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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tljSAHUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tljSAHUncharacterized protein/1.000
3tm4SAMUncharacterized protein/0.632
3tm5SFGUncharacterized protein/0.607
1booSAHModification methylase PvuII2.1.1.1130.513
3ldgSAHUncharacterized protein/0.491
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.483
1iyzNDPProbable quinone oxidoreductase/0.479
3friSAH16S rRNA methylase/0.476
1rf9DBRCamphor 5-monooxygenase1.14.15.10.471
4ea2RWZDehydrosqualene synthase/0.469
3swrSFGDNA (cytosine-5)-methyltransferase 12.1.1.370.468
3grySAMProbable ribosomal RNA small subunit methyltransferase A/0.467
3acw651Dehydrosqualene synthase/0.465
1nw5SAMModification methylase RsrI2.1.1.720.463
3l0lHC3Nuclear receptor ROR-gamma/0.463
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.462
3g7jGTXGlutathione transferase GST1-4/0.461
3c3ySAHO-methyltransferase/0.459
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.459
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.457
2dpmSAMModification methylase DpnIIA2.1.1.720.456
3pdqKC6Lysine-specific demethylase 4A1.14.110.456
4rv9SAHD-mycarose 3-C-methyltransferase/0.455
1kkq471Peroxisome proliferator-activated receptor alpha/0.454
4fr0SAMArsenic methyltransferase/0.454
4g95OAGDihydrofolate reductase1.5.1.30.454
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2g1pSAHDNA adenine methylase2.1.1.720.452
2wa2SAMGenome polyprotein/0.452
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.452
4necSAHPutative SAM-dependent methyltransferase/0.452
4rtlSFGDNA adenine methylase2.1.1.720.452
4rtmSAMDNA adenine methylase2.1.1.720.451
1nvtNAPShikimate dehydrogenase (NADP(+))/0.450
2z6uSAHModification methylase HhaI2.1.1.370.450
5bp9SAHPutative methyltransferase protein/0.450
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.449
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.449
3reyXACAdenosine receptor A2a/0.448
2hmySAMModification methylase HhaI2.1.1.370.447
3f63GTXGlutathione transferase GST1-4/0.447
3ldfSAHUncharacterized protein/0.447
3p9tTCLRepressor/0.445
3tdaPN0Cytochrome P450 2D6/0.444
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2bzgSAHThiopurine S-methyltransferase2.1.1.670.442
2j8zNAPQuinone oxidoreductase PIG310.442
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.442
2i9kSAHModification methylase HhaI2.1.1.370.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
5mhtSAHModification methylase HhaI2.1.1.370.441
1c6yMK1Protease/0.440
2zcjSAHModification methylase HhaI2.1.1.370.440
3ekp478Gag-Pol polyprotein3.4.23.160.440