sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ugc | 046 | Tyrosine-protein kinase JAK2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ugc | 046 | Tyrosine-protein kinase JAK2 | / | 1.000 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.593 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.590 | |
| 2e2b | 406 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.562 | |
| 3nnx | EDD | Mitogen-activated protein kinase 14 | / | 0.561 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.560 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.557 | |
| 3p7b | P7B | Mitogen-activated protein kinase 14 | / | 0.552 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.544 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 1wbt | WBT | Mitogen-activated protein kinase 14 | / | 0.537 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.532 | |
| 3cs9 | NIL | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.530 | |
| 4u0i | 0LI | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.530 | |
| 3gcu | R48 | Mitogen-activated protein kinase 14 | / | 0.529 | |
| 3gvu | STI | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.522 | |
| 3wze | BAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.521 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.519 | |
| 1wbs | LI2 | Mitogen-activated protein kinase 14 | / | 0.517 | |
| 1w82 | L10 | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 3uvr | 06F | Mitogen-activated protein kinase 14 | / | 0.512 | |
| 3p7c | P7C | Mitogen-activated protein kinase 14 | / | 0.508 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.508 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.508 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 3orn | 3OR | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.504 | |
| 3dy7 | 1CX | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.503 | |
| 3p78 | P78 | Mitogen-activated protein kinase 14 | / | 0.503 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 3o8u | BMU | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 2hz0 | GIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.500 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.500 | |
| 2hiw | 7MP | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.498 | |
| 1s9j | BBM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.497 | |
| 3e93 | 19B | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 3vhe | 42Q | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.497 | |
| 3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.496 | |
| 3p7a | P7A | Mitogen-activated protein kinase 14 | / | 0.496 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.494 | |
| 1kv1 | BMU | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 3nnw | EDD | Mitogen-activated protein kinase 14 | / | 0.491 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.489 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.486 | |
| 1wbv | LI3 | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 1wbn | L09 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.485 | |
| 3gcv | SS6 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 2yiw | YIW | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 3npc | B96 | Mitogen-activated protein kinase 9 | 2.7.11.24 | 0.480 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.480 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.479 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.478 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.478 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.477 | |
| 2p55 | MRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.476 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.475 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.474 | |
| 1hvh | Q82 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.473 | |
| 2yis | YIS | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.473 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.472 | |
| 1mer | DMQ | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 3v01 | 3V0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.472 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.471 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.470 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.470 | |
| 4ei7 | GDP | Plasmid replication protein RepX | / | 0.470 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4r7i | STI | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.468 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.467 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.467 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.466 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 3sa9 | A68 | Protease | / | 0.465 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.465 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.465 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.464 | |
| 2q5k | AB1 | Protease | / | 0.464 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.464 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.464 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.463 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.462 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.462 | |
| 2qi5 | MZ7 | Gag-Pol polyprotein | / | 0.462 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.462 | |
| 1c6y | MK1 | Protease | / | 0.461 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.461 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 3qn8 | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3sa3 | 23X | Protease | / | 0.461 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 4beb | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.461 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.461 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2r38 | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.460 | |
| 3hv4 | L51 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4b1v | LAB | Actin, alpha skeletal muscle | / | 0.460 | |
| 4lmn | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.460 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 1n07 | FMN | Riboflavin kinase | 2.7.1.26 | 0.459 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.459 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.458 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.458 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.457 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.457 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.457 | |
| 3kf0 | 3TL | Gag-Pol polyprotein | / | 0.457 | |
| 3nu3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.456 | |
| 1hk4 | T44 | Serum albumin | / | 0.456 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.456 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.456 | |
| 3d83 | GK6 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1c0f | ATP | Major actin | / | 0.455 | |
| 1daz | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2hs2 | 017 | Protease | / | 0.455 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.455 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.455 | |
| 1tqp | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.454 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.454 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4b5b | BBE | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.454 | |
| 4s32 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 1csn | ATP | Casein kinase I homolog 1 | 2.7.11.1 | 0.453 | |
| 1h1q | 2A6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.453 | |
| 1sx4 | ADP | 60 kDa chaperonin | / | 0.453 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.453 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.453 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.453 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.453 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.453 | |
| 4be7 | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.453 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.453 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.453 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.453 | |
| 1hvi | A77 | Protease | / | 0.452 | |
