sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 1.000 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.760 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.688 | |
| 3cse | N22 | Uncharacterized protein | / | 0.640 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.628 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.620 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.619 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.619 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.616 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.616 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.615 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.613 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.613 | |
| 3qly | 55V | Uncharacterized protein | / | 0.610 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.609 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.608 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.608 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.606 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.604 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.603 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.602 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.599 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.596 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.595 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.593 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.591 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.591 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.591 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.590 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.590 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.589 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.589 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.589 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.587 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.587 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.586 | |
| 3eej | 53R | Uncharacterized protein | / | 0.584 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.584 | |
| 3eem | 53V | Uncharacterized protein | / | 0.578 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.577 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.577 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.573 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.572 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.569 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.569 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 3eek | 53S | Uncharacterized protein | / | 0.560 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.560 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.560 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.555 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.551 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.550 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 3eel | 53T | Uncharacterized protein | / | 0.549 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.548 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.546 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.546 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.539 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.537 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.537 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.535 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.534 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.532 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.531 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.527 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.526 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.522 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.517 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.512 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.511 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.506 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.505 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.502 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.500 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.498 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.495 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.494 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.494 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.494 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.493 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.493 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.493 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.493 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.493 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.491 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 2p15 | EZT | Estrogen receptor | / | 0.490 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.490 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.490 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.488 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.487 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.485 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.485 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 2ocf | EST | Estrogen receptor | / | 0.484 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.484 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.484 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.484 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.483 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.482 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1zky | 689 | Estrogen receptor | / | 0.482 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.482 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.481 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.481 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.480 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.479 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.479 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.479 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.479 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.478 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.478 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.478 | |
| 4zas | TYD | CalS13 | / | 0.478 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.477 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.477 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.477 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.476 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.475 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.475 | |
| 2jfa | RAL | Estrogen receptor | / | 0.475 | |
| 3oll | EST | Estrogen receptor beta | / | 0.475 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.474 | |
| 3q95 | ESL | Estrogen receptor | / | 0.474 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.474 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.474 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.473 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.472 | |
| 2b1z | 17M | Estrogen receptor | / | 0.472 | |
| 2jf9 | OHT | Estrogen receptor | / | 0.472 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 2pog | WST | Estrogen receptor | / | 0.472 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 3uud | EST | Estrogen receptor | / | 0.472 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.472 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.471 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.471 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.471 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.471 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.471 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.471 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.471 | |
| 1l2i | ETC | Estrogen receptor | / | 0.470 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.470 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.470 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.470 | |
| 3iqe | F42 | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.470 | |
| 3p9t | TCL | Repressor | / | 0.470 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.470 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.470 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.469 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.469 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.469 | |
| 1osv | CHC | Bile acid receptor | / | 0.469 | |
| 2g44 | T3O | Estrogen receptor | / | 0.469 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.469 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.469 | |
| 3zux | TCH | Transporter | / | 0.469 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.469 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.469 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.468 | |
| 2c7g | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.468 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.468 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.468 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.468 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.468 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.467 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 2bj4 | OHT | Estrogen receptor | / | 0.467 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.467 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.467 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.467 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.466 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.466 | |
| 2l98 | STL | Troponin C, slow skeletal and cardiac muscles | / | 0.466 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.466 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.465 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.465 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.465 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.465 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.465 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.465 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.464 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.464 | |
| 2jj3 | JJ3 | Estrogen receptor beta | / | 0.464 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.464 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.464 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.464 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.464 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.464 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.464 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.463 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.463 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.463 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.463 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.463 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.463 | |
| 3dmj | GWE | Pol protein | / | 0.463 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.463 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.462 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.462 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.462 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.462 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.462 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.462 | |
| 1nde | MON | Estrogen receptor beta | / | 0.461 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.461 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.461 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.461 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.461 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.461 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.461 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.461 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.460 | |
| 1cqs | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.460 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.460 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.460 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.460 | |
| 1yim | CM4 | Estrogen receptor | / | 0.460 | |
| 1ysx | 4EB | Serum albumin | / | 0.460 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.460 | |
| 2cdc | NAP | Glucose 1-dehydrogenase | / | 0.460 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.460 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.460 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.460 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.460 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.460 | |
| 5a28 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.459 | |
