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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vnt0JAVascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vnt0JAVascular endothelial growth factor receptor 22.7.10.11.000
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.580
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.564
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.564
2hyySTITyrosine-protein kinase ABL12.7.10.20.533
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.533
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.529
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.528
3efl706Vascular endothelial growth factor receptor 22.7.10.10.515
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.514
3hng8STVascular endothelial growth factor receptor 12.7.10.10.514
1iepSTITyrosine-protein kinase ABL12.7.10.20.509
4o2z046Mitogen-activated protein kinase/0.501
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4qrc0LIFibroblast growth factor receptor 42.7.10.10.485
3ce31FNHepatocyte growth factor receptor2.7.10.10.481
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.476
2og81N8Tyrosine-protein kinase Lck2.7.10.20.473
2xir00JVascular endothelial growth factor receptor 22.7.10.10.463
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.463
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.457
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.454
3hv5R24Mitogen-activated protein kinase 14/0.451
4aa0AA0Mitogen-activated protein kinase 14/0.451
4kaoKAOFocal adhesion kinase 12.7.10.20.451
3eta351Insulin receptor2.7.10.10.450
4eyjN61Mitogen-activated protein kinase 132.7.11.240.450
3ctj320Hepatocyte growth factor receptor2.7.10.10.447