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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w2cN15Aurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w2cN15Aurora kinase A2.7.11.11.000
3w18N13Aurora kinase A2.7.11.10.474
3abaFLICytochrome P450/0.466
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.453
5dozNDPJamJ/0.450
2c6eHPMAurora kinase A2.7.11.10.446
3u1y03IUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.443
4wriOKAOkadaic acid binding protein 2-alpha/0.443
3h0aD30Peroxisome proliferator-activated receptor gamma/0.441