scPDB - Distribution of Binding site Similarity values of 3upt entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3upt	TPP	Transketolase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3upt	TPP	Transketolase	/	1.000
1itz	TPP	Transketolase, chloroplastic	2.2.1.1	0.640
2r5n	TPP	Transketolase 1	/	0.636
1tkb	N1T	Transketolase 1	2.2.1.1	0.617
1trk	TPP	Transketolase 1	2.2.1.1	0.612
1ngs	TPP	Transketolase 1	2.2.1.1	0.607
1ay0	TPP	Transketolase 1	2.2.1.1	0.602
1tka	N3T	Transketolase 1	2.2.1.1	0.599
1tkc	M6T	Transketolase 1	2.2.1.1	0.579
3rim	TPP	Transketolase	2.2.1.1	0.569
2g25	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.506
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.505
1umc	TDP	2-oxoisovalerate dehydrogenase subunit alpha	1.2.4.4	0.501
1umc	TDP	2-oxoisovalerate dehydrogenase subunit beta	1.2.4.4	0.501
2o1x	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.486
2iea	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.481
3lq4	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.467
1rp7	TZD	Pyruvate dehydrogenase E1 component	1.2.4.1	0.466
3lq2	TDP	Pyruvate dehydrogenase E1 component	1.2.4.1	0.465
2zb8	IMN	Prostaglandin reductase 2	1.3.1.48	0.459
2j9f	THV	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	1.2.4.4	0.456
2j9f	THV	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	1.2.4.4	0.456
1fml	RTL	Retinol dehydratase	/	0.453
4h6p	FMN	Chromate reductase	/	0.446
2g28	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.442
3zhu	TD8	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.440