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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tl1JROPutative polyketide cyclase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tl1JROPutative polyketide cyclase/1.000
3ebf332Nitric oxide synthase, inducible1.14.13.390.464
2y6fM9FIsopenicillin N synthase1.21.3.10.455
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
3png8CXNitric oxide synthase, brain1.14.13.390.452
1hb3SCVIsopenicillin N synthase1.21.3.10.447
1kzjCB3Thymidylate synthase/0.446
1bk0ACVIsopenicillin N synthase1.21.3.10.445
1fm4DXCMajor pollen allergen Bet v 1-L/0.444
2vbpVB1Isopenicillin N synthase1.21.3.10.443
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.443
1qjfACSIsopenicillin N synthase1.21.3.10.442
1qiqACCIsopenicillin N synthase1.21.3.10.441
2vbdV10Isopenicillin N synthase1.21.3.10.441
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.441