| 1npv | L27 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.452 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2i4v | DJR | V-1 protease | / | 0.452 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2qhc | AB1 | Protease | / | 0.452 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3o9a | K14 | Pol polyprotein | / | 0.452 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3qw2 | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.452 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.452 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.452 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 5ks7 | 2BA | Carnitine transport ATP-binding protein OpuCA | 3.6.3.32 | 0.452 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.451 | |
| 3s54 | 017 | Protease | / | 0.451 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4an2 | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.451 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4k4p | 3TL | Gag-Pol polyprotein | / | 0.451 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2idw | 017 | Protease | / | 0.450 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2v1x | ADP | ATP-dependent DNA helicase Q1 | 3.6.4.12 | 0.450 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.450 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.450 | |
| 4b1u | LAB | Actin, alpha skeletal muscle | / | 0.450 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.450 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.450 | |
| 1hvs | A77 | Gag-Pol polyprotein | / | 0.449 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.449 | |
| 1rkd | ADP | Ribokinase | / | 0.449 | |
| 2biy | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.449 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3qyw | 6PB | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.449 | |
| 1jsc | FAD | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.448 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.448 | |
| 2i4d | QFI | Protease | / | 0.448 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2vrx | 447 | Aurora kinase B-A | 2.7.11.1 | 0.448 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3n4m | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.448 | |
| 3nbw | TR4 | Ketohexokinase | / | 0.448 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.448 | |
| 4gy2 | LAR | Actin, alpha skeletal muscle | / | 0.448 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.448 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1hvr | XK2 | Gag-Pol polyprotein | / | 0.447 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2i4w | KGQ | Protease | / | 0.447 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3lzv | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.447 | |
| 3mvh | WFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.447 | |
| 3nxe | 2NC | Protease | / | 0.447 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.447 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 1b6k | PI5 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1c6z | ROC | Protease | / | 0.446 | |
| 1ijj | ATP | Actin, alpha skeletal muscle | / | 0.446 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.446 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.446 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.446 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3uim | ANP | BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 | 2.7.10.1 | 0.446 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.446 | |
| 4ccb | OFG | ALK tyrosine kinase receptor | 2.7.10.1 | 0.446 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 4xjx | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.446 | |
| 1h5r | THM | Glucose-1-phosphate thymidylyltransferase 1 | / | 0.445 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.445 | |
| 2b5v | NAP | Glucose 1-dehydrogenase | / | 0.445 | |
| 3anx | MTA | Polyamine aminopropyltransferase | / | 0.445 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3fzr | 3JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.445 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.445 | |
| 3t99 | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.445 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.445 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.445 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 4s34 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 5f0a | 1FB | cGMP-dependent protein kinase, putative | / | 0.445 | |
| 9hvp | 0E9 | Gag-Pol polyprotein | / | 0.445 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.445 | |
| 1ec0 | BED | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.444 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 3eky | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.444 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.444 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3s43 | 478 | Protease | / | 0.444 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4dqc | 017 | Gag-Pol polyprotein | / | 0.444 | |
| 4o4e | ATP | Kinase | / | 0.444 | |
| 1hk1 | T44 | Serum albumin | / | 0.443 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.443 | |
| 3lit | E15 | Protease | / | 0.443 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3w55 | 1FM | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.443 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4njt | 017 | Protease | / | 0.443 | |
| 1h9z | RWF | Serum albumin | / | 0.442 | |
| 1met | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1mtr | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2exl | GDM | Endoplasmin | / | 0.442 | |
| 2g2f | AGS | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2p3a | 3TL | Pol protein | / | 0.442 | |
| 2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.442 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.442 | |
| 3qrt | X14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3t54 | ATP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.442 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.442 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.442 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 4l04 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 5c8y | ACP | Tubulin tyrosine ligase | / | 0.442 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.441 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.441 | |
| 2eft | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.441 | |
| 2f3k | RO1 | Protease | / | 0.441 | |
| 2i4x | KGQ | Protease | / | 0.441 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2uy0 | HV1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 2xyf | G40 | Gag-Pol polyprotein | / | 0.441 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3el0 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3k3b | ADP | Kinesin-like protein KIF11 | / | 0.441 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3liv | E16 | Protease | / | 0.441 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3r28 | XA0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4b2w | BZ0 | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.441 | |
| 1a94 | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.440 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.440 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3jx3 | JI5 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 3lq5 | SLQ | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.440 | |
| 3mws | 017 | Pol protein | / | 0.440 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.440 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3r73 | X87 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sa7 | 55A | Protease | / | 0.440 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4awg | CI3 | Polymerase acidic protein | / | 0.440 | |
| 4bi1 | ZO6 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.440 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4g36 | SLU | Luciferin 4-monooxygenase | 1.13.12.7 | 0.440 | |
| 4hvg | 19Q | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
| 4kfp | 1R7 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 4l4x | NDP | AmphI | / | 0.440 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 |