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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uzaT4GAdenosine receptor A2a

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uzaT4GAdenosine receptor A2a/1.000
3uzcT4EAdenosine receptor A2a/0.642
3reyXACAdenosine receptor A2a/0.641
3rfmCFFAdenosine receptor A2a/0.601
3qakUKAAdenosine receptor A2a/0.529
3t8xT8XT-cell surface glycoprotein CD1b/0.489
1xddAAYIntegrin alpha-L/0.481
5k2dZMAAdenosine receptor A2a/0.477
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.473
5iua6DXAdenosine receptor A2a/0.470
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.469
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.469
3l6jZ90Alr2278 protein/0.469
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.466
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
1q5dEPBEpothilone C/D epoxidase1.140.465
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.460
3p99LNPLanosterol 14-alpha-demethylase/0.458
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.458
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
3a1l2CCCytochrome P450/0.457
4iae1DXAlr2278 protein/0.457
3emlZMAAdenosine receptor A2a/0.456
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.454
3abaFLICytochrome P450/0.453
4ib4ERM5-hydroxytryptamine receptor 2B/0.453
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4iarERM5-hydroxytryptamine receptor 1B/0.452
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.450
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.450
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.447
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4fhf0TTSpore photoproduct lyase/0.447
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4jqh1MFAlr2278 protein/0.445
1pkfEPDEpothilone C/D epoxidase1.140.444
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.444
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4j6cSTRCytochrome P450 monooxygenase/0.443
3u8hBHPPhospholipase A2, membrane associated/0.442
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4iah1DXAlr2278 protein/0.440
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.440