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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.15

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.151.000
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.627
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.501
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.492
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
4fv6E57Mitogen-activated protein kinase 12.7.11.240.480
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
5av2KMPDeath-associated protein kinase 12.7.11.10.478
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2yaaATPDeath-associated protein kinase 2/0.473
3a8wATPProtein kinase C iota type2.7.11.130.473
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
5av3KMPDeath-associated protein kinase 12.7.11.10.468
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4otiMI1Serine/threonine-protein kinase N1/0.467
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3ncz3NCRho-associated protein kinase 12.7.11.10.464
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.455
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3i60E86Mitogen-activated protein kinase 12.7.11.240.455
3lltANPProtein serine/threonine kinase-1/0.455
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.453
1jklANPDeath-associated protein kinase 12.7.11.10.450
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
5aut2ANDeath-associated protein kinase 12.7.11.10.450
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
3juhANPCasein kinase II subunit alpha2.7.11.10.447
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.446
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3zh8C58Protein kinase C iota type2.7.11.130.445
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.444
4aguD15Cyclin-dependent kinase-like 1/0.443
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.441
4ysjADPCalmodulin-like domain protein kinase/0.441
3dqrJI2Nitric oxide synthase, brain1.14.13.390.440