sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3vtk | ADP | Thymidine kinase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3vtk | ADP | Thymidine kinase | / | 1.000 | |
| 2ql6 | ADP | Nicotinamide riboside kinase 1 | / | 0.556 | |
| 1w5s | ADP | ORC1-type DNA replication protein 2 | / | 0.545 | |
| 3w8r | ACP | Uridine kinase | / | 0.531 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.508 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.508 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.507 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.505 | |
| 3pfi | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.503 | |
| 4jsy | GTP | Metallophosphoesterase | / | 0.503 | |
| 4gp6 | ADP | Metallophosphoesterase | / | 0.502 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.501 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.498 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.496 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.496 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.493 | |
| 1w5t | ADP | ORC1-type DNA replication protein 2 | / | 0.492 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.491 | |
| 5i4n | ATP | Tyrosine-protein kinase JAK2 | / | 0.490 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.489 | |
| 2eu8 | AP5 | Adenylate kinase | / | 0.489 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.489 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.488 | |
| 1ank | ANP | Adenylate kinase | / | 0.486 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.486 | |
| 1p4a | PCP | Pur operon repressor | / | 0.485 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.485 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.485 | |
| 5ftc | ADP | TPR domain protein | / | 0.485 | |
| 1e4y | AP5 | Adenylate kinase | / | 0.483 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.483 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.482 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 4i9a | NCN | Nicotinate-nucleotide pyrophosphorylase [carboxylating] | / | 0.482 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.481 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.481 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.480 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.480 | |
| 2w02 | ATP | AcsD | / | 0.480 | |
| 3hpr | AP5 | Adenylate kinase | / | 0.480 | |
| 4e07 | ACP | Plasmid partitioning protein ParF | / | 0.480 | |
| 1ht2 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.479 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.479 | |
| 4die | C5P | Cytidylate kinase | / | 0.479 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1m2o | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.476 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.476 | |
| 2qaj | AP5 | Adenylate kinase | / | 0.476 | |
| 4typ | AP5 | Adenylate kinase | / | 0.476 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.476 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.475 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.475 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.475 | |
| 5kj6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.475 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.473 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.472 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.472 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.472 | |
| 4rx6 | ATP | Nitrogen regulatory PII-like protein | / | 0.472 | |
| 1u9i | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.471 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.471 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.471 | |
| 1g6o | ADP | Cag alpha | / | 0.470 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.470 | |
| 1tf7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.470 | |
| 2wlf | ACO | Polysialic acid O-acetyltransferase | / | 0.470 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 5ero | 210 | Fusicoccadiene synthase | 2.5.1.29 | 0.470 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.469 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.469 | |
| 2pb2 | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.469 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.469 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.469 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.469 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.469 | |
| 4y0v | GDP | ADP-ribosylation factor 1, putative | / | 0.469 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.469 | |
| 4jld | ADP | Adenylate kinase | / | 0.468 | |
| 4qbf | AP5 | Adenylate kinase | / | 0.468 | |
| 4qbg | AP5 | Adenylate kinase | / | 0.468 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.467 | |
| 4ylg | GDP | ADP-ribosylation factor 1, putative | / | 0.467 | |
| 2ax4 | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 2.7.1.25 | 0.466 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.466 | |
| 1ytm | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.465 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.465 | |
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.465 | |
| 4o4i | GTP | Tubulin alpha-1B chain | / | 0.465 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.465 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.464 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1q43 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.464 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.464 | |
| 1sb8 | UD2 | WbpP | / | 0.464 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.464 | |
| 2vp4 | DCP | Deoxynucleoside kinase | / | 0.464 | |
| 3tif | ADP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.464 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.464 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.463 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.463 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.463 | |
| 1zcb | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.463 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.463 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.462 | |
| 2imk | GTX | AGAP009194-PA | / | 0.462 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.462 | |
| 3tlx | ADP | Adenylate kinase 2 | / | 0.462 | |
| 4d7t | CMP | Uncharacterized protein | / | 0.462 | |
| 1fyf | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.461 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.461 | |
| 2x3j | ATP | AcsD | / | 0.461 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.461 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.461 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.461 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4oi2 | ADP | Protein clpf-1 | / | 0.461 | |
