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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vs6VSHTyrosine-protein kinase HCK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vs6VSHTyrosine-protein kinase HCK2.7.10.21.000
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.658
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.653
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.648
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.628
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.608
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.608
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.606
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.603
3vryB43Tyrosine-protein kinase HCK2.7.10.20.603
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.597
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.590
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.584
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.571
3vs1VSATyrosine-protein kinase HCK2.7.10.20.568
3vs3VSETyrosine-protein kinase HCK2.7.10.20.566
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.559
3w33W19Epidermal growth factor receptor2.7.10.10.549
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.548
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.541
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.541
4id71G0Activated CDC42 kinase 1/0.537
4hjoAQ4Epidermal growth factor receptor2.7.10.10.535
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.533
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.527
1xkkFMMEpidermal growth factor receptor2.7.10.10.523
4i22IREEpidermal growth factor receptor2.7.10.10.516
2hk51BMTyrosine-protein kinase HCK2.7.10.20.515
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.507
3l8p0CEAngiopoietin-1 receptor2.7.10.10.505
4nka2K7Fibroblast growth factor receptor 1/0.502
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.498
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.497
2c6eHPMAurora kinase A2.7.11.10.496
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3uvqFS8Mitogen-activated protein kinase 14/0.495
4nk92K5Fibroblast growth factor receptor 1/0.494
3w32W32Epidermal growth factor receptor2.7.10.10.492
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.490
3w18N13Aurora kinase A2.7.11.10.486
3w2sW2REpidermal growth factor receptor2.7.10.10.485
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.485
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.484
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.483
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.483
1bygSTUTyrosine-protein kinase CSK/0.482
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4aotGW8Serine/threonine-protein kinase 102.7.11.10.482
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.482
3poz03PEpidermal growth factor receptor2.7.10.10.481
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.480
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
2of2547Tyrosine-protein kinase Lck2.7.10.20.479
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.479
2itnANPEpidermal growth factor receptor2.7.10.10.478
3w2rW2REpidermal growth factor receptor2.7.10.10.477
3ds6A17Mitogen-activated protein kinase 14/0.476
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.476
4gk2L66Ephrin type-A receptor 32.7.10.10.476
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.475
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.473
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.473
2of4979Tyrosine-protein kinase Lck2.7.10.20.473
4riyADPEpidermal growth factor receptor2.7.10.10.473
3t2yFADSulfide-quinone reductase/0.471
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.470
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.469
2wotZZGTGF-beta receptor type-12.7.11.300.468
3ac2KSETyrosine-protein kinase Lck2.7.10.20.468
3ogqAB1Pol polyprotein/0.467
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.466
1idb0DOGag-Pol polyprotein/0.465
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.465
1u54ACPActivated CDC42 kinase 1/0.464
3icrCOACoenzyme A disulfide reductase/0.464
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.464
1m17AQ4Epidermal growth factor receptor2.7.10.10.463
3oom507Activin receptor type-12.7.11.300.463
3ttjJBIMitogen-activated protein kinase 102.7.11.240.463
4kip1R9Mitogen-activated protein kinase 14/0.463
1osvCHCBile acid receptor/0.462
1u4dDBQActivated CDC42 kinase 1/0.462
3gxlQIGTGF-beta receptor type-12.7.11.300.462
3s4qNK0Mitogen-activated protein kinase 14/0.462
1mesDMPGag-Pol polyprotein3.4.23.160.461
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
2vwz7X6Ephrin type-B receptor 42.7.10.10.461
3w8wFADPutative FAD-dependent oxygenase EncM/0.461
4c62XWWTyrosine-protein kinase JAK2/0.461
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.461
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.460
4aa5NQBMitogen-activated protein kinase 14/0.460
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2fgiPD1Fibroblast growth factor receptor 1/0.459
2y01Y01Beta-1 adrenergic receptor/0.459
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.459
3iw8HIZMitogen-activated protein kinase 14/0.459
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.459
4z35ON9Lysophosphatidic acid receptor 1/0.459
1bveDMPGag-Pol polyprotein3.4.23.160.458
2itqITQEpidermal growth factor receptor2.7.10.10.458
2vwx7X4Ephrin type-B receptor 42.7.10.10.458
3b70NAPEnoyl reductase LovC10.458
4kiq1RAMitogen-activated protein kinase 14/0.458
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.457
