scPDB - Distribution of Binding site Similarity values of 3vzd entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3vzd	UUL	Sphingosine kinase 1	2.7.1.91

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3vzd	UUL	Sphingosine kinase 1	2.7.1.91	1.000
3vzc	UUL	Sphingosine kinase 1	2.7.1.91	0.683
4l02	1V2	Sphingosine kinase 1	2.7.1.91	0.629
1pp9	SMA	Cytochrome b	/	0.483
3bus	SAH	Demethylrebeccamycin-D-glucose O-methyltransferase	/	0.472
1qxl	FR8	Adenosine deaminase	3.5.4.4	0.471
3p9t	TCL	Repressor	/	0.466
4jkt	04A	Glutaminase kidney isoform, mitochondrial	3.5.1.2	0.466
4tzt	468	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.466
1uml	FR4	Adenosine deaminase	3.5.4.4	0.464
4anm	WUL	Casein kinase II subunit alpha	2.7.11.1	0.464
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.463
3nwl	NDP	Catalase	1.11.1.6	0.463
3cxh	SMA	Cytochrome b	/	0.462
3fco	IIG	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.462
3w0a	DS5	Vitamin D3 receptor	/	0.462
1o5r	FR9	Adenosine deaminase	3.5.4.4	0.461
3w0c	6DS	Vitamin D3 receptor	/	0.461
1bvr	THT	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.460
2om9	AJA	Peroxisome proliferator-activated receptor gamma	/	0.460
5cp8	TCU	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.460
7cat	NDP	Catalase	1.11.1.6	0.460
1fvp	FMA	Non-fluorescent flavoprotein	/	0.459
1p44	GEQ	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.458
1ygk	RRC	Pyridoxal kinase	2.7.1.35	0.458
5iub	CLR	Adenosine receptor A2a	/	0.458
1cjc	FAD	NADPH:adrenodoxin oxidoreductase, mitochondrial	1.18.1.6	0.456
1dgh	NDP	Catalase	1.11.1.6	0.456
3czr	3CZ	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.456
4j6c	STR	Cytochrome P450 monooxygenase	/	0.456
4qzu	RTL	Retinol-binding protein 2	/	0.456
2ilt	NN1	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.455
4plp	NAD	Homospermidine synthase	2.5.1.44	0.455
5epe	SAH	Uncharacterized protein	/	0.455
4bfp	SWY	Tankyrase-2	2.4.2.30	0.454
8cat	NDP	Catalase	1.11.1.6	0.454
1qnf	HDF	Deoxyribodipyrimidine photo-lyase	4.1.99.3	0.453
2q9f	C3S	Cholesterol 24-hydroxylase	/	0.453
3vt3	VDX	Vitamin D3 receptor	/	0.453
4cnj	FAD	L-amino acid oxidase	/	0.453
4tzk	641	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.453
1ezv	SMA	Cytochrome b	/	0.452
1ndz	FR5	Adenosine deaminase	3.5.4.4	0.452
2agv	TG1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	3.6.3.8	0.452
3u8h	BHP	Phospholipase A2, membrane associated	/	0.452
4i9i	1DY	Tankyrase-1	2.4.2.30	0.452
4j6d	TES	Cytochrome P450 monooxygenase	/	0.452
1fm9	570	Peroxisome proliferator-activated receptor gamma	/	0.451
1o1v	TCH	Gastrotropin	/	0.451
2w98	P1Z	Prostaglandin reductase 2	1.3.1.48	0.451
4anv	751	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.451
4wuo	NAD	3-isopropylmalate dehydrogenase	1.1.1.85	0.451
1kvo	OAP	Phospholipase A2, membrane associated	/	0.450
3gkj	HC3	Niemann-Pick C1 protein	/	0.450
1e1l	FAD	NADPH:adrenodoxin oxidoreductase, mitochondrial	1.18.1.6	0.449
1ma0	NAD	Alcohol dehydrogenase class-3	1.1.1.1	0.449
1rkg	VD1	Vitamin D3 receptor	/	0.449
4jbt	ASD	Cytochrome P450 monooxygenase	/	0.449
1zgy	BRL	Peroxisome proliferator-activated receptor gamma	/	0.448
