sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.605 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.601 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.575 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.572 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.569 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.568 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.566 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.565 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.563 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.563 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.556 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.552 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.548 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.541 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.532 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.531 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.529 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.522 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.514 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.509 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.508 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.507 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.497 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.495 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.493 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.492 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.489 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.488 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.486 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.483 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.481 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.471 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.469 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.467 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.465 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.462 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.461 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.458 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.454 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.453 | |
| 3f8d | FAD | NADH oxidase/thioredoxin reductase | / | 0.451 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.450 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.449 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.448 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.447 | |
| 3s3r | 0IW | Cathepsin B-like peptidase (C01 family) | / | 0.447 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.446 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.444 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 |