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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3wblPDYCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3wblPDYCyclin-dependent kinase 22.7.11.221.000
2uznC96Cyclin-dependent kinase 22.7.11.220.585
1y91CT9Cyclin-dependent kinase 22.7.11.220.584
3rmf20ZCyclin-dependent kinase 22.7.11.220.553
2c6o4SPCyclin-dependent kinase 22.7.11.220.550
2bhhRYUCyclin-dependent kinase 22.7.11.220.549
3rk708ZCyclin-dependent kinase 22.7.11.220.549
3lfqA28Cyclin-dependent kinase 22.7.11.220.548
3rm719ZCyclin-dependent kinase 22.7.11.220.542
1oirHDYCyclin-dependent kinase 22.7.11.220.536
2w06FRVCyclin-dependent kinase 22.7.11.220.536
2r3lSCWCyclin-dependent kinase 22.7.11.220.535
3rk507ZCyclin-dependent kinase 22.7.11.220.534
3s2pPMUCyclin-dependent kinase 22.7.11.220.530
3rkb12ZCyclin-dependent kinase 22.7.11.220.529
1p2a5BNCyclin-dependent kinase 22.7.11.220.528
2uzoC62Cyclin-dependent kinase 22.7.11.220.527
3ezvEZVCyclin-dependent kinase 22.7.11.220.526
3uli1N3Cyclin-dependent kinase 22.7.11.220.525
4fkj11KCyclin-dependent kinase 22.7.11.220.525
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.524
3lfnA27Cyclin-dependent kinase 22.7.11.220.524
1g5sI17Cyclin-dependent kinase 22.7.11.220.523
3s1h56ZCyclin-dependent kinase 22.7.11.220.523
3r8lZ30Cyclin-dependent kinase 22.7.11.220.522
3rni21ZCyclin-dependent kinase 22.7.11.220.522
4bgh3I6Cyclin-dependent kinase 22.7.11.220.522
1ykr628Cyclin-dependent kinase 22.7.11.220.521
3sw418KCyclin-dependent kinase 22.7.11.220.520
1gih1PUCyclin-dependent kinase 22.7.11.220.519
3qzgX67Cyclin-dependent kinase 22.7.11.220.517
3sw719KCyclin-dependent kinase 22.7.11.220.517
1pxmCK5Cyclin-dependent kinase 22.7.11.220.516
3qtwX3ACyclin-dependent kinase 22.7.11.220.515
3ig7EFPCyclin-dependent kinase 22.7.11.220.513
3iggEFQCyclin-dependent kinase 22.7.11.220.512
3lfsA07Cyclin-dependent kinase 22.7.11.220.511
1aq1STUCyclin-dependent kinase 22.7.11.220.510
3qxoX65Cyclin-dependent kinase 22.7.11.220.510
3rk909ZCyclin-dependent kinase 22.7.11.220.510
4fkv61KCyclin-dependent kinase 22.7.11.220.510
1pxlCK4Cyclin-dependent kinase 22.7.11.220.509
4fkr45KCyclin-dependent kinase 22.7.11.220.509
1ke7LS3Cyclin-dependent kinase 22.7.11.220.508
3qtqX35Cyclin-dependent kinase 22.7.11.220.508
2r3kSCQCyclin-dependent kinase 22.7.11.220.507
1fvt106Cyclin-dependent kinase 22.7.11.220.506
3qtuX44Cyclin-dependent kinase 22.7.11.220.506
3r6xX84Cyclin-dependent kinase 22.7.11.220.506
3rjc06ZCyclin-dependent kinase 22.7.11.220.504
4acm7YGCyclin-dependent kinase 22.7.11.220.504
1pxpCK8Cyclin-dependent kinase 22.7.11.220.503
2bheBRYCyclin-dependent kinase 22.7.11.220.503
3qqfX07Cyclin-dependent kinase 22.7.11.220.503
2vv9IM9Cyclin-dependent kinase 22.7.11.220.502
1gii1PUCyclin-dependent kinase 22.7.11.220.501
2w1hL0FCyclin-dependent kinase 22.7.11.220.501
3r73X87Cyclin-dependent kinase 22.7.11.220.500
1pxkCK3Cyclin-dependent kinase 22.7.11.220.498
1w0xOLOCyclin-dependent kinase 22.7.11.220.498
2b53D23Cyclin-dependent kinase 22.7.11.220.497
4fkg4CKCyclin-dependent kinase 22.7.11.220.497
3qtxX43Cyclin-dependent kinase 22.7.11.220.496
3rahO1ZCyclin-dependent kinase 22.7.11.220.496
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.495
3rpy27ZCyclin-dependent kinase 22.7.11.220.495
1ke6LS2Cyclin-dependent kinase 22.7.11.220.494
1oitHDTCyclin-dependent kinase 22.7.11.220.494
3ggfGVDSerine/threonine-protein kinase 26/0.493
3qxpX64Cyclin-dependent kinase 22.7.11.220.493
3r9hZ67Cyclin-dependent kinase 22.7.11.220.493
3roy22ZCyclin-dependent kinase 22.7.11.220.493
4erwSTUCyclin-dependent kinase 22.7.11.220.493
2pvnP63Casein kinase II subunit alpha2.7.11.10.492
3le62BZCyclin-dependent kinase 22.7.11.220.492