| 1i7l | ATP | Synapsin-2 | / | 0.460 | |
| 1rj9 | GCP | Signal recognition particle receptor FtsY | / | 0.460 | |
| 1w49 | APC | NTPase P4 | / | 0.460 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.460 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.460 | |
| 3dyh | 721 | Farnesyl pyrophosphate synthase | / | 0.460 | |
| 3qe0 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.460 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.460 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.460 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.460 | |
| 5fm6 | ADP | RuvB-like helicase | / | 0.460 | |
| 1e4v | AP5 | Adenylate kinase | / | 0.459 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.459 | |
| 4fcw | ADP | Chaperone protein ClpB | / | 0.459 | |
| 4xj3 | GTP | Cyclic GMP-AMP synthase | / | 0.459 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.459 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.458 | |
| 1wvg | CXY | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.458 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.458 | |
| 2wzm | NA7 | Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 | / | 0.458 | |
| 3e8x | NAP | BH1520 protein | / | 0.458 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.458 | |
| 4lj9 | ACP | Chaperone protein ClpB | / | 0.458 | |
| 1kf6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.457 | |
| 1xbt | TTP | Thymidine kinase, cytosolic | 2.7.1.21 | 0.457 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.457 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.457 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2q16 | ITT | dITP/XTP pyrophosphatase | / | 0.457 | |
| 3dkv | AP5 | Adenylate kinase | / | 0.457 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.457 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.457 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.456 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.456 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.456 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.456 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.456 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.456 | |
| 4mkg | AP5 | Adenylate kinase | / | 0.456 | |
| 4qbh | AP5 | Adenylate kinase | / | 0.456 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.456 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.455 | |
| 5l3s | GNP | Signal recognition particle receptor FtsY | / | 0.455 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.454 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1u28 | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.454 | |
| 1y8q | ATP | SUMO-activating enzyme subunit 2 | 6.3.2 | 0.454 | |
| 2iyp | A2P | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.454 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.454 | |
| 2wgh | DTP | Ribonucleoside-diphosphate reductase large subunit | 1.17.4.1 | 0.454 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.454 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.454 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3fro | NHF | GlgA glycogen synthase | / | 0.454 | |
| 3mw9 | NAI | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.454 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.454 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.454 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.454 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.454 | |
| 4o4i | ACP | Tubulin tyrosine ligase | / | 0.454 | |
| 1cg0 | IMO | Adenylosuccinate synthetase | / | 0.453 | |
| 1dvr | ATF | Adenylate kinase | / | 0.453 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.453 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.453 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.453 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.453 | |
| 2ou5 | FMN | Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein | / | 0.453 | |
| 2y3s | TIR | TamL | / | 0.453 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.453 | |
| 3qtt | ANP | Pantothenate synthetase | / | 0.453 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.453 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.453 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.453 | |
| 1ebl | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.452 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.452 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.452 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.452 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 4qm6 | GTP | Metallophosphoesterase | / | 0.452 | |
| 5aga | ANP | DNA polymerase theta | / | 0.452 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.452 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.452 | |
| 1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 2azn | NAP | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase | / | 0.451 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.451 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.451 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.451 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.451 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.451 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.451 | |
| 3zl8 | ADP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.451 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.451 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 4zrn | UPG | UDP-glucose 4-epimerase, putative | / | 0.451 | |
| 1oyy | AGS | ATP-dependent DNA helicase RecQ | 3.6.4.12 | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2olr | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.450 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.450 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.450 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 4je7 | BB2 | Peptide deformylase 1A, chloroplastic/mitochondrial | 3.5.1.88 | 0.450 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.450 | |
| 5da9 | AGS | Uncharacterized protein | / | 0.450 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.449 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.449 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.449 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.449 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.449 | |
| 2ycn | P61 | Tyrosine phenol-lyase | 4.1.99.2 | 0.449 | |
| 3clt | FAD | Electron transfer flavoprotein subunit alpha | / | 0.449 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.449 | |
| 4gu5 | FAD | Cryptochrome-1 | / | 0.449 | |
| 4v02 | ATP | Site-determining protein | / | 0.449 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.448 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.448 | |
