sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3uku | C69 | Actin-related protein 3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3uku | C69 | Actin-related protein 3 | / | 1.000 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.677 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.615 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.491 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.489 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.487 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.485 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.478 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.460 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.460 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.459 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.456 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.456 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.455 | |
| 4wx1 | FDA | UDP-galactopyranose mutase | / | 0.455 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.454 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.453 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 4lb2 | DM5 | Serum albumin | / | 0.453 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.452 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.450 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.450 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.449 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.449 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.449 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.448 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.446 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.445 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.443 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.443 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.443 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.442 | |
| 2y65 | ADP | Kinesin heavy chain | / | 0.442 | |
| 4n6b | COA | Uncharacterized protein | / | 0.442 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.441 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.441 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.440 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.440 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.440 |