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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tubFPUTyrosine-protein kinase SYK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tubFPUTyrosine-protein kinase SYK2.7.10.21.000
3ctj320Hepatocyte growth factor receptor2.7.10.10.543
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.541
3eta351Insulin receptor2.7.10.10.540
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.536
3ce31FNHepatocyte growth factor receptor2.7.10.10.517
4eevL1XHepatocyte growth factor receptor2.7.10.10.515
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.510
4qrc0LIFibroblast growth factor receptor 42.7.10.10.510
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.505
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.501
4kaoKAOFocal adhesion kinase 12.7.10.20.501
2og81N8Tyrosine-protein kinase Lck2.7.10.20.497
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.495
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.482
4eyjN61Mitogen-activated protein kinase 132.7.11.240.480
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.479
3hng8STVascular endothelial growth factor receptor 12.7.10.10.475
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.475
2hyySTITyrosine-protein kinase ABL12.7.10.20.473
4fnyI3KALK tyrosine kinase receptor2.7.10.10.472
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4r20AERCytochrome P450 family 17 polypeptide 2/0.465
3qm4PN0Cytochrome P450 2D6/0.458
3iw8HIZMitogen-activated protein kinase 14/0.455
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.454
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.450
2pobGW4Peroxisome proliferator-activated receptor gamma/0.449
3tdaPN0Cytochrome P450 2D6/0.449
3abaFLICytochrome P450/0.444
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.443
3w2cN15Aurora kinase A2.7.11.10.441
4o2z046Mitogen-activated protein kinase/0.441
2xir00JVascular endothelial growth factor receptor 22.7.10.10.440
4ia2BIVVitamin D3 receptor A/0.440
4j6dTESCytochrome P450 monooxygenase/0.440
5jtbZMAAdenosine receptor A2a/0.440