| 2vhw | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.448 | |
| 2wvj | TTP | Thymidine kinase, cytosolic | 2.7.1.21 | 0.448 | |
| 2zrj | AGS | Protein RecA | / | 0.448 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.448 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.448 | |
| 3onw | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.448 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.448 | |
| 4iij | GTP | Tubulin alpha-1B chain | / | 0.448 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.448 | |
| 1l7e | NAI | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.447 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.447 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.447 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.447 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3c41 | ANP | Amino acid ABC transporter | / | 0.447 | |
| 3egt | 722 | Farnesyl pyrophosphate synthase | / | 0.447 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.447 | |
| 3krf | IPE | Geranyl diphosphate synthase large subunit | / | 0.447 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.447 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.447 | |
| 4zol | GTP | Tubulin alpha-1B chain | / | 0.447 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.446 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2w03 | ADN | AcsD | / | 0.446 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.446 | |
| 3hdy | FDA | UDP-galactopyranose mutase | / | 0.446 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.446 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.446 | |
| 4loh | 1SY | Stimulator of interferon genes protein | / | 0.446 | |
| 4qbi | AP5 | Adenylate kinase | / | 0.446 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.446 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.445 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.445 | |
| 1zio | AP5 | Adenylate kinase | / | 0.445 | |
| 2e2q | ADP | ATP-dependent hexokinase | / | 0.445 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.445 | |
| 3fce | ATP | D-alanine--poly(phosphoribitol) ligase subunit 1 | / | 0.445 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.445 | |
| 3u11 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.445 | |
| 3ute | FAD | UDP-galactopyranose mutase | / | 0.445 | |
| 3x21 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.445 | |
| 4abz | T1C | Tetracycline repressor protein class D | / | 0.445 | |
| 4h4w | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.445 | |
| 4jy2 | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.445 | |
| 4ohx | ADP | Protein clpf-1 | / | 0.445 | |
| 4ww4 | ADP | RuvB-like helicase | / | 0.445 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.444 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1svh | I08 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 1xmv | ADP | Protein RecA | / | 0.444 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.444 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.444 | |
| 2o12 | FMN | Chorismate synthase | / | 0.444 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.444 | |
| 3ta0 | ATP | Nitrogen regulatory protein P-II (GlnB-3) | / | 0.444 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.444 | |
| 4rph | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.444 | |
| 4u8o | FDA | UDP-galactopyranose mutase | / | 0.444 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.444 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.443 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.443 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2aky | AP5 | Adenylate kinase | / | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.443 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.443 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 2r7p | ANP | Non-structural protein 2 | 3.6.4 | 0.443 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.443 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.443 | |
| 3pxv | FMN | Nitroreductase | / | 0.443 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.443 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.443 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.443 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 4tle | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.443 | |
| 4x8l | AP5 | Adenylate kinase | / | 0.443 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.443 | |
| 5doz | NDP | JamJ | / | 0.443 | |
| 5ej5 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.442 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.442 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.442 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.442 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.442 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.442 | |
| 3pdu | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.442 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.442 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.442 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.442 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.442 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1ht0 | NAD | Alcohol dehydrogenase 1C | 1.1.1.1 | 0.441 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.441 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.441 | |
| 1z5a | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.441 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.441 | |
| 2j4l | UTP | Uridylate kinase | 2.7.4.22 | 0.441 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.441 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.441 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 3m6v | SAM | Ribosomal RNA small subunit methyltransferase F | / | 0.441 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.441 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.441 | |
| 4or0 | NPS | Serum albumin | / | 0.441 | |
| 4ucz | GMP | Large structural protein | / | 0.441 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.440 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.440 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 2opm | NI9 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.440 | |
| 2pz8 | APC | NH(3)-dependent NAD(+) synthetase | / | 0.440 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.440 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.440 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3krf | DST | Geranyl diphosphate synthase large subunit | / | 0.440 | |
| 3nbv | ANP | Ketohexokinase | / | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 4i1v | ADP | Dephospho-CoA kinase | / | 0.440 | |
| 4iaz | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4p13 | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.440 |