| 2yhd | TES | Androgen receptor | / | 0.459 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.459 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.459 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.459 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.459 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.459 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 4k7a | DHT | Androgen receptor | / | 0.459 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.458 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.458 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.458 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.458 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.458 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1gwr | EST | Estrogen receptor | / | 0.457 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.457 | |
| 1u3r | 338 | Estrogen receptor beta | / | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.457 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.457 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.457 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.457 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.456 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.456 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.456 | |
| 3tdl | 11D | Serum albumin | / | 0.456 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.456 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.456 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.455 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.455 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 2ejz | SAH | Diphthine synthase | / | 0.455 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.455 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.455 | |
| 2qgt | EED | Estrogen receptor | / | 0.455 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.455 | |
| 3m09 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4l8u | 9AZ | Serum albumin | / | 0.455 | |
| 4lb2 | DM5 | Serum albumin | / | 0.455 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.455 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.454 | |
| 1rt5 | UC2 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.454 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.454 | |
| 1x78 | 244 | Estrogen receptor beta | / | 0.454 | |
| 1xp1 | AIH | Estrogen receptor | / | 0.454 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.454 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.454 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.454 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.454 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4j24 | EST | Estrogen receptor beta | / | 0.454 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 2ouz | C3D | Estrogen receptor | / | 0.453 | |
| 2yne | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.453 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.453 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.453 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.453 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 5dxg | EST | Estrogen receptor | / | 0.453 | |
| 5hyr | EST | Estrogen receptor | / | 0.453 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1g50 | EST | Estrogen receptor | / | 0.452 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.452 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1x7e | 244 | Estrogen receptor | / | 0.452 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.452 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2fai | 459 | Estrogen receptor | / | 0.452 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.452 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.452 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.452 | |
| 2q7k | TES | Androgen receptor | / | 0.452 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3lu8 | IQX | Serum albumin | / | 0.452 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.452 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.451 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.451 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.451 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.451 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.451 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.451 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.451 | |
| 3erd | DES | Estrogen receptor | / | 0.451 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.451 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.451 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.450 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.450 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.450 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.450 | |
| 2pix | DHT | Androgen receptor | / | 0.450 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 3up3 | XCA | aceDAF-12 | / | 0.450 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.450 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4pxm | EST | Estrogen receptor | / | 0.450 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.450 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.449 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.449 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1r2j | FAD | FkbI | / | 0.449 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.449 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.449 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.449 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.449 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.449 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.449 | |
| 4g1q | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.449 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.449 | |
| 1eet | BFU | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.448 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.448 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.448 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1yin | CM3 | Estrogen receptor | / | 0.448 | |
| 1zaf | 789 | Estrogen receptor beta | / | 0.448 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.448 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.448 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.448 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.448 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.448 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.448 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 1fr8 | GDU | Beta-1,4-galactosyltransferase 1 | / | 0.447 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.447 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.447 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.447 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.447 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.447 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.447 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.447 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.447 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.447 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.447 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.447 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.446 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.446 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1syn | F89 | Thymidylate synthase | / | 0.446 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.446 | |
| 2a8s | GTP | U8 snoRNA-decapping enzyme | / | 0.446 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.446 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4zp1 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.446 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 1gwq | ZTW | Estrogen receptor | / | 0.445 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.445 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.445 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1xow | R18 | Androgen receptor | / | 0.445 | |
| 1xpc | AIT | Estrogen receptor | / | 0.445 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.445 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.445 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.445 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.445 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.445 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.445 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 5gcn | COA | HAT A1 | / | 0.445 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1hni | AAA | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.444 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.444 | |
| 1t7r | DHT | Androgen receptor | / | 0.444 | |
| 1u9e | 397 | Estrogen receptor beta | / | 0.444 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 2ayr | L4G | Estrogen receptor | / | 0.444 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.444 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.444 | |
| 2pir | DHT | Androgen receptor | / | 0.444 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.444 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.444 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.444 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.444 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.444 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3ols | EST | Estrogen receptor beta | / | 0.444 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4egn | TWO | Cytochrome P450 | / | 0.444 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.444 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.444 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.444 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.444 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.443 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1hk4 | T44 | Serum albumin | / | 0.443 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.443 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1x7r | GEN | Estrogen receptor | / | 0.443 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 2plm | SIB | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | 3.5.4.28 | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.443 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.443 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.443 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.443 | |
| 3wfg | WFG | Mineralocorticoid receptor | / | 0.443 | |
| 4dma | 0L8 | Estrogen receptor | / | 0.443 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.443 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.443 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4la0 | 198 | Serum albumin | / | 0.443 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.443 | |
| 5dx3 | EST | Estrogen receptor | / | 0.443 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.442 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.442 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.442 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2wuu | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.442 | |
| 2yat | EEU | Estrogen receptor | / | 0.442 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3d57 | 4HY | Thyroid hormone receptor beta | / | 0.442 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.442 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.442 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 4ho5 | DAU | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4iw6 | 1GU | Estrogen receptor | / | 0.442 | |
| 4jnm | 1LJ | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 4kfn | 1QR | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.442 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.442 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.442 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.441 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 2fjn | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.441 | |
| 2nv7 | 555 | Estrogen receptor beta | / | 0.441 | |
| 2r8v | ACO | Amino-acid acetyltransferase | / | 0.441 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2yja | EST | Estrogen receptor | / | 0.441 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 3up0 | D7S | aceDAF-12 | / | 0.441 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.441 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.441 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 4l9k | EHF | Serum albumin | / | 0.441 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.441 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.441 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.440 | |
| 1cx2 | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1jmf | UMP | Thymidylate synthase | / | 0.440 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.440 | |
| 1yy4 | 4NA | Estrogen receptor beta | / | 0.440 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.440 | |
| 2j7y | E3O | Estrogen receptor beta | / | 0.440 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 3ert | OHT | Estrogen receptor | / | 0.440 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.440 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.440 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.440 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.440 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.440 |