3r83Z14Cyclin-dependent kinase 22.7.11.220.492
3s0o50ZCyclin-dependent kinase 22.7.11.220.492
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.491
2xmyCDKCyclin-dependent kinase 22.7.11.220.491
3rpo24ZCyclin-dependent kinase 22.7.11.220.491
1v1k3FPCyclin-dependent kinase 22.7.11.220.490
2j9mPY8Cyclin-dependent kinase 22.7.11.220.490
2uzdC85Cyclin-dependent kinase 22.7.11.220.490
2vttLZDCyclin-dependent kinase 22.7.11.220.490
3qtrX36Cyclin-dependent kinase 22.7.11.220.490
3r9nZ68Cyclin-dependent kinase 22.7.11.220.490
3ral04ZCyclin-dependent kinase 22.7.11.220.490
4fkq42KCyclin-dependent kinase 22.7.11.220.488
4fkw62KCyclin-dependent kinase 22.7.11.220.487
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.486
2vu3LZECyclin-dependent kinase 22.7.11.220.484
3rak03ZCyclin-dependent kinase 22.7.11.220.484
2a4lRRCCyclin-dependent kinase 22.7.11.220.483
3fz1B98Cyclin-dependent kinase 22.7.11.220.483
4ek816KCyclin-dependent kinase 22.7.11.220.483
4fko20KCyclin-dependent kinase 22.7.11.220.483
2i40BLZCyclin-dependent kinase 22.7.11.220.482
3qzhX69Cyclin-dependent kinase 22.7.11.220.482
3r7yZ04Cyclin-dependent kinase 22.7.11.220.482
3ti1B49Cyclin-dependent kinase 22.7.11.220.482
1di8DTQCyclin-dependent kinase 22.7.11.220.481
4qmpDKISerine/threonine-protein kinase 242.7.11.10.480
1pyePM1Cyclin-dependent kinase 22.7.11.220.478
3qqhX0ACyclin-dependent kinase 22.7.11.220.478
3qqlX03Cyclin-dependent kinase 22.7.11.220.478
2r3fSC8Cyclin-dependent kinase 22.7.11.220.477
1h1s4SPCyclin-dependent kinase 22.7.11.220.476
2btrU73Cyclin-dependent kinase 22.7.11.220.476
3r7iX9ICyclin-dependent kinase 22.7.11.220.476
1pkdUCNCyclin-dependent kinase 22.7.11.220.475
2w17I19Cyclin-dependent kinase 22.7.11.220.475
3qqkX02Cyclin-dependent kinase 22.7.11.220.475
3raiX85Cyclin-dependent kinase 22.7.11.220.475
2c5nCK8Cyclin-dependent kinase 22.7.11.220.474
2c6lDT4Cyclin-dependent kinase 22.7.11.220.474
2uzlC94Cyclin-dependent kinase 22.7.11.220.474
2vtsLZCCyclin-dependent kinase 22.7.11.220.474
3my5RFZCyclin-dependent kinase 22.7.11.220.474
3r28XA0Cyclin-dependent kinase 22.7.11.220.474
1ke5LS1Cyclin-dependent kinase 22.7.11.220.473
2a0cCK9Cyclin-dependent kinase 22.7.11.220.473
3ql8X01Cyclin-dependent kinase 22.7.11.220.473
1fvv107Cyclin-dependent kinase 22.7.11.220.472
1ke9LS5Cyclin-dependent kinase 22.7.11.220.472
2wpa889Cyclin-dependent kinase 22.7.11.220.472
1w8cN69Cyclin-dependent kinase 22.7.11.220.471
2c5yMTWCyclin-dependent kinase 22.7.11.220.471
2wxvWXVCyclin-dependent kinase 22.7.11.220.471
4eor4SPCyclin-dependent kinase 22.7.11.220.471
3qu0X40Cyclin-dependent kinase 22.7.11.220.470
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.469
1oguST8Cyclin-dependent kinase 22.7.11.220.468
3r1sX73Cyclin-dependent kinase 22.7.11.220.468
2r3o2SCCyclin-dependent kinase 22.7.11.220.467
3r1qX75Cyclin-dependent kinase 22.7.11.220.467
4fx360KCyclin-dependent kinase 22.7.11.220.467
1urwI1PCyclin-dependent kinase 22.7.11.220.466
4kd11QKCyclin-dependent kinase 22.7.11.220.466
1dm2HMDCyclin-dependent kinase 22.7.11.220.464
2r3r6SCCyclin-dependent kinase 22.7.11.220.464
2vthLZ2Cyclin-dependent kinase 22.7.11.220.464
4ek610KCyclin-dependent kinase 22.7.11.220.464
2c69CT8Cyclin-dependent kinase 22.7.11.220.463
2c6tDT5Cyclin-dependent kinase 22.7.11.220.463
2xikJ60Serine/threonine-protein kinase 252.7.11.10.463
3r8pZ46Cyclin-dependent kinase 22.7.11.220.463
3ddpRC8Cyclin-dependent kinase 22.7.11.220.462
3qzfX66Cyclin-dependent kinase 22.7.11.220.462
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.462
2duv371Cyclin-dependent kinase 22.7.11.220.461
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.461
2xnbY8LCyclin-dependent kinase 22.7.11.220.461
3r9oZ71Cyclin-dependent kinase 22.7.11.220.461
