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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w8eNAD3-hydroxybutyrate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w8eNAD3-hydroxybutyrate dehydrogenase/1.000
3vdqNAD3-hydroxybutyrate dehydrogenase/0.687
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.632
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.625
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.621
3w8fNAD3-hydroxybutyrate dehydrogenase/0.619
3w8dNAD3-hydroxybutyrate dehydrogenase/0.609
3toxNAPPutative oxidoreductase/0.605
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.568
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.566
3ai2NDPNADPH-sorbose reductase/0.562
4b79NADProbable short-chain dehydrogenase/0.553
4j7xNAPSepiapterin reductase1.1.1.1530.549
1xg5NAPDehydrogenase/reductase SDR family member 11/0.540
1x7hNDPPutative ketoacyl reductase1.3.10.538
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.538
5jlaNADPutative short-chain dehydrogenase/reductase/0.538
4bmvNAPShort-chain dehydrogenase/0.534
5idwNAPShort-chain dehydrogenase/reductase SDR/0.534
2wdzNADGalactitol dehydrogenase/0.532
4j7uNAPSepiapterin reductase1.1.1.1530.532
2dteNAIGlucose 1-dehydrogenase related protein/0.530
1geeNADGlucose 1-dehydrogenase1.1.1.470.529
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.529
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.526
1ipeNDPTropinone reductase 21.1.1.2360.525
1rwbNADGlucose 1-dehydrogenase1.1.1.470.524
2wsbNADGalactitol dehydrogenase/0.524
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.524
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.524
1x7gNAPPutative ketoacyl reductase1.3.10.523
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.523
1w4zNAPPutative ketoacyl reductase1.3.10.522
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.520
1oaaNAPSepiapterin reductase1.1.1.1530.520
1pr9NAPL-xylulose reductase1.1.1.100.520
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.520
1xkqNDPUncharacterized protein/0.519
2jahNDPClavaldehyde dehydrogenase/0.517
4yaiNAIC alpha-dehydrogenase/0.516
1g6kNADGlucose 1-dehydrogenase1.1.1.470.515
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.515
1gcoNADGlucose 1-dehydrogenase1.1.1.470.514
1iy8NADLevodione reductase/0.512
2yutNAPPutative short-chain oxidoreductase/0.512
3wdsNADNADH-dependent quinuclidinone reductase/0.512
1n5dNDPCarbonyl reductase [NADPH] 1/0.511
4hwkNAPSepiapterin reductase1.1.1.1530.509
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.508
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.506
3sjuNDPKeto reductase/0.506
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.505
3p19NDPPutative blue fluorescent protein/0.503
3qrwNDPPutative ketoacyl reductase1.3.10.503
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.503
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.503
1ae1NAPTropinone reductase 1/0.501
3gy0NAPNAD(P)-dependent oxidoreductase/0.501
4yagNAIC alpha-dehydrogenase/0.501
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.500
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.500
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.499
4dc1NDPPutative ketoacyl reductase1.3.10.498
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.497
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.497
4gh5NADShort-chain dehydrogenase/reductase SDR/0.497
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.496
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.496
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.496
3ai3NDPNADPH-sorbose reductase/0.495
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.495
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.495
4qecNAPElxO/0.492
1snyNAPLD36273p/0.491
1zemNADXylitol dehydrogenase/0.490
3lqfNADGalactitol dehydrogenase/0.490
3s55NADPutative short-chain dehydrogenase/reductase/0.490
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.490
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.488
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.487
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.487
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.486
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.485
1wntNAPL-xylulose reductase1.1.1.100.485
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.485
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.485
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.485
4fn4NADShort chain dehydrogenase/0.484
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.483
3d3wNAPL-xylulose reductase1.1.1.100.483
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.481
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.479
3l77NJPShort-chain alcohol dehydrogenase/0.479
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
2bd0NAPSepiapterin reductase/0.477
3ak4NADNADH-dependent quinuclidinone reductase/0.477
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.475
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.475
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.475
4esoNAPPutative oxidoreductase/0.474
4nbwNADShort-chain dehydrogenase/reductase SDR/0.474
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.473
5jydNADShort chain dehydrogenase/0.473
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.469
2c0cNAPProstaglandin reductase 310.468
3r3sNADPutative oxidoreductase/0.468
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.467
1sbyNADAlcohol dehydrogenase1.1.1.10.466
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.465
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.465
1mg5NAIAlcohol dehydrogenase1.1.1.10.463
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.462
3rj5NADAlcohol dehydrogenase1.1.1.10.462
3rj9NADAlcohol dehydrogenase1.1.1.10.462
3sx2NADUncharacterized protein/0.462
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.462
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.461
2p5uNADUDP-glucose 4-epimerase/0.461
3gw9VNILanosterol 14-alpha-demethylase/0.461
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.461
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.460
3bmoNAPPteridine reductase/0.460
4b8zNAPGDP-L-fucose synthase1.1.1.2710.460
4q71FADBifunctional protein PutA/0.460
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.459
3tn7NJPShort-chain alcohol dehydrogenase/0.459
4impNDPPolyketide synthase extender modules 3-4/0.459
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.457
3uxyNADShort-chain dehydrogenase/reductase SDR/0.457
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
5lc1NADL-threonine 3-dehydrogenase/0.457
4qedNAPElxO/0.456
3tscNADUncharacterized protein/0.447
4g3jVNTLanosterol 14-alpha-demethylase/0.447
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.445
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3uceNDPDehydrogenase/0.445
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
5emhNAPIridoid synthase1.3.1.990.443
2g5cNADPrephenate dehydrogenase/0.442
3u4cNDPNADPH-dependent reductase BacG/0.442
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.441
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.441
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.441
1b15NAEAlcohol dehydrogenase1.1.1.10.440
2nq8ZIDEnoyl-ACP reductase/0.440
3a4vNADNDP-sugar epimerase/0.440