2ovh	AS0	Progesterone receptor	/	0.448
3ant	S82	Bifunctional epoxide hydrolase 2	3.3.2.10	0.448
3juh	ANP	Casein kinase II subunit alpha	2.7.11.1	0.448
4trj	665	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.448
1e1k	FAD	NADPH:adrenodoxin oxidoreductase, mitochondrial	1.18.1.6	0.447
3cx5	SMA	Cytochrome b	/	0.447
3irx	UDR	Gag-Pol polyprotein	2.7.7.49	0.447
4g67	SAH	Uncharacterized ACR, COG1565 superfamily	/	0.447
4nmd	FDA	Bifunctional protein PutA	/	0.447
2xvu	9DN	Serum albumin	/	0.446
3otq	MZL	Bifunctional epoxide hydrolase 2	3.3.2.10	0.446
3t7x	4SH	Endothiapepsin	3.4.23.22	0.446
3zk5	Z18	Cytochrome P450 monooxygenase PikC	/	0.446
1d3g	BRE	Dihydroorotate dehydrogenase (quinone), mitochondrial	1.3.5.2	0.445
1olm	VTQ	SEC14-like protein 2	/	0.445
1opb	RET	Retinol-binding protein 2	/	0.445
1yin	CM3	Estrogen receptor	/	0.445
2hcd	BIV	Vitamin D3 receptor A	/	0.445
2o4r	VD5	Vitamin D3 receptor	/	0.445
4kf1	HT5	Aryldialkylphosphatase	3.1.8.1	0.445
4lxh	C1E	Alpha/beta hydrolase fold	/	0.445
4mih	FAD	Pyranose 2-oxidase	1.1.3.10	0.445
4xrg	NAD	Homospermidine synthase	2.5.1.44	0.445
5ab6	CAA	Nonspecific lipid-transfer protein, putative	/	0.445
5iu8	6DZ	Adenosine receptor A2a	/	0.445
1h36	R88	Squalene--hopene cyclase	4.2.1.129	0.444
1n4h	REA	Nuclear receptor ROR-beta	/	0.444
1sui	FRE	Caffeoyl-CoA O-methyltransferase	2.1.1.104	0.444
4h4o	506	Gag-Pol polyprotein	2.7.7.49	0.444
5k2b	ZMA	Adenosine receptor A2a	/	0.444
1p91	SAM	23S rRNA (guanine(745)-N(1))-methyltransferase	/	0.443
2bel	CBO	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.443
2ivp	ATP	tRNA N6-adenosine threonylcarbamoyltransferase	/	0.443
2ylt	FAD	Phenylacetone monooxygenase	1.14.13.92	0.443
3a78	3EV	Vitamin D3 receptor	/	0.443
3ar4	TG1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	3.6.3.8	0.443
1dgf	NDP	Catalase	1.11.1.6	0.442
3pww	ROC	Endothiapepsin	3.4.23.22	0.442
5jtb	ZMA	Adenosine receptor A2a	/	0.442
1fp1	HCC	Isoliquiritigenin 2'-O-methyltransferase	/	0.441
1ppj	ANY	Cytochrome b	/	0.441
2fzm	FAD	Bifunctional protein PutA	1.5.5.2	0.441
2phk	ATP	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	2.7.11.19	0.441
3cwk	REA	Cellular retinoic acid-binding protein 2	/	0.441
3d3e	D3E	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.441
3h6k	33T	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.441
3ojx	NAP	NADPH--cytochrome P450 reductase	/	0.441
4fv7	E94	Mitogen-activated protein kinase 1	2.7.11.24	0.441
4irn	FAD	AnaB	/	0.441
4mq2	2C4	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	2.7.12.1	0.441
4xsr	UPG	Alr3699 protein	/	0.441
1fmj	RTL	Retinol dehydratase	/	0.440
1sj0	E4D	Estrogen receptor	/	0.440
2ham	C33	Vitamin D3 receptor	/	0.440
2vnh	FAD	NADPH:ferredoxin reductase	/	0.440
2zb8	IMN	Prostaglandin reductase 2	1.3.1.48	0.440
3kpz	ZNE	Vitamin D3 receptor	/	0.440
4bca	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.440
4eev	L1X	Hepatocyte growth factor receptor	2.7.10.1	0.440
4xq9	NAD	Homospermidine synthase	2.5.1.44	0.440
5ab7	MLC	Nonspecific lipid-transfer protein, putative	/	0.440
5hs1	VOR	Lanosterol 14-alpha demethylase	/	0.440