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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.21.000
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.583
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.525
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.511
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.487
2j0m4STFocal adhesion kinase 12.7.10.20.484
3zewSTUEphrin type-B receptor 42.7.10.10.483
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.480
4i22IREEpidermal growth factor receptor2.7.10.10.480
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.478
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.478
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.477
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.477
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.476
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
2j7t274Serine/threonine-protein kinase 102.7.11.10.468
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.468
3r9dX6BCyclin-dependent kinase 22.7.11.220.468
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.467
2vrx447Aurora kinase B-A2.7.11.10.466
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.466
4nka2K7Fibroblast growth factor receptor 1/0.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
2vu3LZECyclin-dependent kinase 22.7.11.220.463
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.463
1aq1STUCyclin-dependent kinase 22.7.11.220.461
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.461
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.458
2bfyH1NAurora kinase B-A2.7.11.10.457
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.456
3d7tSTUTyrosine-protein kinase CSK/0.455
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.453
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.453
3w2sW2REpidermal growth factor receptor2.7.10.10.453
4id71G0Activated CDC42 kinase 1/0.453
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.452
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.451
3r9hZ67Cyclin-dependent kinase 22.7.11.220.449
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.447
4bcmT7ZCyclin-dependent kinase 22.7.11.220.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
2x6dX6DAurora kinase A2.7.11.10.446
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.446
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.445
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.445
5av2KMPDeath-associated protein kinase 12.7.11.10.445
3w2o03PEpidermal growth factor receptor2.7.10.10.444
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.444
4fob0USALK tyrosine kinase receptor2.7.10.10.444
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
5aaaVGHALK tyrosine kinase receptor2.7.10.10.444
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
3axwTIDCasein kinase II subunit alpha2.7.11.10.443
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.443
1bygSTUTyrosine-protein kinase CSK/0.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.442
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.442
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2c475IDCasein kinase I isoform gamma-2/0.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
4gk3L87Ephrin type-A receptor 32.7.10.10.441
2c4g514Cyclin-dependent kinase 22.7.11.220.440
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.440
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.440