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.461
2b55D31Cyclin-dependent kinase 22.7.11.220.460
2r3p3SCCyclin-dependent kinase 22.7.11.220.460
3r7uX96Cyclin-dependent kinase 22.7.11.220.460
2btsU32Cyclin-dependent kinase 22.7.11.220.459
3r8zZ63Cyclin-dependent kinase 22.7.11.220.459
2r64740Cyclin-dependent kinase 22.7.11.220.458
3dogNNNCyclin-dependent kinase 22.7.11.220.458
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.458
1pxoCK7Cyclin-dependent kinase 22.7.11.220.457
2b7aIZATyrosine-protein kinase JAK2/0.457
3r8vZ62Cyclin-dependent kinase 22.7.11.220.457
3tnwF18Cyclin-dependent kinase 22.7.11.220.457
3be9P04Casein kinase II subunit alpha2.7.11.10.456
3qx2X63Cyclin-dependent kinase 22.7.11.220.456
4fkpLS5Cyclin-dependent kinase 22.7.11.220.456
4fks46KCyclin-dependent kinase 22.7.11.220.456
1ckpPVBCyclin-dependent kinase 22.7.11.220.455
2c6iDT1Cyclin-dependent kinase 22.7.11.220.455
3qwjX6ACyclin-dependent kinase 22.7.11.220.455
1oiyN41Cyclin-dependent kinase 22.7.11.220.454
2b52D42Cyclin-dependent kinase 22.7.11.220.454
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3rpv26ZCyclin-dependent kinase 22.7.11.220.454
3sqq99ZCyclin-dependent kinase 22.7.11.220.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.453
3qtsX46Cyclin-dependent kinase 22.7.11.220.453
3sheI85MAP kinase-activated protein kinase 32.7.11.10.453
3i60E86Mitogen-activated protein kinase 12.7.11.240.452
3r9dX6BCyclin-dependent kinase 22.7.11.220.452
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.452
2b54D05Cyclin-dependent kinase 22.7.11.220.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
3qziX72Cyclin-dependent kinase 22.7.11.220.451
4qmySTUSerine/threonine-protein kinase 242.7.11.10.451
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.450
3qwkX62Cyclin-dependent kinase 22.7.11.220.450
3unk0BYCyclin-dependent kinase 22.7.11.220.450
1gij2PUCyclin-dependent kinase 22.7.11.220.449
3qtzX42Cyclin-dependent kinase 22.7.11.220.449
4fkt48KCyclin-dependent kinase 22.7.11.220.449
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.448
3rpr25ZCyclin-dependent kinase 22.7.11.220.448
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.448
1h1r6CPCyclin-dependent kinase 22.7.11.220.447
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
4lyn1YGCyclin-dependent kinase 22.7.11.220.447
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.447
2fxdDR7Pol polyprotein/0.446
2r3jSCJCyclin-dependent kinase 22.7.11.220.446
4ivb1J5Tyrosine-protein kinase JAK1/0.446
1finATPCyclin-dependent kinase 22.7.11.220.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.445
1r78FMDCyclin-dependent kinase 22.7.11.220.445
1vyzN5BCyclin-dependent kinase 22.7.11.220.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
3qx4X4BCyclin-dependent kinase 22.7.11.220.444
3rm618ZCyclin-dependent kinase 22.7.11.220.444
4bcpT3CCyclin-dependent kinase 22.7.11.220.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
2c6kDT2Cyclin-dependent kinase 22.7.11.220.443
2r3q5SCCyclin-dependent kinase 22.7.11.220.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
2r3iSCFCyclin-dependent kinase 22.7.11.220.442
3r7vZ02Cyclin-dependent kinase 22.7.11.220.442
3r8uZ31Cyclin-dependent kinase 22.7.11.220.442
3tiz3TICyclin-dependent kinase 22.7.11.220.442
4btjADPTau-tubulin kinase 12.7.11.10.442
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
2wihP48Cyclin-dependent kinase 22.7.11.220.441
3efwAK8Aurora kinase A2.7.11.10.441
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.441
1y8yCT7Cyclin-dependent kinase 22.7.11.220.440
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.440
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.440
3s00Z60Cyclin-dependent kinase 22.7.11.220.440
5dr9SKEAurora kinase A2.7.11.10.440