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.457
3gc9B45Mitogen-activated protein kinase 112.7.11.240.457
3w2cN15Aurora kinase A2.7.11.10.457
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
1vjy460TGF-beta receptor type-12.7.11.300.456
3hmm855TGF-beta receptor type-12.7.11.300.456
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.456
4fob0USALK tyrosine kinase receptor2.7.10.10.456
4gk4L90Ephrin type-A receptor 32.7.10.10.456
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.456
5e8wSTUTGF-beta receptor type-12.7.11.300.456
2vx07X7Ephrin type-B receptor 42.7.10.10.455
2wouZZFTGF-beta receptor type-12.7.11.300.455
3gw9VNILanosterol 14-alpha-demethylase/0.455
3vjoANPEpidermal growth factor receptor2.7.10.10.455
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.454
2yaaATPDeath-associated protein kinase 2/0.454
4c4g7RODual specificity protein kinase TTK2.7.12.10.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
4jq8KJ8Epidermal growth factor receptor2.7.10.10.454
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
1rw8580TGF-beta receptor type-12.7.11.300.453
4jr3KJREpidermal growth factor receptor2.7.10.10.453
4nks2M2Fibroblast growth factor receptor 1/0.453
4yuqKS1Calmodulin-like domain protein kinase/0.453
1bvgDMPGag-Pol polyprotein3.4.23.160.452
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.452
3fskRO6Mitogen-activated protein kinase 14/0.452
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4dymIYZActivin receptor type-12.7.11.300.452
5aaaVGHALK tyrosine kinase receptor2.7.10.10.452
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.451
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.451
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.450
3fklFKLMitogen-activated protein kinase 14/0.450
4a6bQG8Gag-Pol polyprotein3.4.23.160.450
4aa4QC0Mitogen-activated protein kinase 14/0.450
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2pwlACPFibroblast growth factor receptor 2/0.449
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.449
4k2xFADPolyketide oxygenase/hydroxylase/0.449
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.448
2y03Y01Beta-1 adrenergic receptor/0.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.448
3iphG11Mitogen-activated protein kinase 14/0.448
3nww3NWMitogen-activated protein kinase 14/0.448
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.448
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
5e8xSTUTGF-beta receptor type-12.7.11.300.448
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.447
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.447
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.447
1qbsDMPGag-Pol polyprotein3.4.23.160.446
2gs7ANPEpidermal growth factor receptor2.7.10.10.446
2vww7X2Ephrin type-B receptor 42.7.10.10.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
3b6zCO7Enoyl reductase LovC10.446
3h0aD30Peroxisome proliferator-activated receptor gamma/0.446
4c4h7RODual specificity protein kinase TTK2.7.12.10.446
1c6yMK1Protease/0.445
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
1zemNADXylitol dehydrogenase/0.445
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.445
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.445
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.445
4bb432WEphrin type-B receptor 42.7.10.10.445
1meuDMPGag-Pol polyprotein3.4.23.160.444
1pjkANPCasein kinase II subunit alpha2.7.11.10.444
2j7t274Serine/threonine-protein kinase 102.7.11.10.444
2zybKSLTyrosine-protein kinase Lck2.7.10.20.444
3icsCOACoenzyme A disulfide reductase/0.444
3l8xN4DMitogen-activated protein kinase 14/0.444
3mtfA3FActivin receptor type-12.7.11.300.444
4aacAAVMitogen-activated protein kinase 14/0.444
4gk3L87Ephrin type-A receptor 32.7.10.10.444
4hee14RPeroxisome proliferator-activated receptor gamma/0.444
4ih8B43Calmodulin-domain protein kinase 1/0.444
4wa9AXITyrosine-protein kinase ABL12.7.10.20.444
1kk4ACOStreptogramin A acetyltransferase2.3.10.443
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
2ittAEEEpidermal growth factor receptor2.7.10.10.443
2itvANPEpidermal growth factor receptor2.7.10.10.443
2itzIREEpidermal growth factor receptor2.7.10.10.443
2vwu7X1Ephrin type-B receptor 42.7.10.10.443
2xp2VGHALK tyrosine kinase receptor2.7.10.10.443
2y02Y01Beta-1 adrenergic receptor/0.443
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.443
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.443
4g2fC07Ephrin type-A receptor 32.7.10.10.443
4j5j478Gag-Pol polyprotein3.4.23.160.443
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.443
1ppjSMACytochrome b/0.442
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
2cig1DGDihydrofolate reductase1.5.1.30.442
2vwy7X5Ephrin type-B receptor 42.7.10.10.442
3mg3ECHOrange carotenoid-binding protein/0.442
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.442
3r9dX6BCyclin-dependent kinase 22.7.11.220.442
3t2kFADSulfide-quinone reductase/0.442
3vt9YI4Vitamin D3 receptor/0.442
1ot7IU5Bile acid receptor/0.441
2aibERGBeta-elicitin cinnamomin/0.441
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.441
2jn3JN3Fatty acid-binding protein, liver/0.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2vx17X8Ephrin type-B receptor 42.7.10.10.441
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.441
3sz0FADSulfide-quinone reductase/0.441
5dozNDPJamJ/0.441
2vnaNAPProstaglandin reductase 21.3.1.480.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
3wmxNADNAD dependent epimerase/dehydratase/0.440
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.440
4z34ON7Lysophosphatidic acid receptor 1/0.440