-chain dehydrogenase/reductase SDR/0.465
1geeNADGlucose 1-dehydrogenase1.1.1.470.464
1sbyNADAlcohol dehydrogenase1.1.1.10.463
3ggpNADPrephenate dehydrogenase/0.463
1xg5NAPDehydrogenase/reductase SDR family member 11/0.461
3gy0NAPNAD(P)-dependent oxidoreductase/0.459
3ai2NDPNADPH-sorbose reductase/0.458
3toxNAPPutative oxidoreductase/0.458
3vdqNAD3-hydroxybutyrate dehydrogenase/0.458
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.458
2bd0NAPSepiapterin reductase/0.457
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.457
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.457
3l77NJPShort-chain alcohol dehydrogenase/0.457
3w8fNAD3-hydroxybutyrate dehydrogenase/0.457
1w4zNAPPutative ketoacyl reductase1.3.10.456
1x7gNAPPutative ketoacyl reductase1.3.10.455
2jahNDPClavaldehyde dehydrogenase/0.455
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.454
1gcoNADGlucose 1-dehydrogenase1.1.1.470.451
3w8dNAD3-hydroxybutyrate dehydrogenase/0.451
4qecNAPElxO/0.448
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.446
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.445
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
3tscNADUncharacterized protein/0.443
4b79NADProbable short-chain dehydrogenase/0.443
1b14NADAlcohol dehydrogenase1.1.1.10.442
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.442
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.442
3ajrNADNDP-sugar epimerase/0.441
4bmvNAPShort-chain dehydrogenase/0.441
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.441
4idgNADPutative UDP-glucose 4-epimerase/0.441
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1g6kNADGlucose 1-dehydrogenase1.1.1.470.440
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.440