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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vhkBPKVascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vhkBPKVascular endothelial growth factor receptor 22.7.10.11.000
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.666
3efl706Vascular endothelial growth factor receptor 22.7.10.10.607
3hng8STVascular endothelial growth factor receptor 12.7.10.10.590
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.589
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.583
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.581
2xir00JVascular endothelial growth factor receptor 22.7.10.10.562
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.552
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.551
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.542
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.539
2hyySTITyrosine-protein kinase ABL12.7.10.20.538
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.538
4eyjN61Mitogen-activated protein kinase 132.7.11.240.533
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.531
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.529
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.526
4o2z046Mitogen-activated protein kinase/0.521
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.519
1iepSTITyrosine-protein kinase ABL12.7.10.20.516
3hv5R24Mitogen-activated protein kinase 14/0.503
3kq7KQ7Mitogen-activated protein kinase 14/0.492
3eta351Insulin receptor2.7.10.10.488
3ce31FNHepatocyte growth factor receptor2.7.10.10.486
4aa0AA0Mitogen-activated protein kinase 14/0.485
1fm4DXCMajor pollen allergen Bet v 1-L/0.484
4a84DXCMajor pollen allergen Bet v 1-A/0.482
4eevL1XHepatocyte growth factor receptor2.7.10.10.482
2og81N8Tyrosine-protein kinase Lck2.7.10.20.475
3ctj320Hepatocyte growth factor receptor2.7.10.10.475
4kaoKAOFocal adhesion kinase 12.7.10.20.475
4qrc0LIFibroblast growth factor receptor 42.7.10.10.473
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.465
3k9vCPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial/0.465
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4l9q9TPSerum albumin/0.461
3iw8HIZMitogen-activated protein kinase 14/0.457
2c6eHPMAurora kinase A2.7.11.10.455
2dteNAIGlucose 1-dehydrogenase related protein/0.454
2o3zAI7UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.454
3lfbZ87Mitogen-activated protein kinase 14/0.453
5fknTDCTetracycline repressor protein class D/0.453
1rf9DBRCamphor 5-monooxygenase1.14.15.10.450
2y01Y01Beta-1 adrenergic receptor/0.450
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3ds6A17Mitogen-activated protein kinase 14/0.446
3p6oETGCamphor 5-monooxygenase1.14.15.10.446
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.445
1xddAAYIntegrin alpha-L/0.442
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.442
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.441
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.441
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4qe6JN3Bile acid receptor/0.440