sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3tw6 | ADP | Pyruvate carboxylase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3tw6 | ADP | Pyruvate carboxylase | / | 1.000 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.490 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.483 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.462 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.457 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.452 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.445 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 2y3r | TRK | TamL | / | 0.444 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.443 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5eoy | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.441 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3suf | SUE | Polyprotein | / | 0.440 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.440 |