scPDB - Distribution of Binding site Similarity values of 3td8 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3td8	D2R	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3td8	D2R	Dihydrofolate reductase	1.5.1.3	1.000
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.689
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.665
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.626
3eel	53T	Uncharacterized protein	/	0.603
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.589
3cse	N22	Uncharacterized protein	/	0.582
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.576
3eek	53S	Uncharacterized protein	/	0.576
3qlz	QLZ	Uncharacterized protein	/	0.571
3qlx	QLR	Uncharacterized protein	/	0.567
3eej	53R	Uncharacterized protein	/	0.565
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.563
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.560
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.553
3qly	55V	Uncharacterized protein	/	0.553
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.551
3eem	53V	Uncharacterized protein	/	0.547
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.547
4h98	14Q	Uncharacterized protein	/	0.546
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.545
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.544
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.542
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.542
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.541
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.531
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.529
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.526
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.521
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.520
2w3v	TOP	Dihydrofolate reductase	/	0.519
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.519
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.516
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.515
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.513
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.512
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.511
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.506
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.506
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.506
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.504
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.503
3ia4	MTX	Dihydrofolate reductase	/	0.502
3sa1	6DR	Dihydrofolate reductase	/	0.497
2zza	FOL	Dihydrofolate reductase	/	0.495
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.494
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.493
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.490
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.490
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.490
3jw5	TOP	Dihydrofolate reductase	/	0.489
3jwc	EKB	Dihydrofolate reductase	/	0.487
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.484
3sa2	7DR	Dihydrofolate reductase	/	0.484
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.484
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.481
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.480
3jwm	5WB	Dihydrofolate reductase	/	0.480
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.478
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.478
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.476
4ele	31I	Dihydrofolate reductase	/	0.476
4elg	52J	Dihydrofolate reductase	/	0.475
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.474
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.472
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.472
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.472
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.471
3aba	FLI	Cytochrome P450	/	0.470
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.470
4p66	MTX	Dihydrofolate reductase	/	0.470
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.469
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.469
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.469
3a1l	2CC	Cytochrome P450	/	0.467
3sai	9DR	Dihydrofolate reductase	/	0.467
2z3u	CRR	Cytochrome P450	/	0.465
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.464
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.463
3tq9	MTX	Dihydrofolate reductase	/	0.463
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.463
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.462
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.461
3tqb	FOL	Dihydrofolate reductase	/	0.461
4ia2	BIV	Vitamin D3 receptor A	/	0.460
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.459
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.459
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.457
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.456
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.455
4elb	34S	Dihydrofolate reductase	/	0.455
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.454
4j6d	TES	Cytochrome P450 monooxygenase	/	0.453
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.451
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.451
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.450
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.450
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.450
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.448
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.448
1kzj	CB3	Thymidylate synthase	/	0.447
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.447
4ia1	BIV	Vitamin D3 receptor A	/	0.445
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.445
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.444
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.444
1zg3	2HI	Isoflavone 4'-O-methyltransferase	/	0.443
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.443
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3srr	Q20	Dihydrofolate reductase	1.5.1.3	0.442
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.441
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.441
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.441
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.441
4nky	3QZ	Steroid 17-alpha-hydroxylase/17,20 lyase	/	0.441
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.440
3dat	MTX	Dihydrofolate reductase	/	0.440
4l9q	9TP	Serum albumin	/	0.440